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20 January 2023, Volume 21 Issue 1 Previous Issue    Next Issue

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Expert Editorial

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Reconstruction of large head and neck defects with extended vertical lower trapezius island myocutaneous flap CHEN Wei-liang 2023, 21 (1):  1-10.  doi: 10.19438/j.cjoms.2023.01.001 Abstract ( 189 )   PDF (3397KB) ( 109 )   The extended vertical lower trapezius island myocutaneous flap (eVLTIMF) supplied by the transverse cervical artery is safe and reliable for reconstruction of large head and neck defects. The flap is easy to harvest, and the survival rate is high. The donor area is hidden, which can be closed and sutured directly, with fewer complications and less impact on shoulder movement. It can also be made into folded flaps, combined with other pedicled flaps or combined scapular osteomyocutaneous flap was used to repair huge through-and-through defect or defects of the mandible. It is believed that eVLTIMF can play an important role in the repair of large head and neck defects, especially in the repair and reconstruction of huge defects flowing salvage surgery for advanced recurrent head and neck tumors. The clinical applied anatomy of the trapezius muscle, harvesting eVLTIMF flap and application in the reconstruction of craniomaxillofacial, oral maxillofacial and maxillocervical defects were described in this paper. References | Related Articles | Metrics

Original Articles

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Synthesis of carbon dots with dual roles of osteogenic and antibacterial effects for infected bone defects treatment LIU Yi-ge, WANG Zi-lin, GUO Zhi-yong, WU Hao, WANG Wen-ying, HAN Jing, LIU Jian-nan, ZHANG Chen-ping 2023, 21 (1):  11-18.  doi: 10.19438/j.cjoms.2023.01.002 Abstract ( 199 )   PDF (2337KB) ( 169 )   PURPOSE: To investigate the effects of a new kind of carbon dots (CDots) made from gentamicin and folic acid on osteogenic differentiation and autophagy of rat bone marrow stromal cells (BMSCs), as well as the inhibition of common oral pathogenic bacteria. METHODS: CDots were prepared by hydrothermal method using gentamicin and folic acid as raw materials, and characterized by transmission electron microscopy and UV spectrophotometer. Biocompatibility was evaluated by CCK-8 assay and apoptosis assay, and uptake by cells was observed by laser confocal microscopy. Alkaline phosphatase staining and alizarin red staining were used to detect the effect on osteogenic differentiation of BMSCs. Real-time quantitative PCR was performed to detect the mRNA expression levels of osteogenic and autophagy-related genes. Scanning electron microscopy and plate colony assay were performed to observe the ability of CDots to inhibit Porphyromonas gingivalis and Fusobacterium nucleatum. Graph Pad Prism 9 software was used for statistical analysis. RESULTS: The CDots solution emitted blue fluorescence under UV light irradiation with a UV absorption peak at 330 nm; the PL emission peak of CDots was concentrated at 440 nm under the excitation of 405 nm laser. Transmission electron microscopy showed that the average diameter of CDots was about 12 nm. CCK-8 assay and apoptosis assay showed that CDots were biocompatible. Laser confocal microscopy results showed that CDots could be taken up by BMSCs. The results of alkaline phosphatase staining and alizarin red staining showed that CDots increased staining. mRNA expression of the osteogenic genes OPN, OCN, BMP-2, and autophagy-related genes LC3, Beclin1, ATG-12 was increased by CDots compared to the control group(P<0.05). In vitro antibacterial assays indicated that CDots could inhibit the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. CONCLUSIONS: CDots prepared with gentamicin and folic acid are biocompatible, have dual osteogenic and antibacterial effects, promote osteogenic differentiation of BMSCs, promote elevated autophagy levels, and have inhibitory effects on the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. References | Related Articles | Metrics

