Table of Content

    20 July 2022, Volume 20 Issue 4 Previous Issue   
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    Expert Consensus
    Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022)
    ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian
    2022, 20 (4):  313-319.  doi: 10.19438/j.cjoms.2022.04.001
    Abstract ( 24 )   PDF (1061KB) ( 13 )  
    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable.
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    Original Articles
    Study on the mechanism of miR-330-3p in cartilage degeneration in temporomandibular joint osteoarthritis in rats
    WANG Chu-yao, ZOU Lu-xiang, LU Chuan, HE Dong-mei
    2022, 20 (4):  320-327.  doi: 10.19438/j.cjoms.2022.04.002
    Abstract ( 23 )   PDF (1499KB) ( 7 )  
    PURPOSE: To study the mechanism of miR-330-3p in cartilage degeneration in temporomandibular joint osteoarthritis(TMJOA) in rats. METHODS: Human chondrocytes SW1353 was stimulated by inflammation and stress respectively and rat TMJOA model was established through unilateral anterior crossbite(UAC). The expression of miRNA-330-3p in vitro and in vivo was detected by RT-qPCR. The proliferation and metabolism changes of SW1353 were detected by EDU fluorescence staining and immunoblotting after miRNA-330-3p overexpression or inhibition. Furthermore, bioinformatics analysis was performed to predict and screen the downstream targets of miRNA-330-3p. RT-qPCR and immunoblotting were used to clarify the regulation of miRNA-330-3p on the target and the function of target. After intra-articular injection of miRNA-330-3p in TMJOA rats, the changes in cartilage metabolism were detected by immunohistochemistry to clarify the effect of miRNA-330-3p on TMJOA. SPSS 22.0 software package was used to analyze the data. RESULTS: The expression of miRNA-330-3p decreased in chondrocytes under stress or inflammatory stimuli in vitro and in TMJOA rats. Inhibition of miRNA-330-3p decreased chondrocyte proliferation, reduced SOX9 and increased MMP13 expression, while overexpression of miRNA-330-3p had opposite effects. Bioinformatics analysis revealed that CTNNB1 was one of the possible downstream targets, and its expression was elevated after inflammatory/stress stimuli in vitro and in TMJOA rats. SOX9 expression decreased, and MMP13 expression increased after overexpression of CTNNB1, with opposite results for inhibition of CTNNB1. There was a negative relationship between miRNA-330-3p and CTNNB1. Intra-articular injection of miRNA-330-3p in TMJOA rats alleviated cartilage degeneration. CONCLUSIONS: miRNA-330-3p attenuates cartilage degeneration in TMJOA by inhibiting the expression of CTNNB1.
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    Establishment and identification of patient-derived organoid model in head and neck squamous carcinoma
    WANG Chong, KANG Xin-dan, WANG Rui, WU Ya-ping, SUN Lu-lu, ZHANG Zhi-yuan, SUN Shu-yang
    2022, 20 (4):  328-333.  doi: 10.19438/j.cjoms.2022.04.003
    Abstract ( 30 )   PDF (2143KB) ( 11 )  
    PURPOSE: To construct and identify patient-derived organoid (PDO) model of head and neck squamous cell carcinoma(HNSCC). METHODS: Tumor cells, isolated from HNSCC samples, were cultured and passaged in matrix gel with three dimensions. The growth was also recorded at regular intervals. The correlation between patient tumor tissue and PDO models in histopathological and tumor molecular markers was compared using H-E and immunohistochemical staining assay. RESULTS: This study displayed 3 cases of PDO models that could be passaged stably, and the histopathology and tumor marker identification results showed that the model and the patient's tissues were consistent with each other. CONCLUSIONS: The PDO model constructed from samples of HNSCC could reflect the patient's histomorphology and biomarker characteristics, and could be utilized as a reliable preclinical model in the further HNSCC study.
