Relationship between cervical lymph node characteristics and prognosis in oral squamous cell carcinoma

doi:10.19438/j.cjoms.2023.01.007

Abstract

Abstract: PURPOSE: To investigate the clinical and pathological features of cervical negative lymph nodes in oral squamous cell carcinoma (OSCC), and to study its relationship with neck recurrence and overall survival in OSCC patients. METHODS: A total of 100 OSCC patients who were treated in the First Affiliated Hospital of Xinjiang Medical University from January 2017 to January 2021 were retrospectively analyzed. The end points of the study were neck recurrence and death.Survival curve was analyzed by Kaplan-Meier and Cox proportional hazards regression analysis was used to investigate the factors of prognosis in OSCC. SPSS 21.0 software package was used for data analysis. RESULTS: The average follow-up time of 100 patients was 30 months, and 10 patients were lost to follow-up. Among the 90 patients,11 cases (12%) had recurrence of cervical lymph node metastasis, 28 cases(31.1%) died, 27 cases (30%) had sinus histiocytosis(SH) in negative lymph nodes, the 3-year recurrence-free rate was 89.4%, and the 3-year overall survival rate was 67.3%. Cox proportional hazards regression analysis of 90 patients showed that degree of tumor differentiation, N stage and clinical stage had significant influence on OS (P<0.05). Smoking, cervical lymph node metastasis in the first operation (N≠0), SH and bilateral neck dissection had significant influence on neck recurrence (P<0.05), and patients who smoked, with cervical lymph node metastasis in the first operation, accompanied by SH and underwent bilateral neck dissection had higher probability of neck recurrence. CONCLUSIONS: SH and primary cervical lymph node metastasis are independent risk factors for the recurrence and metastasis of cervical lymph node in OSCC patients. N stage is survival prognostic factor.

Key words: OSCC, Cervical lymph node, Morphology, Prognosis

CLC Number:

R739.8

SU Zi-shang, CUI Wen-li, ZHANG Meng-yun, YAO Zhi-tao. Relationship between cervical lymph node characteristics and prognosis in oral squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(1): 41-48.

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