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Expression and significance of sclerostin in the process of alveolar bone reconstruction in type 2 diabetic rats with periodontitis LIU Xiao-dong, ZHANG Ying, MA Jin-yu, LI Yu-zeng 2023, 21 (1):  19-23.  doi: 10.19438/j.cjoms.2023.01.003 Abstract ( 152 )   PDF (1216KB) ( 57 )   PURPOSE: To observe the expression of sclerostin in the process of alveolar bone reconstruction in rats with type 2 diabetes (T2DM) and periodontitis. METHODS: Fifty-four SD rats were randomly divided into control group, periodontitis group, and T2DM with periodontitis group with 18 rats in each group. The periodontitis group included a rat model with periodontitis, and the T2DM with periodontitis group included a T2DM model first, and then established a periodontitis model. The glucose metabolism indicators were detected at 1, 5, and 10 days after intraperitoneal injection of STZ. The periodontal indexes were detected at 8 weeks after ligation. The expression of sclerostin in alveolar bone tissue were detected by immunohistochemical staining 1, 3, 6 months after successful modeling. SPSS 21.0 software package was used for data analysis. RESULTS: Compared with unmodeled rats, fasting blood glucose (FBG) at 1, 5, and 10 days after intraperitoneal injection of STZ, fasting serum insulin(FINS) and homeostasis model assessment for insulin resistance (HOMA-IR) at 10 days after intraperitoneal injection of STZ in T2DM model rats were increased (P<0.05). Compared with unmodeled rats, the gingival bleeding index(SBI), plaque index (PLI) and probe depth (PD) in periodontitis model rats were increased(P<0.05). Compared with control group, the expression of sclerostin in the alveolar bone tissue at 1, 3, and 6 months after successful modeling in periodontitis group and T2DM with periodontitis group was increased(P<0.05), which was significantly higher in T2DM with periodontitis group than in periodontitis group (P<0.05). Compared with 1 month after successful modeling, the expression of sclerostin in the alveolar bone tissue at 3, 6 months after successful modeling in periodontitis group and T2DM with periodontitis group was increased(P<0.05). Compared with 3 months after successful modeling, the expression of sclerostin in the alveolar bone tissue at 6 months after successful modeling in periodontitis group and T2DM with periodontitis group was decreased(P<0.05). CONCLUSIONS: The expression of sclerostin is increased in periodontitis, and the expression of sclerostin with T2DM is further up-regulated, but it is gradually down-regulated during the process of bone remodeling. References | Related Articles | Metrics

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Evaluation of the application of conformal radial forearm flap in repair of irregular facial soft tissue defects GE Liang-yu, JI Li, WANG Hao-ran, LI Zhi-ping, GU Qian-ping, MENG Jian 2023, 21 (1):  24-28.  doi: 10.19438/j.cjoms.2023.01.004 Abstract ( 170 )   PDF (1137KB) ( 84 )   PURPOSE: To evaluate the effect of free transplantation of conformal radial forearm flap in the repair of irregular skin and soft tissue defects in the cheek. METHODS: Nine patients with irregular skin and soft tissue defects caused by facial trauma or tumor treated in Xuzhou Central Hospital from January 2020 to December 2021 were selected. Personalized matching free forearm flap were designed, the short-term effect of skin flap repair and patient satisfaction were observed. Self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to evaluate the psychological state of patients before and after surgery. SPSS 20.0 software package was used for data analysis. RESULTS: All the flaps survived smoothly after operation. The SDS score and SAS score of patients 2 weeks after operation were lower than those before operation, and the difference was statistically significant(P<0.05). There was no significant difference in thickness and color between the flap and the surrounding skin, no traction and asymmetry, and the effect of appearance and functional repair was satisfactory. The satisfaction rate was 88.89%. CONCLUSIONS: The free radial forearm flap with conformal shape has a good effect in repairing irregular soft tissue defects in the cheek. The scores of anxiety and depression improved significantly in the short term after operation, and the patients have high postoperative satisfaction; therefore, it is worthy of clinical application. References | Related Articles | Metrics