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    Cu-bearing titanium alloy based on three-dimensional printing promoted osteogenic differentiation of bone marrow mesenchymal stem cells
    JIANG Sheng-jie, MEI Peng, ZHOU Hao-nan, PAN Zhao-cheng, GAO Yuan, CAI Ming
    2022, 20 (4):  334-339.  doi: 10.19438/j.cjoms.2022.04.004
    Abstract ( 23 )   PDF (1504KB) ( 5 )  
    PURPOSE: To explore the biocompatibility and the properties to enhance osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by Cu-bearing titanium alloy based on three-dimensional printing. METHODS: Cu-bearing titanium alloy based on three-dimensional printing(3D Ti-5Cu) was fabricated using Ti-6Al-4V-5Cu alloy powders as raw material via selective laser melting(SLM) technology. The 3D Ti-5Cu alloy was co-cultured with BMSCs to observe its effect on cell activity, adhesion, proliferation, alkaline phosphatase(ALP) activity and gene expression related to osteogenic differentiation, medical titanium alloy (Ti-6Al-4V) was set as the control group. The data were analyzed with GraphPad Prism 9.3.1 software. RESULTS: 3D Ti-5Cu alloy with good cytocompatibility was successfully fabricated in this study, and no statistical difference was found compared with the control group(P>0.05). Meanwhile, 3D Ti-5Cu alloy could enhance adhesion and proliferation of BMSCs, and significantly increased ALP activity and the expression levels of osteogenic differentiation genes such as Runx2, Alp, Bmp2, Opn and Col1a1, and significant differences were found between the groups(P<0.05). CONCLUSIONS: 3D Ti-5Cu alloy possesses excellent biocompatibility and can further promote the osteogenic differentiation of BMSCs, which is beneficial to improve the biological inertia of titanium alloys, and provides a theoretical basis for the realization of biological functionalization of titanium alloys.
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    Reaction and changes of rabbit mandibular condyle cultured in vitro to mechanical compression
    LI Hui, HUANG Lin-jian, XIE Qian-yang, YANG Chi
    2022, 20 (4):  340-346.  doi: 10.19438/j.cjoms.2022.04.005
    Abstract ( 26 )   PDF (1359KB) ( 2 )  
    PURPOSE: To investigate the changes of rabbit mandibular condyle under mechanical compression in vitro. METHODS: Mandibular condylar explants were cultured in vitro, and subjected to static pressures of 0(control), 15 and 75 kPa for 3 days, respectively. The gross morphology, histology and expression of collagen II(COL2), collagen X (COL10), SOX9 and MMP13 were examined, and micro-CT was performed. Statistical analysis was carried out using SPSS 16.0 software package. RESULTS: In 15 kPa group, the condyle was still intact and white with flat remodeled articular surface. In 75 kPa group, the remodeled articular surface was rough, and flat area was larger than that in 15 kPa group. Condyles became dulling and yellow with cracked cartilage in the center of articular surface. The morphological structure of the condylar cartilage and chondrocytes were more compacted than those in the control group. In the 75 kPa group, the whole layer of cartilage was damaged and detached from the subchondral bone in the central area. The expression of COL2 and SOX9 increased significantly under the pressure of 15 kPa (P<0.01), and decreased significantly at 75 kPa. The expression of COL10 and MMP13 increased significantly under the pressure of 75 kPa(P<0.01). Micro-CT showed a significant increase in bone mineral density(BMD), bone volume/total volume(BV/TV) and trabecular thickness(Tb.Th) in the pressurized groups(P<0.01). CONCLUSIONS: The integrity and function of condylar explants were maintained under the mechanical loading of 15 kPa, and adaptive remodeling was observed. Degenerative changes in cartilage were observed at 75 kPa. The pressure of 75 kPa exceeded the junction bond of cartilage and subchondral bone, and resulted in detachment of cartilage from subchondral bone which may lead to osteoarthritis.
