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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （586）      PDF （2051KB）（817）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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Evaluation of the application of double wire anchor nails in temporomandibular joint disc anchorage WUERGULI Alifu, REYILAI Abudukeremu, LIU Jiang-long, MAIMAITITUXUN Tuerdi China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 397-402.   DOI: 10.19438/j.cjoms.2023.04.013 Abstract （246）      PDF （1789KB）（65）       Knowledge map    PURPOSE: To evaluate the clinical efficacy of double wire anchorage in the treatment of temporomandibular joint disc anterior displacement. METHODS: Thirty patients with anterior disc displacement without reduction(ADDWoR) diagnosed in First Affiliated Hospital of Xinjiang Medical University from June 2021 to February 2022 were included to fix the discs with double wire anchors. The maximal open mouth, visual analogue scale (VAS) scores of the patients before and at different time periods were analyzed, the patients' self-satisfaction was recorded, and the length of MRI discs and condylar height before and after operation were measured. SPSS 25.0 software was used to analyze the data and evaluate the surgical results. RESULTS: The mean age was 24.43±8.87 years old, the mean mouth opening before operation was (29.17±5.38) mm (19-42 mm), the mean maximum mouth opening after operation was (39.17±2.57) mm (35-45 mm), and 93.3% of the patients after operation had the maximum mouth opening >35 mm; the mean VAS before operation was 58.33±21.19 (10-90), the mean VAS 6 months after operation was 11.67±6.99(0-20), the mouth opening and the value of VAS 6 months after operation had significant difference compared with prior to operation(P<0.05). The disc length was (9.77±0.63), (11.96±0.68) and (12.72±0.55) mm preoperatively, immediately postoperatively and 6 months after surgery. The condyle height increased by (1.08±0.61) mm 6 months after surgery compared with immediately postoperatively (P<0.05). CONCLUSIONS: Double wire anchorage in the reduction and anchorage of TMJ disc can improve the mouth opening, relieve pain, increase the length of TMJ disc and increase the height of condyle. Reference | Related Articles | Metrics

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Effect of extranodal extension on TNM staging and survival in patients with oral squamous cell carcinoma LI Gui-zhong, LI Jie-ying, ZHOU Kai, MENG Yu-xiang, WANG Ke-xin, GE Sheng-you, SONG Kai, FENG Yuan-yong, TAO Yue-qin, ZHAN Xiao-hong, SHANG Wei China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 377-383.   DOI: 10.19438/j.cjoms.2023.04.010 Abstract （224）      PDF （1371KB）（91）       Knowledge map    PURPOSE: By analyzing the influence of extranodal extension (ENE) on TNM staging manual and survival after included into the staging, to learn about the significance of ENE on clinical decision-making and prognosis of oral cancer. METHODS: A retrospective cohort study of 485 patients with primary oral squamous cell carcinoma(OSCC) from January 2014 to June 2017 was performed in the Affiliated Hospital of Qingdao University. The AJCC 7th and 8th edition staging systems was applied to the patients. Overall survival and disease-specific survival were analyzed by Kaplan-Meier analysis and Log-rank test with SPSS 26.0 software package. Concordance index and Akaike information criterion(AIC) was used to evaluate the system’s prognostic capacity. RESULTS: A total of 485 patients with OSCC were followed up. The pathological N stage of 69 (14.43%) patients (including 16 pN2a and 53 pN3b) was changed by extranodal extension. The pathological TNM stage of 67(13.81%) patients (including 14 ⅣA and 53 ⅣB) was also changed because of ENE. Overall survival and disease-specific survival model analysis of N stage, TNM stage and ENE showed that patients with positive ENE (OS:27.1%, DSS:31.2%) had a lower survival rate than those with negative ENE(OS:72.2%, DSS:78.0%). AIC of AJCC 8th edition staging systems was lower than 7th edition and there was little difference between them in terms of concordance index. CONCLUSIONS: Extranodal extension changed TNM staging of OSCC patients. The number of advanced patients increased significantly and the survival prognosis became worse. ENE can objectively refect the status of the patients. It has more guiding significance for decision-making and prognosis evaluation of oral cancer patients. Reference | Related Articles | Metrics