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Comparative study on accuracy of 2 kinds of CAD/CAM dental digital guide plates in dental implantation DAI Xiao-feng, HUANG Xin, LI Cheng, WANG Chen-xin, SHI Le, YU You-cheng 2023, 21 (1):  29-35.  doi: 10.19438/j.cjoms.2023.01.005 Abstract ( 293 )   PDF (1955KB) ( 77 )   PURPOSE: To compare the accuracy of 2 kinds of CAD/CAM dental digital guides in dental implantation. METHODS: A total of 36 patients with oral implants from Dental Disease Prevention and Control Institute of Shanghai Jing’an District were selected for CBCT examination and intraoral laser scanning. The data obtained were imported into 3Shape software and designed before operation. Two guides were generated in each case. Data of A guide plate came from the fitting of CBCT, while data of B guide plate for CBCT and intraoral laser scanning, and the type of guide plate was randomly selected and used. After operation, CBCT was taken and the data were imported into the design software, and the position of the design before implantation was compared. R software (version 4.1.0) was used for data analysis. RESULTS: The distance deviation of the top center point of the implant, the distance deviation of the center point at the bottom of the implant and the angle deviation of the line connecting the two center points in B guide plate group were significantly lower than those in A guide plate (P<0.05). CONCLUSIONS: The accuracy of CAD/CAM dental digital guide plate generated by the fitting of CBCT and intraoral laser scanning data is higher, which is helpful to improve the accuracy of three-dimensional position of dental implant. References | Related Articles | Metrics

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Imaging evaluation and analysis of jaw invasion in mandibular gingival carcinoma based on micro-CT WANG Jian, ZHANG Ye, HOU Cheng-su 2023, 21 (1):  36-40.  doi: 10.19438/j.cjoms.2023.01.006 Abstract ( 246 )   PDF (937KB) ( 158 )   PURPOSE: To evaluate and analyze the imaging features of mandibular invasion, in order to provide imaging evidences for optimizing the operation plan and guiding postoperative treatment for gingival squamous cell carcinoma (GSCC). METHODS: Sixty patients underwent surgery for mandibular GSCC were included. Preoperative panoramic radiograph, ordinary CT and enhanced CT scanning were analyzed. Micro-CT three-dimensional reconstruction was performed on 30 eligible surgical specimens in order to measure bone mineral density, trabecular thickness, trabecular separation and other related parameters. SPSS 22.0 software package was used for data analysis. RESULTS: Conventional imaging examination with panoramic radiograph, CT and enhanced CT scaning were insufficient. Micro-CT three-dimensional reconstruction could accurately distinguish between cancellous bone and bone cortex, assess the scope and degree of mandibular invasion. The corresponding data parameter analysis indicated that bone mineral density (BMD) of the GSCC central and marginal area was significantly reduced comparing with the BMD at the normal mandibular bone area(P<0.05). In addition, the thickness of trabecular bone was also significantly reduced（P<0.05). The BMD of cancellous bone was significantly decreased(P<0.05). The separation degree of trabecular bone in cancer center was obviously increased comparing with the normal mandibular tissue(P<0.05). CONCLUSIONS: Currently, there are still controversies about the surgical plan for mandibular gingival cancer, and further improving the accuracy of CT examination may provide more accurate guidance for making surgical plan for mandibular gingival cancer. References | Related Articles | Metrics