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    YAP targeting collaboratively enhanced the inhibition effects of selumetinib to neurofibroma-Schwann cells in vitro
    YOU Yuan-he, TIAN Zhuo-wei, DU Zhong, XIAO Meng, XU Gui-song, ZHENG Jia-wei, WANG Yan-an
    2022, 20 (4):  347-353.  doi: 10.19438/j.cjoms.2022.04.006
    Abstract ( 26 )   PDF (1473KB) ( 3 )  
    PURPOSE: To explore the functional status of YAP under selumetinib treatment, and to assess the efficacy of dual targeting YAP and MEK1/2 in inhibition of NF1-Schwann cells in vitro. METHODS: NF1-Schwann cell model was established by lentivirus transfection. RT-PCR and Western blotting were performed to identify the efficacy of gene knockdown. RT-PCR, Western blotting combined with immunofluorescence were carried out to detect the functional status of YAP. siRNA was adopted to knockdown YAP gene expression. CCK-8 was used to evaluate cell viability of Schwann cells under treatment of different drug combination (YAP inhibitor veteporfin and MEK1/2 inhibitor selumetinib). Colony and sphere formation were used to detect the ability of tumor formation in vitro. Combined index analysis was performed to predict the synergistic effect via Chou-Talalay method. GraphPad Prism 8 software package was used for data analysis. RESULTS: Herein, we established a NF1-neurofibroma Schwann cell model(shNf1-RSC96). Increased nuclear translocation and transcriptional activation of YAP were confirmed under selumetinib intervening. Genetic inhibition of YAP significantly enhanced the cytotoxicity of selumetinib to NF1-Schwann cells in vitro. Additionally, combined treatment with Verteporfin and selumetinib showed a synergistic effect in vitro. CONCLUSIONS: Blocking the nuclear translocation and transcriptional activation of YAP enhances inhibition effect of selumetinib to neurofibroma-Schwann cells. Dual targeting of YAP and MEK1/2 might be a promising therapeutic strategy for treating NF1-neurofibroma.
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    Structural alterations of upper airway space in idiopathic condylar resorption patients receiving combined orthodontic and orthognathic treatment with functional splint therapy: a CT-based study
    ZHU Bo-kai, LIU Jing-yi, LYU Zheng-zhan, CHUNG Miri, WANG Xi-jun, HA Nayoung, JIANG Ling-yong
    2022, 20 (4):  354-359.  doi: 10.19438/j.cjoms.2022.04.007
    Abstract ( 23 )   PDF (1104KB) ( 4 )  
    PURPOSE: To investigate the changes of upper airway characteristics in patients with idiopathic condylar resorption(ICR) receiving combined orthodontic and orthognathic treatment with functional splint therapy. METHODS: A total of 14 ICR patients admitted from 2015.12 to 2018.12 in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were included in this study. They received combined orthodontic and orthognathic treatment with functional splint therapy, with an average treatment duration of 55.2±8.4 months. CT plain scanning was taken before functional splint therapy (T0), after functional splint therapy (T1) and 6 months after orthognathic surgery (T2). Changes in anteroposterior distance, total volume and minimal axial area(MAA) of upper airway, anteroposterior and vertical position of the mandible as well as the hyoid bone were assessed on CT scans. The significance of changes in all parameters among T0, T1 and T2 were tested using repeated-measures one-way analysis of variance(ANOVA) with SPSS 26.0 software package. RESULTS: Repeated-measures ANOVA revealed that the anteroposterior distance, total volume and MAA of PAS were significantly increased after combined orthodontic and orthognathic treatment with functional splint therapy, with mandible shifted anteriorly(P<0.05). After functional splint therapy, significant decreases were shown in all parameters above, while the mandible translated posteriorly(P<0.05). Hyoid bone did not present significant positional change after the treatment. CONCLUSIONS: After combined orthodontic and orthognathic treatment with functional splint therapy, the mandible translated anteriorly, while upper airway volume increased. After phase I of functional splint therapy, the upper airway volume decreased with mandible shifted posteriorly.
