Effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma after induction chemotherapy

doi:10.19438/j.cjoms.2022.05.007

Abstract

Abstract: PURPOSE: To observe the effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma (OSCC) after induction chemotherapy. METHODS: A total of 94 patients with OSCC who received docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for the first time were selected and randomly divided into the experimental group and the control group, with 47 cases in each group. Patients in the experimental group were given transcutaneous electrical acupoint stimulation intervention on the basis of conventional treatment, while patients in the control group were given placebo/sham stimulation on the basis of conventional treatment, and were intervened for two cycles of chemotherapy. The counts of white blood cells, hemoglobin, platelets and neutrophils, the grades of myelosuppression, the use of anti-myelosuppressive drugs and the scores of fatigue status were compared between the two groups of patients during the two chemotherapy cycles. SPSS 25.0 software package was used for data analysis. RESULTS: In the second chemotherapy cycle, the hemoglobin, platelet and neutrophil counts on the 6th day of chemotherapy and the platelet count on the 13th day of chemotherapy in the experimental group were significantly higher than those in the control group(P<0.05). In the second chemotherapy cycle, the difference of myelosuppression grades between the two groups was statistically significant(P<0.05), the severity of patients in the experimental group was significantly lower than that in the control group. There was no significant difference in the use of anti-myelosuppressive drugs between the two groups of patients during the two chemotherapy cycles(P>0.05). The total score of fatigue in the experimental group was significantly lower than that in the control group on the 13th day of the first chemotherapy cycle, one day before the second chemotherapy cycle, on the 6th and 13th day of chemotherapy, and the differences were statistically significant(P<0.05). CONCLUSIONS: Transcutaneous electrical acupoint stimulation can help to stabilize the blood index count level of OSCC patients after chemotherapy, reduce the severity of myelosuppression, and relieve their fatigue symptoms.

Key words: Oral squamous cell carcinoma, Induction chemotherapy, Acupoint therapy, Electrical stimulation therapy, Myelosuppression, Fatigue

CLC Number:

R739.8

JI Ping-ping, LI Li, WU Yi-fan, HOU Li-li. Effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma after induction chemotherapy[J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(5): 455-460.

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