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Relationship between cervical lymph node characteristics and prognosis in oral squamous cell carcinoma SU Zi-shang, CUI Wen-li, ZHANG Meng-yun, YAO Zhi-tao 2023, 21 (1):  41-48.  doi: 10.19438/j.cjoms.2023.01.007 Abstract ( 149 )   PDF (1382KB) ( 67 )   PURPOSE: To investigate the clinical and pathological features of cervical negative lymph nodes in oral squamous cell carcinoma (OSCC), and to study its relationship with neck recurrence and overall survival in OSCC patients. METHODS: A total of 100 OSCC patients who were treated in the First Affiliated Hospital of Xinjiang Medical University from January 2017 to January 2021 were retrospectively analyzed. The end points of the study were neck recurrence and death.Survival curve was analyzed by Kaplan-Meier and Cox proportional hazards regression analysis was used to investigate the factors of prognosis in OSCC. SPSS 21.0 software package was used for data analysis. RESULTS: The average follow-up time of 100 patients was 30 months, and 10 patients were lost to follow-up. Among the 90 patients,11 cases (12%) had recurrence of cervical lymph node metastasis, 28 cases(31.1%) died, 27 cases (30%) had sinus histiocytosis(SH) in negative lymph nodes, the 3-year recurrence-free rate was 89.4%, and the 3-year overall survival rate was 67.3%. Cox proportional hazards regression analysis of 90 patients showed that degree of tumor differentiation, N stage and clinical stage had significant influence on OS (P<0.05). Smoking, cervical lymph node metastasis in the first operation (N≠0), SH and bilateral neck dissection had significant influence on neck recurrence (P<0.05), and patients who smoked, with cervical lymph node metastasis in the first operation, accompanied by SH and underwent bilateral neck dissection had higher probability of neck recurrence. CONCLUSIONS: SH and primary cervical lymph node metastasis are independent risk factors for the recurrence and metastasis of cervical lymph node in OSCC patients. N stage is survival prognostic factor. References | Related Articles | Metrics

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Efficacy of decompression for large odontogenic maxillary sinus cysts HU Ying-kai, XU Guang-zhou, MA Zhi-gui, XIE Qian-yang, ZHANG Yong-ya, YANG Chi 2023, 21 (1):  49-54.  doi: 10.19438/j.cjoms.2023.01.008 Abstract ( 159 )   PDF (1221KB) ( 89 )   PURPOSE: To evaluate the effect of decompression for large odontogenic maxillary cysts, and to provide reference for clinical treatment. METHODS: The cases of large odontogenic maxillary cysts in the Department of Oral Surgery, Shanghai Jiao Tong University School of Medicine from January 2011 to December 2020 were reviewed. The patients were treated with decompression and secondary curettage. The patients were divided into non-negative pressure drainage group and negative pressure drainage group according to the type of cyst plug used. Mimics was used to quantitatively measure the change of cyst volume. New bone remodeling and maxillary sinus inflammation were evaluated. The volume change of the cysts was compared by paired t test. The therapeutic effects of different cyst plugs were compared by group t test and chi-square test with SPSS 17.0 software package. RESULTS: A total of 20 patients were included in the study. Ten patients were treated with non-negative pressure drainage and 10 with negative pressure drainage respectively. The volume of the lesions before decompression was (25 993.81±13 611.78) mm3,and significantly reduced to (5 386.30±3 546.30) mm3 after surgery(P<0.001), with a reduction rate of (77.54±13.01)%. The reduction rate of 11 patients was more than 80%, 9 patients between 50% and 80%. The volume reduction rate of non-negative pressure suction group was (72.75±14.16)%, with a superiority rate of 40%. The volume reduction rate of the negative pressure suction group was (82.33±10.29)%, and the superiority rate was 70%, but there was no significant difference between the two groups. Two cases of keratocyst recurred after secondary curettage, and 16 patients had new bone formation in sinus wall after decompression. CONCLUSIONS: Decompression is effective for large maxillary sinus odontogenic cystic lesions, and it can protect important anatomical tissues, which is recommended to be the first treatment for such diseases. References | Related Articles | Metrics

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A retrospective study on the long-term bone resorption of a single free-end dental implant SONG Hao-tian, HONG Duo, QU Xiao-hui 2023, 21 (1):  55-58.  doi: 10.19438/j.cjoms.2023.01.009 Abstract ( 141 )   PDF (571KB) ( 82 )   PURPOSE: To investigate whether there is a difference in bone resorption between free-end and non-free-end single implant. METHODS: A total of 50 patients with tooth loss (50 implants) for implant restoration were selected. According to the tooth position, they were divided into non-free-end missing group (group A) and free-end missing group (group B). One-stage surgery was performed with eligible implants which were of different lengths and 4.1 mm in diameter. Single crown was placed after 3 months, Bone resorption was measured on CBCT after 36 months of follow-up. SPSS 22.0 software package was used for data analysis. RESULTS: There was no loosing or falling off of implants during the follow-up period. The distal bone resorption of group A was (0.288±0.183)mm, and the mesial bone resorption of group A was (0.291±0.136)mm, the distal bone resorption of group B was (0.562±0.201)mm, the mesial bone resorption of group B was (0.425±0.221)mm, the average bone resorption of group A was (0.289±0.144)mm, the average bone resorption of group B was (0.494±0.182)mm. Among them, the distal bone resorption of group B was significantly more than that of group A (P<0.05), and the average bone resorption of group B was significantly more than that of group A(P<0.05). CONCLUSIONS: The amount of bone resorption in the free end of a single implant is significantly higher than that of the non-free-end single implant, suggesting that the free-end single implant restoration has a higher risk of bone resorption. References | Related Articles | Metrics