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Single-cell transcription atlas for mandibular condyle cartilage and subchondral bone marrow in rat temporomandibular joint osteoarthritis YU Ye-ke, DING Ruo-yi, SUN Jia-li, ZHANG Zhi-yuan, HE Dong-mei China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 332-339.   DOI: 10.19438/j.cjoms.2023.04.003 Abstract （202）      PDF （2829KB）（161）       Knowledge map    PURPOSE: To establish the single-cell transcriptome atlas for rat condyle osteochondral tissue and bone marrow both in normal and temporomandibular joint osteoarthritis (TMJOA) condition. METHODS: Rat unilateral anterior crossbite(UAC) model was built to induce TMJOA. Osteochondral cells and bone marrow immune cells were extracted for single-cell RNA sequencing. Quality control, dimension reducing, clustering and marker gene detection were used to depict cell subclusters. Differential gene expression analysis and functional enrichment were utilized to demonstrate cell cluster functions and their changes under UAC. Pseudo-time analysis was applied for cell development trajectory, while cell communication prediction was used to show alternations in the interaction among cell clusters. RESULTS: There were 9 cell clusters in rat condyle, containing osteochondral cells and bone marrow immune cells. Under UAC, the number of osteochondrocytes decreased whereas immune cells accumulated. Condyle cartilage and bone tissue contained 6 functional groups of cells. Among them, D and F group maintained progenitor characteristics and possessed the ability to develop into other groups. In UAC condition, osteochondrocytes witnessed impaired extracellular matrix organization, activated senescent or inflammatory pathways, and diminished cell-cell interaction. Meanwhile, in the bone marrow, neutrophils showed enhanced chemotaxis and degranulation, mononuclear-phagocytes displayed increased phagosomes, activated B cells were also recruited. CONCLUSIONS: There are progenitor cells in condyle cartilage and bone tissue, whose function impaired under UAC. At the same time, immune cells in the bone marrow are activated. Targeted modulation of osteochondral progenitors and immune cells could contribute in alleviation the condyle tissue damage in TMJOA. Reference | Related Articles | Metrics

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Application prospect of tumor treating fields technology in head and neck cancer LI Chen-xi, GONG Zhong-cheng, ZHAO Hua-rong, DING Ming-chao, LIU Hui China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 425-431.   DOI: 10.19438/j.cjoms.2023.05.001 Abstract （196）      PDF （1218KB）（89）       Knowledge map    In recent years, major breakthroughs have been made in the treatment of malignant tumours with research and development progress of immunologic agents and molecular targeted drugs, but it is still the main cause of global disease death. Tumour treating fields (TTFields) is a new non-invasive approach to cancer treatment. TTFields can provide a kind of low-intensity (1-3 V/cm), intermediate frequency (100-300 kHz) alternating electric fields delivered locally to the tumour, which can destroy the chromosome segregation of mitotic tumour cells and induce dielectrophoresis to arise cell structure disturbance and apoptosis. The sensitive parameters of TTFields for normal and cancerous cells are different, but TTFields has no effect on quiescent cells. Hence, it has the advantages of fewer side effects and less trauma, and has great potential. Additionally, its efficacy and safety have been verified in phase III clinical trials of glioblastoma multiforme. Some clinical trials on TTFields have also been carried out in other kinds of solid tumours. This article reviewed the latest research progress of TTFields, expounding its micromechanism and discussing its application prospects in head and neck cancer. Reference | Related Articles | Metrics

