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    Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw
    HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001
    Abstract451)      PDF (2051KB)(607)      
    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references.
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    lymphatic-venous anastomosis for head and neck lymphedema using supermicrosurgery: case report and literature review
    REN Zhen-hu, GU Shi-lin, JI Tong, HE Yue, ZHANG Zhi-yuan, ZHENG You-mao
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 306-308.   DOI: 10.19438/j.cjoms.2023.03.017
    Abstract255)      PDF (958KB)(50)      
    In recent years, surgical treatment of limbs and trunk lymphedema has gradually attracted attention, but little is paid to head and neck lymphedema. In this paper, we reported a case of lymphedema of head and neck treated by super microsurgery with lymphatic-venous anastomosis(LVA), and discuss its pathogenesis, clinical manifestations, diagnosis and treatment based on relevant literature.
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    Evaluation of the application of double wire anchor nails in temporomandibular joint disc anchorage
    WUERGULI Alifu, REYILAI Abudukeremu, LIU Jiang-long, MAIMAITITUXUN Tuerdi
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 397-402.   DOI: 10.19438/j.cjoms.2023.04.013
    Abstract213)      PDF (1789KB)(54)      
    PURPOSE: To evaluate the clinical efficacy of double wire anchorage in the treatment of temporomandibular joint disc anterior displacement. METHODS: Thirty patients with anterior disc displacement without reduction(ADDWoR) diagnosed in First Affiliated Hospital of Xinjiang Medical University from June 2021 to February 2022 were included to fix the discs with double wire anchors. The maximal open mouth, visual analogue scale (VAS) scores of the patients before and at different time periods were analyzed, the patients' self-satisfaction was recorded, and the length of MRI discs and condylar height before and after operation were measured. SPSS 25.0 software was used to analyze the data and evaluate the surgical results. RESULTS: The mean age was 24.43±8.87 years old, the mean mouth opening before operation was (29.17±5.38) mm (19-42 mm), the mean maximum mouth opening after operation was (39.17±2.57) mm (35-45 mm), and 93.3% of the patients after operation had the maximum mouth opening >35 mm; the mean VAS before operation was 58.33±21.19 (10-90), the mean VAS 6 months after operation was 11.67±6.99(0-20), the mouth opening and the value of VAS 6 months after operation had significant difference compared with prior to operation(P<0.05). The disc length was (9.77±0.63), (11.96±0.68) and (12.72±0.55) mm preoperatively, immediately postoperatively and 6 months after surgery. The condyle height increased by (1.08±0.61) mm 6 months after surgery compared with immediately postoperatively (P<0.05). CONCLUSIONS: Double wire anchorage in the reduction and anchorage of TMJ disc can improve the mouth opening, relieve pain, increase the length of TMJ disc and increase the height of condyle.
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    Effect of extranodal extension on TNM staging and survival in patients with oral squamous cell carcinoma
    LI Gui-zhong, LI Jie-ying, ZHOU Kai, MENG Yu-xiang, WANG Ke-xin, GE Sheng-you, SONG Kai, FENG Yuan-yong, TAO Yue-qin, ZHAN Xiao-hong, SHANG Wei
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 377-383.   DOI: 10.19438/j.cjoms.2023.04.010
    Abstract209)      PDF (1371KB)(75)      
    PURPOSE: By analyzing the influence of extranodal extension (ENE) on TNM staging manual and survival after included into the staging, to learn about the significance of ENE on clinical decision-making and prognosis of oral cancer. METHODS: A retrospective cohort study of 485 patients with primary oral squamous cell carcinoma(OSCC) from January 2014 to June 2017 was performed in the Affiliated Hospital of Qingdao University. The AJCC 7th and 8th edition staging systems was applied to the patients. Overall survival and disease-specific survival were analyzed by Kaplan-Meier analysis and Log-rank test with SPSS 26.0 software package. Concordance index and Akaike information criterion(AIC) was used to evaluate the system’s prognostic capacity. RESULTS: A total of 485 patients with OSCC were followed up. The pathological N stage of 69 (14.43%) patients (including 16 pN2a and 53 pN3b) was changed by extranodal extension. The pathological TNM stage of 67(13.81%) patients (including 14 ⅣA and 53 ⅣB) was also changed because of ENE. Overall survival and disease-specific survival model analysis of N stage, TNM stage and ENE showed that patients with positive ENE (OS:27.1%, DSS:31.2%) had a lower survival rate than those with negative ENE(OS:72.2%, DSS:78.0%). AIC of AJCC 8th edition staging systems was lower than 7th edition and there was little difference between them in terms of concordance index. CONCLUSIONS: Extranodal extension changed TNM staging of OSCC patients. The number of advanced patients increased significantly and the survival prognosis became worse. ENE can objectively refect the status of the patients. It has more guiding significance for decision-making and prognosis evaluation of oral cancer patients.