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Analysis of correlation between the shape of mandibular condylar head and occurrence of sagittal fracture of the condyle WANG Tao-xian, CHENG Li-jun, WEI Ze-quan, PAN Xiang-feng, ZHAO Min-chao 2023, 21 (1):  59-63.  doi: 10.19438/j.cjoms.2023.01.010 Abstract ( 139 )   PDF (850KB) ( 72 )   PURPOSE: To analyze the correlation between the shape of the condyle and the occurrence of unilateral sagittal fracture of the mandibular condyle (SFMC). METHODS: A total of 155 patients with unilateral SFMC treated in the Third Hospital of Hebei Medical University from December 2010 to December 2021 were selected. The spiral CT data of the patients were anlysed using RadiAnt DICOM Viewer software in DICOM format. According to the Yale's classification criteria, the condylar head shape was categorized into 4 types as flat, convex, angle and round. According to Hlawitschka's classification, the sagittal condyle fractures was divided into 3 types as A, B and M. The relationship between condylar morphology and the incidence of unilateral sagittal condylar fractures was analyzed. SPSS 26.0 software package was used for statistical analysis. RESULTS: Among the 155 patients, the proportion of condyle shape on the contralateral side was flat (41.9%), convex (37.4%), round(11.6%) and angle(9.0%). The proportion of condyle sagittal fracture classification was type A (20.6%), type B(42.6%) and type M (36.8%). There was correlation between condylar morphology and the incidence of sagittal condylar fracture(P=0.015). The flat-shaped condyle was more prone to SFMC than the other three types of condyle. Angular condyle was less prone to SFMC than the other three types of condyle. CONCLUSIONS: The different condyle shape will affect the occurrence of sagittal condyle fracture, flat condyle was more prone to sagittal fracture, while the angular condyle was less prone to sagittal fractures. References | Related Articles | Metrics

Clinical Reports

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Clinical analysis of emergency treatment of 326 patients with oral craniomaxillofacial trauma under triage system GE Wei-wen, WU Jia-jun, GE Kui, FAN Jing-xian, XU Hui, XU Bing, ZHANG Yong, ZHANG Shi-lei, ZHANG Lei 2023, 21 (1):  64-68.  doi: 10.19438/j.cjoms.2023.01.011 Abstract ( 151 )   PDF (618KB) ( 53 )   PURPOSE: To summarize the experience of emergency treatment of oral craniomaxillofacial trauma under triage system. METHODS: The emergency treatment of patients with craniomaxillofacial trauma in the Southern District of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from September 2020 to August 2021 was retrospectively analyzed. A total of 36 599 patients were treated during the period, 1 683 cases were treated by emergency observation and 326 were hospitalized. Pre-admission treatment of inpatients, including basic life support (emergency hemostasis, fluid resuscitation, injury control surgery), injury situations, advanced life support, multidisciplinary treatment and outcomes, were collected. SPSS 13.0 software package was used for statistical analysis. RESULTS: Among 326 emergency patients, 253 were male and 73 were female, with a ratio of 3.47 to 1. Their age ranged from 20 to 73 years, with an average of 41.64±15.34 years. The most common cause was road traffic injury (169 cases), including 138 cases due to electric vehicle accident (81.63%). Life accident injury was followed by 89 cases, including 65 cases of fall injury, accounting for 73.01%. Thirty-three cases had work-related injury, including 14 of fall injury, accounting for 42.42%. Other caused of injuries were noted in 35 cases. Eighty-three patients received primary life support (ECG monitoring, fluid resuscitation, debridement and hemostasis), including 30 patients with blood transfusion, 7 patients with endotracheal intubation or incision, and 9 patients with plaster or braces fixation. Damage control surgery was performed in 65 patients. A total of 235 patients were admitted directly to the Department of Oral and Craniomaxillofacial Surgery, 54 patients were admitted to the corresponding specialty based on trauma, and 37 patients were admitted to EICU to continue advanced life support. All patients were successfully treated, 326 patients were treated by emergency or delayed surgery, and 4 patients were discharged from hospital for secondary repair. CONCLUSIONS: Specialized diagnosis and treatment with first aid is an effective measure to solve the increasing demand for treatment of oral and maxillofacial trauma under triage system. The key to successful treatment of multiple maxillofacial injuries is to take life saving, organ function protection and reconstruction, and social regression as the center to carry out cooperation among various specialties, led by the emergency department. References | Related Articles | Metrics