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Retrospective analysis of 190 cases of oral and maxillofacial space infection complicated with hyperglycemia YANG Zuo-yi, YE Lei, ZHENG Ling-yan, CHEN Chang-yu, FU Jia-yao China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 360-365.   DOI: 10.19438/j.cjoms.2023.04.007 Abstract （188）      PDF （684KB）（114）       Knowledge map    PURPOSE: To analyze the difference between oral and maxillofacial space infection(OMSI) patients with diabetes mellitus, stress hyperglycemia and normal blood glucose in general data, clinical manifestations, laboratory test, and dominant bacterial flora of infection. METHODS: A retrospective study was conducted in 190 patients diagnosed with oral and maxillofacial infection and treated at the Department of Oral Surgery, Shanghai Ninth People's Hospital from August 2020 to June 2022. Statistical analysis of general data, clinical manifestations, laboratory test, and dominant bacterial flora of infection between the three groups was performed with SPSS 25.0 software package. RESULTS: Between diabetic group and stress hyperglycemia group, absolute number of lymphocytes, sodium and chlorine differed significantly; between diabetic group and normal blood glucose group, age, neutrophil absolute number, neutrophil percentage, lymphocyte percentage, C-reactive protein, IL-6, IL-8, tumor necrosis factor-α, procalcitonin, urea, serum uric acid, fibrinogen, sodium, chlorine and total carbon dioxide differed significantly; between stress hyperglycemia group and normal glycemia group,the percentage of neutrophil, percentage of lymphocyte, absolute number of lymphocyte, C-reactive protein, IL-8, tumor necrosis factor-α, and urea differed significantly. CONCLUSIONS: The clinical features and laboratory results of OMSI patients with diabetes, stress hyperglycemia and normal blood glucose are significantly different, suggesting that the three groups of patients should be distinguished in clinical diagnosis and treatment, and more targeted treatment should be provided. Reference | Related Articles | Metrics

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Multiple calcified epithelioma: a case report and gene analysis SONG Jiao-jiao, LU Qian, CAO Zhang, ZUO Jin-hua, WANG Wen-long, MA Xiang-rui, WANG Li China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 526-528.   DOI: 10.19438/j.cjoms.2023.05.018 Abstract （174）      PDF （879KB）（41）       Knowledge map    Calcified epithelioma (CE), also known as pilomatricoma (PM), is an ectodermal benign tumor originating from the outer root sheath cells of hair follicles. Generally, it only occurs in the upper limb trunk and face and neck, and multiple calcified epithelioma is even rarer in clinic. This paper reported a case of multiple calcified epithelioma and carries out related gene detection, and discussed based on related literature, in order to provide some basis for clinical diagnosis and treatment. Reference | Related Articles | Metrics

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Effect of alveolar fossa preservation with different implant materials on alveolar ridge resorption in patients undergoing posterior tooth extraction ZHU Min-yan, WANG Hai-yan, YUAN Yin-yin China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 403-406.   DOI: 10.19438/j.cjoms.2023.04.014 Abstract （173）      PDF （497KB）（97）       Knowledge map    PURPOSE: To investigate the effect of alveolar preservation with different implant materials on alveolar ridge absorption in patients with posterior tooth extraction. METHODS: Eighty-six patients with tooth restoration after extraction admitted to Zhejiang Greentown Cardiovascular Hospital from March 2016 to April 2020 were selected. The patients were divided into experimental group and control group according to the random number, 43 cases in each group. After tooth extraction, patients in the experimental group implanted platelet-rich fibrin(PRF) into the alveolar fossa, while patients in the control group implanted collagen plugs into the alveolar fossa after tooth extraction. The time of wound healing, the height of alveolar soft tissue and the width of alveolar ridge were observed immediately and 6 months after surgery. SPSS 23.0 software package was used for data analysis. RESULTS: The postoperative wound healing time was (10.52±3.14) d in the experimental group, which was significantly shorter than (17.68±5.35) d in the control group(P<0.05). The alveolar soft tissue height of the experimental group was significantly lower than that of the control group 6 months after operation(P<0.05), but there was no significant difference between the mesial papilla and distal papilla (P>0.05). The experimental group was significantly higher than the control group in alveolar ridge widths at 20% and 70% of the root length 6 months postoperatively (P<0.05), but there was no significant difference between the two groups at 50% of the root length (P>0.05). CONCLUSIONS: Compared with collagen plug, the application of PRF in the preservation of extraction site can promote wound healing time and reduce absorption of alveolar ridge. It is an ideal filling and covering material for the preservation of extraction site at present. Reference | Related Articles | Metrics