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    Application and efficacy evaluation of functional fixator in the fenestration treatment of jaw cyst
    ZHOU Yun, WANG Zhen, ZHAO Xiao-mei
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 263-266.   DOI: 10.19438/j.cjoms.2023.03.010
    Abstract197)      PDF (794KB)(95)      
    PURPOSE: To evaluate the effect of functional occlusal device in the fenestration of jaw cyst. METHODS: Fifty patients with jaw cyst who underwent fenestration surgery for the first time were selected. According to the treatment methods, they were divided into the conventional treatment group and functional treatment group, with 25 cases in each group. Obturator functioning scale (OFS) was used to evaluate the comfort, masticatory efficiency and aesthetics of patients wearing two kinds of different endodontics during fenestration treatment. The patients' satisfaction with the final restoration was investigated by questionnaire. SPSS 20.0 software package was used for data analysis. RESULTS: Compared to conventional obturators, the functional obturator group showed a statistically significant reduction in mandibular and maxillary tooth extension after healing of the lesion (P<0.01). However, there was no significant difference in chewing efficiency during the wearing of the obturator(P>0.05). The esthetic satisfaction of the functional obturator was significantly higher in patients with anterior tooth loss(P<0.01). CONCLUSIONS: The functional obturator, which combines the functions of denture restoration, not only has good esthetics and wearing comfort, but also better maintains stability in missing interdental spaces and is more favorable for the restoration of missing teeth.
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    Single-cell transcription atlas for mandibular condyle cartilage and subchondral bone marrow in rat temporomandibular joint osteoarthritis
    YU Ye-ke, DING Ruo-yi, SUN Jia-li, ZHANG Zhi-yuan, HE Dong-mei
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 332-339.   DOI: 10.19438/j.cjoms.2023.04.003
    Abstract186)      PDF (2829KB)(137)      
    PURPOSE: To establish the single-cell transcriptome atlas for rat condyle osteochondral tissue and bone marrow both in normal and temporomandibular joint osteoarthritis (TMJOA) condition. METHODS: Rat unilateral anterior crossbite(UAC) model was built to induce TMJOA. Osteochondral cells and bone marrow immune cells were extracted for single-cell RNA sequencing. Quality control, dimension reducing, clustering and marker gene detection were used to depict cell subclusters. Differential gene expression analysis and functional enrichment were utilized to demonstrate cell cluster functions and their changes under UAC. Pseudo-time analysis was applied for cell development trajectory, while cell communication prediction was used to show alternations in the interaction among cell clusters. RESULTS: There were 9 cell clusters in rat condyle, containing osteochondral cells and bone marrow immune cells. Under UAC, the number of osteochondrocytes decreased whereas immune cells accumulated. Condyle cartilage and bone tissue contained 6 functional groups of cells. Among them, D and F group maintained progenitor characteristics and possessed the ability to develop into other groups. In UAC condition, osteochondrocytes witnessed impaired extracellular matrix organization, activated senescent or inflammatory pathways, and diminished cell-cell interaction. Meanwhile, in the bone marrow, neutrophils showed enhanced chemotaxis and degranulation, mononuclear-phagocytes displayed increased phagosomes, activated B cells were also recruited. CONCLUSIONS: There are progenitor cells in condyle cartilage and bone tissue, whose function impaired under UAC. At the same time, immune cells in the bone marrow are activated. Targeted modulation of osteochondral progenitors and immune cells could contribute in alleviation the condyle tissue damage in TMJOA.