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    Identification of a de novo mutation in ANO5 by whole exome sequencing and clinical phenotype of familial gigantiform cementoma
    LI Xin, WANG Zhou-yang, QIN Xing-jun
    2022, 20 (4):  360-365.  doi: 10.19438/j.cjoms.2022.04.008
    Abstract ( 23 )   PDF (1125KB) ( 4 )  
    PURPOSE: To develop an approach based on whole exome sequencing (WES) to explore the correlation between genotype and clinical phenotype of a Chinese familial gigantiform cementoma (FGC) family caused by a mutation in ANO5 gene. METHODS: Nine patients from a Chinese FGC family with facial deformities and lower limb fractures were included. The clinical manifestations, skeletal radiographic features, bone mineral density (BMD), and bone turnover biomarkers were investigated. Peripheral blood from 9 patients and 14 controls within the family was collected, and WES was performed. By using filtering strategy, the candidate genes were sequenced and further validated by PCR and Sanger sequencing in the unaffected individuals within the family and 384 healthy control subjects. RESULTS: The major manifestations of Chinese FGC patients were representative multiquadrant and expansive deformities involving the mandible and maxilla, especially severe in the anterior mandible with diffuse osteopenia bone loss and several fractures in the lower limbs. Sequencing results showed that there was a missense, heterozygous mutation in ANO5 (c.1538C>T, p.Thr513Ile) in all affected individuals, that affected the folding, structure and function of ANO5. CONCLUSIONS: FGC is a rare autosomal dominant hereditary disease caused by ANO5 mutations, with severe facial deformity, long bone fractures and low BMD as main characteristics of Chinese' patients. The first and a novel missense mutation of ANO5 was identified, which extended the phenotypic and genetic spectrum of FGC.
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    Effect of Nrf2 on TPF induced chemotherapy for oral squamous cell carcinoma
    ZHAO Xiao-mei, XIA Rong-hui, ZHONG Lai-ping, ZHU Dong-wang, ZHANG Zhi-yuan
    2022, 20 (4):  366-370.  doi: 10.19438/j.cjoms.2022.04.009
    Abstract ( 24 )   PDF (1232KB) ( 7 )  
    PURPOSE: To examine the expression of nuclear factor erythroid-2 related factor (Nrf2) in oral squamous cell carcinoma (OSCC) and investigate the effect of Nrf2 on TPF induced chemotherapy. METHODS: A total of 65 patients with OSCC who received TPF chemotherapy were selected. Nrf2 expression in the biopsy specimens before treatment was examined by immunohistochemistry. The correlations between Nrf2 expression and clinical factors and clinical response to TPF induced chemotherapy were analyzed. SPSS 23.0 software package was used for data analysis. RESULTS: Survival analysis showed that Nrf2 expression was significantly correlated with the prognosis of TPF induced chemotherapy in OSCC patients. Patients with higher Nrf2 expression had better overall survival, disease-free survival, local relapse-free survival and distant metastasis free survival. Univariate and multivariate Cox analysis showed that Nrf2 was an independent prognostic risk factor for TPF chemotherapy in OSCC patients. CONCLUSIONS: The expression of Nrf2 is correlated with the efficacy of TPF induced chemotherapy in OSCC patients. Patients with low Nrf2 have a better prognosis, and Nrf2 can be used as a biomarker to predict the efficacy of TPF induced chemotherapy in OSCC patients
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    Construction of home care program for patients with oromaxillofacial head and neck tumor undergoing tracheotomy based on Delphi method
    XU Zhu-feng, HOU Li-li, WANG Yue-ping, XIE Yu-ting, LIU Liu, YU Xi-xi
    2022, 20 (4):  371-377.  doi: 10.19438/j.cjoms.2022.04.010
    Abstract ( 26 )   PDF (912KB) ( 14 )  
    PURPOSE: To construct a home care program of tracheotomy for patients with oromaxillofacial head and neck tumor. METHODS: Based on content analysis of the literature, semi-structured?interviews and theoretical framework, the first draft of home care program for patients with oromaxillofacial head and neck tumor was constructed. Delphi method was used to carry out two rounds of mail inquiry to 15 experts in relevant fields to determine the final scheme. SPSS 25.0 software package was used for data analysis. RESULTS: The questionnaire return rate of the two rounds of expert consultation was 100% and the overall expert authority coefficient was 0.88. The coefficient of variation of importance was 0-0.16 and the coefficient of variation of feasibility was 0-0.17. The scheme included 4 primary indicators, 9 secondary indicators and 31 tertiary indicators. CONCLUSIONS: The home care program of tracheotomy for patients with oromaxillofacial head and neck tumor constructed in this study meets the needs of this group of patients. The construction of the program is scientific and feasible, also provides a reference for clinical practice.