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Protein profiling analysis of oral squamous cancer derived extracellular vesicle subgroups WU Ruo-yi, WANG Xiao-ning, ZHAI Pei-song, ZHANG Jian-jun, CHEN Wan-tao China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 326-331.   DOI: 10.19438/j.cjoms.2023.04.002 Abstract （162）      PDF （1063KB）（121）       Knowledge map    PURPOSE: To reveal the commonality and heterogeneity in protein contents of extracellular vesicles (EVs) subgroups obtained by different immunomarkers, and provide data support for researchers to select appropriate isolation protocols. METHODS: In this study, oral cancer cells CAL27, pancreatic cancer cells PANC-1 and gastric cancer cells AGS were used, and EVs derived from them were isolated by 4 EVs markers CD9, CD63, CD81 and EpCAM. Then the proteins from these 4 different EVs subgroups were detected by mass spectrometry. The commonality and heterogeneity between EVs subgroups were evaluated by funrich3.1.3 software. SPSS 19.0 software package was used for statistical analysis. RESULTS: Under the same culture conditions, AGS cells produced the highest number of EVs, followed by CAL27 cells and the least by PANC-1 cells. Among the 4 different EVs isolation methods, the EpCAM marker-based isolation method was the most efficacious. The results of principal component analysis showed that the subgroups of EVs involved in this study were heterogeneous at the level of cell origin as well as at the level of isolation markers. The results of the cellular component analysis of the protein profile showed that 86.11% of the proteins enriched by CD63+ EVs derived from CAL27 were related to exosomes, which was significantly higher than the percentage of the CD9+, CD81+ and EpCAM+ EVs subgroups(70.92%, 70.90% and 63.68%); while 37.96% of the enriched proteins in the CD63+ EVs subgroup were related with cell membrane, which was lower than the percentage of CD9+, CD81+, and EpCAM+ EVs subgroups (53.20%, 61.19% and 49.53%), indicating that EVs subgroups isolated by different immunomarkers had different origins. CONCLUSIONS: The subgroups of EVs involved in this study are heterogeneous at the cellular origin level and at the immunomarker level. Among them, CD63+ EVs may originate more from the endosomal pathway, while CD9+, CD81+ and EpCAM+ EVs originate more from the plasma membrane outgrowth pathway. The EVs subgroups obtained based on different isolation markers were differential in terms of cell biological functions. Reference | Related Articles | Metrics

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Study on risk model for postextraction bleeding of mandibular third molars WANG Jian-rong, SUN Jing, ZHAO Shu-hong, SHANG Jiang China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 479-485.   DOI: 10.19438/j.cjoms.2023.05.009 Abstract （156）      PDF （987KB）（111）       Knowledge map    PURPOSE: To explore the risk factors of bleeding after mandibular third molar extraction and establish a prediction model to provide reference for clinical decision-making. METHODS: Clinical data of 610 cases of mandibular third molar extraction were collected for the study. Association of postextraction bleeding with the patient demographic variables (gender), tooth variables(position, impacted angle) and other variables (periodontitis, intraoperative anesthetic drugs, flap, postoperative treatment, hemostatic materials, patient compliance). SAS 9.4 software package was used to analyze the data. RESULTS: The incidence of postextraction bleeding was 10.33% in 610 patients after mandibular third molars extraction, and 63 patients had postextraction bleeding. Multivariate logistic regression analysis showed that the position, impacted angle, flap, postoperative treatment, patient compliance were independent risk factors for postextraction bleeding of mandibular third molars. The results showed that the prediction model had good differential validity(AUC=0.916), high calibration degree (P=0.605), and certain clinical application value. CONCLUSIONS: The position, impacted angle, flap, postoperative treatment and patient compliance are not only risk factors for postextraction bleeding, but also predictive factors for predictive models. Reference | Related Articles | Metrics