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    Effect of fiberoptic bronchoscope guided nasotracheal intubation on epistaxis after trachea extubation
    CAO Shuang, KANG Hua, CHEN Jie
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 253-257.   DOI: 10.19438/j.cjoms.2023.03.008
    Abstract186)      PDF (852KB)(39)      
    PURPOSE: To explore the influence of fiberbronchoscopic guidance on the incidence and severity of epistaxis during extubation among patients with nasotracheal intubation (NTI). METHODS: This retrospective analysis was conducted among patients who received general anesthesia with NTI and extubated in the postanesthesia care unit between October 2021 to October 2022. According to different intubation approach, the patients were divided into fiberoptic bronchoscope guided group (fiberoptic group), blind insertion and video laryngoscope group (video laryngoscope group). The propensity score matched analysis (PSM) was used to equalize the baseline data of the two groups, and then the incidence and severity of epistaxis during extubation were compared between the two groups. SPSS 26.0 software package was used for data analysis. RESULTS: There was no significant difference in baseline data between the two groups after PSM(P>0.05). The incidence of epistaxis was higher in the video laryngoscope group (38.8%) than in the fiberoptic group (18.4%; relative risk, 0.475; 95%CI: 0.296-0.762; P<0.001). The severity of bleeding was also lower in the video laryngoscope group (Wilcoxon Mann-Whitney odds, 0.644; 95%CI: 0.490-0.832, P=0.001). CONCLUSIONS: Fiberoptic bronchoscope guided NTI reduced the incidence and severity of epistaxis during extubation when compared with NTI performed via blind insertion and video laryngoscope.
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    Application prospect of tumor treating fields technology in head and neck cancer
    LI Chen-xi, GONG Zhong-cheng, ZHAO Hua-rong, DING Ming-chao, LIU Hui
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 425-431.   DOI: 10.19438/j.cjoms.2023.05.001
    Abstract182)      PDF (1218KB)(71)      
    In recent years, major breakthroughs have been made in the treatment of malignant tumours with research and development progress of immunologic agents and molecular targeted drugs, but it is still the main cause of global disease death. Tumour treating fields (TTFields) is a new non-invasive approach to cancer treatment. TTFields can provide a kind of low-intensity (1-3 V/cm), intermediate frequency (100-300 kHz) alternating electric fields delivered locally to the tumour, which can destroy the chromosome segregation of mitotic tumour cells and induce dielectrophoresis to arise cell structure disturbance and apoptosis. The sensitive parameters of TTFields for normal and cancerous cells are different, but TTFields has no effect on quiescent cells. Hence, it has the advantages of fewer side effects and less trauma, and has great potential. Additionally, its efficacy and safety have been verified in phase III clinical trials of glioblastoma multiforme. Some clinical trials on TTFields have also been carried out in other kinds of solid tumours. This article reviewed the latest research progress of TTFields, expounding its micromechanism and discussing its application prospects in head and neck cancer.
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    Retrospective analysis of 190 cases of oral and maxillofacial space infection complicated with hyperglycemia
    YANG Zuo-yi, YE Lei, ZHENG Ling-yan, CHEN Chang-yu, FU Jia-yao
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 360-365.   DOI: 10.19438/j.cjoms.2023.04.007
    Abstract172)      PDF (684KB)(105)      
    PURPOSE: To analyze the difference between oral and maxillofacial space infection(OMSI) patients with diabetes mellitus, stress hyperglycemia and normal blood glucose in general data, clinical manifestations, laboratory test, and dominant bacterial flora of infection. METHODS: A retrospective study was conducted in 190 patients diagnosed with oral and maxillofacial infection and treated at the Department of Oral Surgery, Shanghai Ninth People's Hospital from August 2020 to June 2022. Statistical analysis of general data, clinical manifestations, laboratory test, and dominant bacterial flora of infection between the three groups was performed with SPSS 25.0 software package. RESULTS: Between diabetic group and stress hyperglycemia group, absolute number of lymphocytes, sodium and chlorine differed significantly; between diabetic group and normal blood glucose group, age, neutrophil absolute number, neutrophil percentage, lymphocyte percentage, C-reactive protein, IL-6, IL-8, tumor necrosis factor-α, procalcitonin, urea, serum uric acid, fibrinogen, sodium, chlorine and total carbon dioxide differed significantly; between stress hyperglycemia group and normal glycemia group,the percentage of neutrophil, percentage of lymphocyte, absolute number of lymphocyte, C-reactive protein, IL-8, tumor necrosis factor-α, and urea differed significantly. CONCLUSIONS: The clinical features and laboratory results of OMSI patients with diabetes, stress hyperglycemia and normal blood glucose are significantly different, suggesting that the three groups of patients should be distinguished in clinical diagnosis and treatment, and more targeted treatment should be provided.
