Comprehensive co-expression analysis revealed NLRP1 as a prognostic immune-associated gene in head and neck squamous cell carcinoma

doi:10.19438/j.cjoms.2022.05.003

Abstract

Abstract: PURPOSE: To explore the prognostic value and mechanism of NLR family, pyrin domain containing 1 (NLRP1) in head and neck squamous cell carcinoma(HNSCC). METHODS: This study performed bioinformatics analysis on HNSCC data from The Cancer Genome Atlas (TCGA), and jointly analyzed with online databases such as TIMER, TCGAportal, Kaplan-Meier Plotter, LinkedOmics, GeneMANIA, Metascape, TISIDB and miRDB. RESULTS: NLRP1 was up-regulated in HNSCC. Kaplan-Meier survival analysis indicated that patients with high NLRP1 expression had a better prognosis than those with low expression. Furthermore, NLRP1 was concentrated in multiple immune-associated signaling pathways and the expression of NLRP1 was associated with the infiltration of CD4⁺T cells, neutrophils and dendritic cells. CONCLUSIONS: Our findings confirmed that NLRP1 is highly expressed in HNSCC. The high expression of NLRP1 was significantly related to prognosis and the infiltration degree of CD4⁺ T cells, neutrophils and dendritic cells in HNSCC.

Key words: NLRP1, Head and neck squamous cell carcinoma, Biomarkers, Prognosis, Immune infiltrate

CLC Number:

R739.8

YANG Hui-li, WANG Yu-fan, WANG Feng, SHEN Yue-hong, YANG Hong-yu. Comprehensive co-expression analysis revealed NLRP1 as a prognostic immune-associated gene in head and neck squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(5): 429-436.

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