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Accuracy of MRI to measure and evaluate clinical staging of oral squamous cell carcinoma SI Cheng-yun, LIU Meng-qiu, WENG Hai-yan, ZHANG Li-yu, AN Xing-fei, ZHOU Yu China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 390-396.   DOI: 10.19438/j.cjoms.2023.04.012 Abstract （154）      PDF （1445KB）（67）       Knowledge map    PURPOSE: To investigate the accuracy of magnetic resonance imaging (MRI) for measuring and assessing the clinical staging of oral squamous cell carcinoma (OSCC). METHODS: A total of 71 patients with OSCC in The First Affiliated Hospital of University of Science and Technology of China from February 2020 to September 2022 were enrolled. The MRI measurements of maximum tumor diameter(MTD), depth of invasion(DOI), and maximum cut sections were recorded, pathological sections were made on the sections, the pathological MTD and DOI were measured and statistically analyzed, and the cervical lymph node status assessed by MRI was compared with the postoperative pathological lymph node status to analyze the accuracy of preoperative MRI measurements and clinical staging. SPSS 26.0 software package was used for data analysis. RESULTS: The mean DOI measured on the MRI was 2.54 mm(95%CI: 3.56-1.53, P<0.05), higher for Gd-T1WI sequence, with correlation coefficient r=0.984; the mean DOI measured on T2WI sequence was 3.09 mm(95%CI: 4.88-1.29, P<0.05) higher, with correlation coefficient r=0.953. Bland-Altman dot plots showed that the measurements of Gd-T1WI sequence were more consistent with pathological DOI values. At the same time, the clinical measurements of MTD were 0.85 cm (95%CI: 0.78-0.91, P<0.05), higher than the histologic findings, with correlation coefficient r of 0.958; the MRI measurements of MTD were 0.21 cm(95%CI: 0.10-0.32, P<0.05), higher than the histologic findings, with correlation coefficient r of 0.878. The MTD measured by MRI was significantly lower than that measured by clinical visualization. The preoperative assessment of cervical lymph node status by MRI was true-positive in 69.6% and true-negative in 89.6% of patients. CONCLUSIONS: MRI has a high accuracy in measuring clinical stage in patients with OSCC and can be used as a reliable reference method for assessing clinical stage. Reference | Related Articles | Metrics

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Diagnosis and treatment of oral soft tissue infection caused by pericoronitis after bone marrow transplantation: a case report PANG Chao-yuan, TIAN Wen-yan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 421-424.   DOI: 10.19438/j.cjoms.2023.04.018 Abstract （141）      PDF （1159KB）（77）       Knowledge map    Hematopoietic stem cell transplantation(HSCT) is one of the important methods for the treatment of severe aplastic anemia(SAA). Some oral complications will occur during bone marrow transplantation period such as oral ulcer and infections. Prevention and treatment of these oral complications reasonably is the key to the success of bone marrow transplantation. In this paper, we reported the clinical treatment of a patient with oral soft tissue infection caused by pericoronitis after bone marrow transplantation, in order to investigate oral health management of bone marrow transplantation patients and provide some reference to improve the success rate of bone marrow transplantation. Reference | Related Articles | Metrics