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    Survival analysis of 336 patients with HPV-mediated and non-mediated oropharyngeal squamous cell carcinoma
    LI Heng-yong, YANG Song, ZHOU Kai, KONG Yu, LI Jie-ying, LI Gui-zhong, GE Sheng-you, YANG Xiao-chen, FENG Yuan-yong, SONG Kai, SHANG Wei
    2022, 20 (4):  378-383.  doi: 10.19438/j.cjoms.2022.04.011
    Abstract ( 26 )   PDF (1414KB) ( 4 )  
    PURPOSE: To analyze and compare the difference in survival and prognosis of patients with HPV-mediated and non-mediated oropharyngeal squamous cell carcinoma(OPSCC) in different stages of new and old TNM, so as to provide clinical basis for the treatment strategy and prognosis evaluation of OPSCC. METHODS: Clinical data of primary OPSCC patients treated at Affiliated Hospital of Qingdao University between January 2010 and December 2016 were collected. Immunohistochemical staining of the pathological specimens was used to detect p16 expression level. Patients' survival information was evaluated using version 7, 8 edition of TNM staging system for tumor staging. The effects of different stages of HPV-mediated and non-mediated OPSCC on survival and prognosis were analyzed and compared. SPSS 25.0 software package was used for data analysis. RESULTS: Among 336 OPSCC patients, one hundred and one patients (30.1%) were HPV-mediated OPSCC. The 5-year survival rate of HPV-mediated OPSCC patients was 47.5% (48/101), and the median survival time was 58 months. The 5-year survival rate of patients with non-mediated OPSCC was 34.0% (80/235), with a median survival time of 37 months. In HPV-mediated OPSCC patients with version 8 TNM stage and version 7 TNM stage, the overall rate of degradation was 77.2% (78/101), 100% (69/69) in patients with advanced stage, and 69.6%(48/69) in patients with advanced stage degraded to early stage. CONCLUSIONS: The survival rate and median survival time of HPV-mediated OPSCC patients are significantly better than those of non-mediated OPSCC patients. The OPSCC stage in the 8th edition of TNM staging manual is more consistent with clinical reality than that in the 7th edition, and the prognosis stratification is more clear, which can better guide clinical decision-making.
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    Functional treatment and efficacy evaluation of odontogenic maxillary sinusitis in 53 consecutive patients
    HU Ying-kai, XU Guang-zhou, MA Zhi-gui, XIE Qian-yang, YANG Chi
    2022, 20 (4):  384-389.  doi: 10.19438/j.cjoms.2022.04.012
    Abstract ( 18 )   PDF (1457KB) ( 2 )  
    PURPOSE: To analyze the therapeutic methods of odontogenic maxillary sinusitis(OMS) and evaluate its efficiency, and to provide reference for clinical diagnosis and treatment. METHODS: Fifty-three cases of OMS at Shanghai Ninth People's Hospital from January 2011 to December 2020 were reviewed, and the etiology and constituent ratio were summarized. OMS was treated by functional surgery to remove various odontogenic lesions and preserve sinus mucosa and alveolar bone. The preoperative and postoperative maxillary sinusitis were quantitatively evaluated by Lund-Mackay scoring method, and the mean difference of Lund-Mackay before and after operation was compared by paired t test using SPSS 17.0 software package. In addition, the postoperative reactions and complications were evaluated. RESULTS: The common causes of OMS were odontogenic cystic lesions(49.05%), apical inflammation(20.75%), oral maxillary sinus fistula (16.98%) and foreign bodies (13.21%). The Lund-Mackay score was 3.72±0.51 before operation and 0.05±0.32 after operation, which decreased significantly(P<0.001). The postoperative response was small and there was no serious complication. CONCLUSIONS: The treatment of OMS should focus on the elimination of odontogenic lesions. Functional surgery was recommended to protect maxillary sinus mucosa.