Evidence-Based Medicine

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Identification of HPV status in head and neck squamous cell carcinoma patients based on radiomics: diagnostic meta-analysis LI Xue-er, WANG Zheng-ye, TUERDI Maimaitituxun 2023, 21 (1):  69-74.  doi: 10.19438/j.cjoms.2023.01.012 Abstract ( 159 )   PDF (930KB) ( 72 )   PURPOSE: To evaluate the value of human papillomavirus (HPV) status in patients with head and neck squamous cell carcinoma (HNSCC) using diagnostic meta-analysis based on radiomics. METHODS: PubMed, Embase, Web of Science, CNKI and VIP databases were searched for literatures related to radiomics identification of HPV status. The retrieval time was from the establishment of the database to May 28, 2022. Statistical software such as Revman 5.4 was used to evaluate the diagnostic performance of the prediction model. RESULTS: A total of 9 papers, including 3312 patients, were included in this study. The combined results showed that the sensitivity, specificity and positive likelihood ratio of radiomic-based methods in the diagnosis of HPV status were 0.82[95%CI(0.74,0.87)], 0.66[95%CI(0.54,0.75)] and 2.4[95%CI(1.8,3.1)], respectively. The negative likelihood ratio was 0.28[95%CI(0.21,0.36)], the diagnostic odds ratio was 9[95%CI(6,12)], and the area under the receiver operating characteristic curve (AUC) was 0.82[95%CI(0.78,0.85)]. HPV status was identified by imaging histochemistry with a 25% pretest probability, which was elevated to 44%(post-test probability). CONCLUSIONS: The radiomics method has high practical value in identification of HPV status in patients with HNSCC. References | Related Articles | Metrics

Review Articles

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Research advances in maxillary sinusitis after Le FortⅠ osteotomy of the maxilla WANG Shou-peng, MENG Jian, ZHANG Lei 2023, 21 (1):  75-80.  doi: 10.19438/j.cjoms.2023.01.013 Abstract ( 182 )   PDF (758KB) ( 106 )   Maxillary sinusitis is a common complication after Le FortⅠ osteotomy, which is highly unfavorable for bone healing. Further clarifying the related factors of maxillary sinusitis after Le FortⅠ osteotomy, taking targeted preventive measures, detecting and treating early are of great significance for reducing the incidence of maxillary sinusitis, accelerating the patient's recovery, and improving the postoperative quality of life. This article summarized the influence, etiology, diagnosis, treatment, and prevention of maxillary sinusitis after Le FortⅠ osteotomy, in order to provide reference for orthognathic surgeons to diagnose and treat maxillary sinusitis early. References | Related Articles | Metrics