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Screening of hub genes in tongue squamous cell carcinoma based on bioinformatics analysis ZENG Hui, JIANG Hua-xiang, HU Yan-chang, YANG Feng-rui, WANG Jun China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 452-460.   DOI: 10.19438/j.cjoms.2023.05.005 Abstract （131）      PDF （1893KB）（63）       Knowledge map    PURPOSE: To screen hub genes for tongue squamous cell carcinoma(TSCC) by bioinformatic methods and explore their potential functional and pathway mechanisms associated with TSCC progression. METHODS: The microarray datasets GSE13601 was analysed to screen out the differentially expressed genes. The database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. STRING database was used to construct protein interaction networks, and the abnormal expression of key genes in TSCC was assessed by sequencing data from The Cancer Genome Atlas (TCGA) database. RESULTS: A total of 101 differentially expressed genes and 20 key genes were screened, and further studies revealed that key genes such as MYH2, MYLPF, NEB, ACTN2, DES and TMP2 affected the survival rate of TSCC patients, and the expression of MYH2, MYLPF, ACTN2, DES, TPM2, TNNC1, MYL1, MYH7 and TNNI2 correlated with the clinical stage of TSCC. CONCLUSIONS: MYH2, MYLPF, NEB, ACTN2, DES, TMP2, TNNC1, TPM2, MYH7 and TNNI2 may participate in the development of TSCC and have the potential to become biomarkers and therapeutic targets for TSCC. Reference | Related Articles | Metrics

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Multifocal adenomatous oncocytic hyperplasia in bilateral parotid gland: a case report and review of literatures WU Ya-nan, YU Ning, FAN Zhi-wei, WANG Wen-long, MA Xiang-rui, WANG Jing China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 418-420.   DOI: 10.19438/j.cjoms.2023.04.017 Abstract （126）      PDF （876KB）（72）       Knowledge map    Multifocal adenomatous oncocytic hyperplasia is a rare benign salivary gland lesion. A case of multifocal adenomatoid oncocytic hyperplasia in bilateral parotid gland was reported,and the clinical pathologic features,diagnosis and treatment were discussed based on the literature,in order to provide reference for clinical diagnosis and treatment. Reference | Related Articles | Metrics

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Calcium pyrophosphate dihydrate crystal deposition disease of the temporomandibular joint: case report and literature review DENG Li-ni, CHEN Chuan-jun, WANG Yi, XIANG Xian-wang China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 522-525.   DOI: 10.19438/j.cjoms.2023.05.017 Abstract （125）      PDF （1308KB）（39）       Knowledge map    Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) refers to calcium pyrophosphate crystals deposited in articular fibrocartilage, hyaline cartilage and its surrounding synovium, ligaments, tendons and joint capsules. CPPD is idiopathic in most patients, however, it has been associated with aging, osteoarthritis, gout, hyperparathyroidism and metabolic disorders like hemochromatosis and hypomagnesemia. In this paper, a female patient with CPPD of temporomandibular joint(TMJ) was reported,in which the lesion invaded cranial base, the condyle and disc of TMJ. Surgical procedure was performed to remove the lesion and reconstruct cranial base and TMJ. Reference | Related Articles | Metrics