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    Expression and clinical significance of chemerin in oral squamous cell carcinoma patients combined with type 2 diabetes
    YANG Song, WANG Ning, ZHAO Shu-chao, LI Heng-yong, GE Sheng-you, ZHOU Kai, SONG Kai, SHANG Wei, FENG Yuan-yong
    2022, 20 (4):  390-395.  doi: 10.19438/j.cjoms.2022.04.013
    Abstract ( 26 )   PDF (1157KB) ( 7 )  
    PURPOSE: To explore the expression and clinical significance of chemerin in oral squamous cell carcinoma (OSCC) patients with type 2 diabetes (T2DM), analyze the relationship with clinicopathological characteristics and prognosis, in order to provide evidence for further postoperative treatment of OSCC patients with T2DM (T2DM-OSCC). METHODS: OSCC specimens combined with type 2 diabetes and without type 2 diabetes (general OSCC) were selected from the Department of Oral and Maxillofacial Surgery of the Affiliated Hospital of Qingdao University from January 2009 to December 2014. Chemerin expression levels in tumors and para-cancerous tissues were detected by immunohistochemistry (IHC), SPSS 26.0 software package was used for data analysis. RESULTS: In the T2DM-OSCC patients, chemerin expression was significantly higher in tumor tissues compared with para-cancerous tissues (P<0.05) and chemerin expression was associated with cervical lymph node metastasis, higher TNM stage, lower tumor differentiation, and tumor recurrence (P<0.05). Chemerin expression in tumor tissues of T2DM-OSCC patients was significantly higher than that in ordinary OSCC patients (P<0.05). Log-Rank analysis and Kaplan-Meier analysis showed that the 5-year OS was shorter in the group of high chemerin expression combined with type 2 diabetes than other three groups(P<0.05). Cox model showed that chemerin expression in tumor tissues was an independent prognostic factor (P<0.05) affecting OS of T2DM-OSCC patients. CONCLUSIONS: Chemerin expression was higher in T2DM-OSCC patients than in ordinary OSCC, high expression of chemerin suggests poor prognosis in T2DM-OSCC patients. Chemerin is expected to be a potential indicator and target molecule for judging the prognosis of T2DM-OSCC patients.
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    Intra-operative vascular mapping with indocyanine green: a real time guide for perforator selection of anterolateral thigh flap
    CHEN Yi-ming, Ahemd, JI Tong, REN Zhen-hu
    2022, 20 (4):  396-400.  doi: 10.19438/j.cjoms.2022.04.014
    Abstract ( 20 )   PDF (897KB) ( 5 )  
    PURPOSE: To evaluate the value of intra-operative application of indocyanine green of mapping and selecting perforators of anterolateral thigh flap. METHODS: A prospective study was adapted for head neck tumor patients who underwent anterolateral thigh flap reconstruction from 2020.9 to 2020.12 in Shanghai Ninth People's Hospital. Indocyanine green was injected, when lateral femoral circumflex artery and perforator were found, fluorescence detector was used to evaluate the signal time and strength of perforator and branches of lateral circumflex femoral artery, as well as mapped the tract. Surgical anatomy was conducted to confirm the previous results. SPSS 19.0 software package was used for data analysis. RESULTS: Thirty patients were collected, 16 were males and 14 were females, aging from 36 to 70 years old. There was no significant difference for perforators distribution within patients. As perforator classification, classⅠ: 60, classⅡ:15, and class Ⅲ :10. Each flap had 2 classⅠperforator on average. The accuracy for perforator tract based on indocyanine green was 97.6%. CONCLUSIONS: Intra-operative application of indocyanine green is useful in mapping and selecting perforators of anterolateral thigh flap, which also reduced the surgical time and risk.
