Research progress of ferritinophagy and related genes FTH1 and NCOA4 in oral squamous cell carcinoma

doi:10.19438/j.cjoms.2023.01.015

Abstract

Abstract: Ferritinophagy is a type of autophagy closely related to ferroptosis. The special cargo receptor NCOA4 mediates the degradation of ferritin in autophagolysosomal lysosomes, and then makes the iron drop bound by ferritin explain the release of free iron, which is an important means of iron metabolism. In recent years, more and more studies have shown that ferritinophagy and ferroptosis play an important role in the occurrence and development of tumors. However, the mechanism of iron autophagy in oral squamous cell carcinoma has not been fully elucidated at present. The in-depth study of the mechanism of ferritinophagy in oral squamous cell carcinoma is expected to become a new target for the treatment of such diseases. This paper summarized the latest progress in the study of the role of ferritinophagy in oral squamous cell carcinoma.

Key words: NCOA4, FTH1, Ferritinophagy, Ferroptosis, Oral squamous cell carcinoma

CLC Number:

R739.8

LIU Heng, DUAN Xiao-feng. Research progress of ferritinophagy and related genes FTH1 and NCOA4 in oral squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(1): 87-91.

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