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Experimental study on embolization and sclerotherapy of cervicofacial venous malformations with fibrin glue combined with pingyangmycin YAN Zhi-wei, SHEN Yan-ling, GUO Jun, LIU Yuan, YANG Xia, LI Huan, FENG Yao, SUN Mo-yi, YANG Yao-wu China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 340-344.   DOI: 10.19438/j.cjoms.2023.04.004 Abstract （123）      PDF （1957KB）（50）       Knowledge map    PURPOSE: To evaluate the efficacy of embolosclerotherapy using fibrin glue(FG) combined with pingyangmycin (PYM) in animal model of cervicofacial venous malformations(VMs). METHODS: A total of 15 sheep were selected to make animal models of VMs. The VMs animal models were divided into PYM group, FG group, and FG/PYM group , which were injected with PYM, FG and FG/PYM respectively. Four weeks after injection, the effect of embolization and sclerotherapy on vascular fibrosis were evaluated through Doppler ultrasound, gross and histological observations. RESULTS: Four weeks after PYM injection, the venous wall was slightly thickened, the pore size was slightly reduced, some vascular lumens were unobstructed, and some had thrombosis. Doppler ultrasound showed clear venous lumen and blood flow. Histological observation showed that the morphology of most venous endothelial cells and the structure of the vascular wall were basically normal. The continuity of some venous intima was incomplete, and the local intima disappeared in some vascular walls and the fibrous tissue hyperplasia could be seen. Four weeks after FG injection, Doppler ultrasound showed that venous blood flow disappeared or decreased significantly. Gross observation showed thickening of the venous wall and narrowing of the lumen, and yellow or dark red jelly-like emboli with certain toughness were observed in the lumen. Histological observation showed that the lumen had an amorphous substance, mature or immature fibrous tissue grew into the amorphous mass, and the structure of the vessel wall was unclear. Four weeks after FG/PYM injection, Doppler ultrasonography showed loss of venous blood flow. Gross observation showed obvious thickening of the venous wall, yellow or dark red emboli were seen in some venous lumens, and some lumens were basically blocked. Histological observation showed that some lumens contained an amorphous substance, a large number of mature or immature fibrous tissues were seen in the vascular region, and the vessel wall structure was disappeared. Histological examination showed that some lumens were amorphous, a large number of mature or immature fibrous tissues were seen in the vascular region, and the vessel wall structure disappeared. CONCLUSIONS: Embolization and sclerotherapy with FG combined with PYM has shown good effect in promoting the destruction of vascular endothelial cells and vascular fibrosis. The results reveal the potential advantages and application prospects of this technique in the treatment cervicofacial VMs. Reference | Related Articles | Metrics

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Prognosis of adenoid cystic carcinoma in head and neck region: a single-centre experience CHENG Yu-tian, XU Le, MA Li, WU Hai-wei, CHEN Zhan-wei, ZOU Hu-wei, ZHANG Tian-qi, LIU Gui-jun, LIU Zhen-xing, YIN Chang-wei, LI Wen-gang, ZHANG Shi-zhou, HUANG Sheng-yun, ZHANG Dong-sheng China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 467-471.   DOI: 10.19438/j.cjoms.2023.05.007 Abstract （121）      PDF （511KB）（49）       Knowledge map    PURPOSE: To explore the prognostic factors of adenoid cystic carcinoma (ACC) in head and neck region by analyzing associated clinical characters. METHODS: A total of 188 patients with ACC in head and neck region were enrolled, and the follow-up was carried out by outpatient review or telephone. Kaplan-Meier method was used to assess the survival rates, and Cox regression analysis was used to identify the associated prognostic factors with SPSS 26.0 software package. RESULTS: The overall survival rate of 188 patients was 76.6%, of which 13.3% died of recurrence and 10.1% died of distant metastasis. The rate of local recurrence and distant metastasis were 23.9% and 10.1%, of which the survival rate was 42.2% and 68.4%, respectively. Cox regression analysis revealed that age, T stage, N stage, and regimens were significantly associated with survival of ACC. CONCLUSIONS: In ACC, age, T stage, N stage, and regimen were independent prognostic factors of survival, age and nerve invasion were independent prognostic factors of recurrence, and N stage was independent prognostic factor of distant metastasis. Reference | Related Articles | Metrics