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Research progress of the effect of osteoporosis on dental implant restoration JIN Xia-yue, GU Yin-xin 2023, 21 (1):  81-86.  doi: 10.19438/j.cjoms.2023.01.014 Abstract ( 190 )   PDF (700KB) ( 201 )   Osteoporosis is a systemic bone metabolism disease that occurs in middle-aged and elderly people. The incidence of osteoporosis is increasing year by year with the increase of the elderly population. Meanwhile, with the progress of dental implant technology, more and more elderly people undergo implant restoration. Osteoporosis was once considered to be one of the risk factors for dental implant restoration, which may influence the initial stability and survival rate of implants, and drugs for osteoporosis treatment also inevitably affect the osseointegration of implants. This article reviewed relevant studies to summarize the impact of osteoporosis on dental implant restoration. References | Related Articles | Metrics

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Research progress of ferritinophagy and related genes FTH1 and NCOA4 in oral squamous cell carcinoma LIU Heng, DUAN Xiao-feng 2023, 21 (1):  87-91.  doi: 10.19438/j.cjoms.2023.01.015 Abstract ( 267 )   PDF (508KB) ( 137 )   Ferritinophagy is a type of autophagy closely related to ferroptosis. The special cargo receptor NCOA4 mediates the degradation of ferritin in autophagolysosomal lysosomes, and then makes the iron drop bound by ferritin explain the release of free iron, which is an important means of iron metabolism. In recent years, more and more studies have shown that ferritinophagy and ferroptosis play an important role in the occurrence and development of tumors. However, the mechanism of iron autophagy in oral squamous cell carcinoma has not been fully elucidated at present. The in-depth study of the mechanism of ferritinophagy in oral squamous cell carcinoma is expected to become a new target for the treatment of such diseases. This paper summarized the latest progress in the study of the role of ferritinophagy in oral squamous cell carcinoma. References | Related Articles | Metrics

Case Reports

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A case of implant restoration of a patient with maxillary anterior cyst after iliac bone grafting: 5-year outcome review LI Xiao-ni, GUAN Qun-li, LIN Xi-jiang, WANG Yao-zhong 2023, 21 (1):  92-96.  doi: 10.19438/j.cjoms.2023.01.016 Abstract ( 258 )   PDF (2298KB) ( 71 )   In this paper, a case of jaw cyst in the maxillary anterior teeth area was reported. After the maxillary cyst was enucleated, a large number of bone defects in the anterior area was left. Bone augmentation using iliac autologous bone mass was performed, and an implant was inserted 8 months later. The final repair effect was satisfactory. References | Related Articles | Metrics

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A case report of AL amyloidosis complicated with multiple myeloma with dysphagia as the first symptom CHEN Lin, CHEN Yin-yu, DING Zi-xue, MENG Jian 2023, 21 (1):  97-101.  doi: 10.19438/j.cjoms.2023.01.017 Abstract ( 159 )   PDF (1025KB) ( 84 )   Systemic light-chain-type amyloidosis combined with multiple myeloma(MM) is a clinically rare plasma cell-associated malignant disease. Most of the patients with this disease are complained for heart/renal impairment or substantial myeloma, and very few cases presented dysphagia or other oral related diseases as the first symptom, so it is easy to miss diagnosis or make misdiagnosis during first visit. Therefore, the diagnosis and treatment of amyloidosis with dysphagia was reported in the article. Based on the relevant literature review, the characteristics, diagnostic criteria and treatment of the disease were discussed. References | Related Articles | Metrics

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Buccal Rosai-Dorfman disease: a case report and literature review GUANG Meng-kai, YUAN Xu-guang, ZHAO Rui-song, ZHU Jun-fei, ZHU Wen-xuan, JIN Jie-qi, ZHANG Ye 2023, 21 (1):  102-104.  doi: 10.19438/j.cjoms.2023.01.018 Abstract ( 145 )   PDF (829KB) ( 85 )   Rosai-Dorfman disease(RDD) is an unknown etiological and self-limited lymphadenopathy. The case reports are rare, and it is even rarer to occur in the maxillofacial region. This paper reported a case of Rosai-Dorfman disease in the cheek, the etiology, clinical manifestations, diagnosis, treatment and prognosis of Rosai-Dorfman disease were discussed. References | Related Articles | Metrics