Expression and clinical significance of aquaporin 3 in oral mucosal epithelial dysplasia and oral squamous cell carcinoma

doi:10.19438/j.cjoms.2022.05.011

Abstract

Abstract: PURPOSE: To explore the expression and clinical significance of aquaporin 3 (AQP3) in oral squamous cell carcinoma(OSCC). METHODS: Two hundred and two oral mucosal tissue paraffin specimens were collected in Panjin Liaoyou Baoshihua Hospital from March 2014 to April 2017. Among them, forty-one healthy volunteers (control group) and 45 oral mucosal epithelial abnormalities (group A) , one hundred and sixteen cases of OSCC(group B) were included. The expression of AQP3 in oral mucosa tissue of the 3 groups was detected by immunohistochemical staining. The relationship between AQP3 expression and clinicopathological factors and prognosis of OSCC were analyzed. SPSS 18.0 software package was used for data analysis. RESULTS: The positive expression rate of AQP3 in group B was significantly higher than that of group A and control group (P<0.05), and AQP3 positive expression rate in oral mucosa tissues of group A was significantly higher than that of the control group(P<0.05). AQP3 positive expression rate in OSCC patients with tumor invasion depth> 5 mm, clinical T4 staging, cervical lymph node metastasis, and poorly differentiated patients were respectively higher than that in patients with tumor invasion depth≤5 mm, clinical T2 staging, no cervical lymph node metastasis, moderately well differentiated patients (P<0.05). The 3-year survival rate of OSCC patients with positive AQP3 expression(65.85%) was significantly lower than patients with negative AQP3 expression(90.00%, P<0.05). Cox regression analysis showed that tumor clinical stage, degree of differentiation, cervical lymph node metastasis, and AQP3 positive expression rate are independent prognostic factors that affect overall survival (P<0.05). CONCLUSION: The positive expression rate of AQP3 in oral mucosal tissues of OSCC patients is higher than that in patients with oral mucosal epithelial dysplasia. The expression of AQP3 is related to clinical stage, cervical lymph node metastasis, degree of differentiation, depth of tumor invasion and overall survival rate in OSCC patients.

Key words: Aquaporin 3, Oral mucosal epithelial hyperplasia, Oral squamous cell carcinoma, Pathology, Prognosis

CLC Number:

R739.8

XU Gang, SONG Qi-yi, JIANG Wei-dong, LIU Jing-xiu. Expression and clinical significance of aquaporin 3 in oral mucosal epithelial dysplasia and oral squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(5): 478-482.

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