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The role of MAP7D3 in head and neck squamous cell carcinoma LIU Yu, CHEN Yu-ling, LIN Yun-tao, YANG Hong-yu China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 352-359.   DOI: 10.19438/j.cjoms.2023.04.006 Abstract （121）      PDF （2509KB）（60）       Knowledge map    PURPOSE: The aim of this study is to figure out MAP7D3 expression level, diagnostic and prognostic value in head and neck squamous cell carcinoma (HNSCC) by bioinformatics technology and to initially explore the effect of the expression change of MAP7D3 on the biological behavior of HNSCC cell lines. METHODS: Expression analysis, clinicopathological characteristics correlation analysis, survival analysis, Cox regression analysis, ROC curve analysis and GSEA analysis were performed in HNSCC by bioinformatics.The expression of MAP7D3 were detected by qRT-PCR and immunohistochemistry staining in HNSCC cell lines(WSU-HN6, CAL27) and HNSCC tissues. Downregulation of MAP7D3 by siRNA was identified by qRT-PCR. CCK8 assay, flow apoptosis assay, wound healing assay and transwell assay ware performed to detect the effect of knocking down MAP7D3 on the biological behaviors of HNSCC cell lines WSU-HN6 and CAL27. RESULTS: MAP7D3 was highly expressed in HNSCC at both RNA and protein level by bioinformatic analysis, qRT-PCR and immunohistochemical staining. Clinical correlation analysis revealed that the expression level of MAP7D3 was correlated with pathological grade. Overall survival, disease specific survival and progress free interval were shorter in patients with high MAP7D3 expression compared with patients with low MAP7D3 expression. Univariate and multivariate Cox regression analysis showed that MAP7D3 expression could be an independent risk factor for prognosis of HNSCC patients. ROC curves showed the diagnostic value of MAP7D3 in differentiating HNSCC tissue from normal tissue. GSEA enrichment analysis showed that MAP7D3 high expression group was enriched in various signaling pathways such as focal adhesion and ECM-receptor interactions. CCK-8 assay, flow apoptosis assay, wound healing assay and transwell assay showed that knockdown of MAP7D3 can inhibit the proliferation, migration, invasion and increase apoptosis of HNSCC cell lines WSU-HN6 and CAL27. CONCLUSIONS: MAP7D3 is highly expressed in HNSCC and can be used as a potential diagnostic and prognostic biomarker for HNSCC. Downregulation of MAP7D3 can inhibit the proliferation, migration and invasion of HNSCC cell and increase cell apoptosis. Reference | Related Articles | Metrics

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Research progress of β-catenin in tooth development SUI Xin, DU Zhong China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 413-417.   DOI: 10.19438/j.cjoms.2023.04.016 Abstract （118）      PDF （527KB）（68）       Knowledge map    β-catenin is the central hub in the canonical Wnt/β-catenin signaling pathway, which plays an important role in the regulation of odontogenesis and tooth development. In this paper, we reviewed the recent research progress in terms of the expression pattern of β-catenin during tooth development, the molecular mechanism of β-catenin in tooth development process which includes odontogenesis, crown development and root formation. It may provide a reference for elucidation of tooth development mechanism, exploration of potential therapeutic targets of tooth development related diseases, and precise regulation of tooth regeneration. Reference | Related Articles | Metrics

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Application of dietary nursing and psychological intervention in patients with oral mucosal ulceration after radiotherapy and chemotherapy for nasopharyngeal carcinoma TANG Feng-rong, WANG Peng, ZHANG Yan China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 491-496.   DOI: 10.19438/j.cjoms.2023.05.011 Abstract （118）      PDF （746KB）（38）       Knowledge map    PURPOSE: To investigate the application of dietary nursing and psychological intervention in patients with oral mucosal ulceration after radiotherapy and chemotherapy for nasopharyngeal carcinoma. METHODS: A total of 120 patients with nasopharyngeal carcinoma undergoing chemoradiotherapy in Zhongshan Hospital, Fudan University(Xiamen Branch) from April 2019 to July 2022 were selected. The patients were divided into control group and intervention group by convenient sampling in non-probabilistic sampling method with 60 cases in each group. The control group was given routine care, and the intervention group administered "one-on-one" education to patients through diet and psychological interventions. The degree of oral mucosal damage, weight index, quality of life score and anxiety score of the 2 groups were compared. SPSS 26.0 software package was used for data analysis. RESULTS: The degree of oral mucosal injury in the intervention group was significantly lower than that in the control group (P<0.05). After 6 months, the weight, quality of life in the intervention group were significantly higher than those in the control group, and the anxiety status in the intervention group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Dietary care can effectively improve the nutritional status and quality of life of patients with oral mucosal rupture caused by radiotherapy and/or chemotherapy for nasopharyngeal carcinoma. Through psychological intervention, guiding patients to face the disease correctly and relieve their emotions can effectively improve their psychological health. Reference | Related Articles | Metrics