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    Comparison of pull and introducer percutaneous endoscopic gastrostomy techniques in patients with the oral and maxillofacial malignancies
    ZENG Li-ting, WU Jia-jun, FAN Jing-xian, WANG Wei, YANG Tian-ye, WANG Fan-lin, XU Bing, GE Kui
    2022, 20 (4):  401-404.  doi: 10.19438/j.cjoms.2022.04.015
    Abstract ( 19 )   PDF (558KB) ( 5 )  
    PURPOSE: The aim of this study was to compare pull and introducer percutaneous endoscopic gastrostomy(PEG) technique in patients with oral and maxillofacial malignancies(OMM). METHODS: This study was based on a retrospective analysis of 113 patients with OMM who underwent PEG in our hospital from January 2018 to December 2020, including age, gender, complications, etc. The patients were divided into two groups according to manipulation technique of PEG, namely Pull-PEG group and Intro-PEG group. SPSS 20.0 software package was used to compare the advantages and disadvantages of the two PEG techniques. RESULTS: Age, sex and albumin levels were similar in both groups. Patients in the Intro-PEG group had higher tumor stage and lower Karnofsky scores, but the difference was not statistically significant. The overall complication rate was 8.8%, including 6.2% of local complications and of 2.7% systemic complications. Postoperative complications occurred in 7 of the 75 patients (9.3%) in the Pull-PEG group and 3 of the 38 patients (7.9%) in the Intro-PEG group. Overall, major, minor, immediate and late complications were similar in both groups (P>0.05). CONCLUSIONS: Pull and introducer PEG technique seem to be both safe and effective but present different complication profiles for patients with oral and maxillofacial malignancies.
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    Dental Education
    Application and research advance of deep learning in the diagnosis and treatment of dento-maxillofacial deformities
    TAO Le-ran, ZHANG Rong-bin, LIN Yu-xin, LING Zong-xiang, CHENG Meng-jia, YU Hong-bo
    2022, 20 (4):  405-409.  doi: 10.19438/j.cjoms.2022.04.016
    Abstract ( 22 )   PDF (673KB) ( 2 )  
    Digital technology provides an ideal auxiliary method for the diagnosis and treatment of dento-maxillofacial deformities. However, due to technical limitations, current digital orthognathic surgery has problems such as semi-automated image processing and insufficient utilization of 3D images. The urgent need for clinicians to improve efficiency and optimize the diagnosis and treatment has prompted a series of researches on deep learning-assisted diagnosis and treatment of dento-maxillofacial deformities, which demonstrated the great potential of applying deep learning in this field. Therefore, this paper reviewed the development history of interdisciplinary researches between deep learning and medicine at first, and then focused on the application and research advance of deep learning in the diagnosis and treatment of dento-maxillofacial deformities, and furthermore exploring the intelligent diagnosis and treatment.
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    Case Reports
    Thyroglossal duct cyst with inherited factor V deficiency:report of one case
    DAI Xiao-tong, ZHANG Jing-ling, LI Zhen, MA Yan-ran, LIU Si-yu, XU Xiao-yu, LU Shu-lai
    2022, 20 (4):  410-412.  doi: 10.19438/j.cjoms.2022.04.017
    Abstract ( 18 )   PDF (880KB) ( 1 )  
    Thyroglossal duct cyst is a common deformity of the neck, usually occurring in children between 1 and 10 years of age, and also seen in adults. It is mainly caused by the disorder of thyroid hypothyroidism during the fetal period. It can be located at any sites along its descending route. Surgical treatment is the main treatment for this disease. Coagulotting factor V(FV) deficiency is a rare hemorrhagic disorder, and can be divided into inherited and acquired FV deficiency(AFVD). Here, we reported a 45-year-old female patient with a neck mass who was diagnosed with FVD by chance. After surgical resection of the neck mass, the specimens were sent for frozen paraffin pathology and diagnosed as thyroglossal duct cyst.The patient received fresh frozen plasma (FFP) infusion before and after operation,the operation went smoothly and the postoperative recovery was satisfactory.
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    Neoadjuvant immunotarget therapy in patients with locally advanced oral squamous cell carcinoma: report of 2 cases and literature review
    ZHANG Yi-yi, YANG Yue-yi, JU Wu-tong, ZHONG Lai-ping
    2022, 20 (4):  413-416.  doi: 10.19438/j.cjoms.2022.04.018
    Abstract ( 20 )   PDF (938KB) ( 1 )  
    Neoadjuvant therapy is systemic therapy before local treatment in patients with non-distant metastatic malignancies, aiming to reduce tumor load and distant metastasis, increase opportunity of radical resection, and relieve symptoms, et al. In this report, we presented two patients with locally advanced oral squamous cell carcinoma, who were treated with camrelizumab and apatinib as neoadjuvant therapy in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, and reviewed and discussed the relevant literatures.
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