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    Effect of alveolar fossa preservation with different implant materials on alveolar ridge resorption in patients undergoing posterior tooth extraction
    ZHU Min-yan, WANG Hai-yan, YUAN Yin-yin
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 403-406.   DOI: 10.19438/j.cjoms.2023.04.014
    Abstract158)      PDF (497KB)(89)      
    PURPOSE: To investigate the effect of alveolar preservation with different implant materials on alveolar ridge absorption in patients with posterior tooth extraction. METHODS: Eighty-six patients with tooth restoration after extraction admitted to Zhejiang Greentown Cardiovascular Hospital from March 2016 to April 2020 were selected. The patients were divided into experimental group and control group according to the random number, 43 cases in each group. After tooth extraction, patients in the experimental group implanted platelet-rich fibrin(PRF) into the alveolar fossa, while patients in the control group implanted collagen plugs into the alveolar fossa after tooth extraction. The time of wound healing, the height of alveolar soft tissue and the width of alveolar ridge were observed immediately and 6 months after surgery. SPSS 23.0 software package was used for data analysis. RESULTS: The postoperative wound healing time was (10.52±3.14) d in the experimental group, which was significantly shorter than (17.68±5.35) d in the control group(P<0.05). The alveolar soft tissue height of the experimental group was significantly lower than that of the control group 6 months after operation(P<0.05), but there was no significant difference between the mesial papilla and distal papilla (P>0.05). The experimental group was significantly higher than the control group in alveolar ridge widths at 20% and 70% of the root length 6 months postoperatively (P<0.05), but there was no significant difference between the two groups at 50% of the root length (P>0.05). CONCLUSIONS: Compared with collagen plug, the application of PRF in the preservation of extraction site can promote wound healing time and reduce absorption of alveolar ridge. It is an ideal filling and covering material for the preservation of extraction site at present.
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    Multiple calcified epithelioma: a case report and gene analysis
    SONG Jiao-jiao, LU Qian, CAO Zhang, ZUO Jin-hua, WANG Wen-long, MA Xiang-rui, WANG Li
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 526-528.   DOI: 10.19438/j.cjoms.2023.05.018
    Abstract156)      PDF (879KB)(35)      
    Calcified epithelioma (CE), also known as pilomatricoma (PM), is an ectodermal benign tumor originating from the outer root sheath cells of hair follicles. Generally, it only occurs in the upper limb trunk and face and neck, and multiple calcified epithelioma is even rarer in clinic. This paper reported a case of multiple calcified epithelioma and carries out related gene detection, and discussed based on related literature, in order to provide some basis for clinical diagnosis and treatment.
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    Study on risk model for postextraction bleeding of mandibular third molars
    WANG Jian-rong, SUN Jing, ZHAO Shu-hong, SHANG Jiang
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 479-485.   DOI: 10.19438/j.cjoms.2023.05.009
    Abstract148)      PDF (987KB)(98)      
    PURPOSE: To explore the risk factors of bleeding after mandibular third molar extraction and establish a prediction model to provide reference for clinical decision-making. METHODS: Clinical data of 610 cases of mandibular third molar extraction were collected for the study. Association of postextraction bleeding with the patient demographic variables (gender), tooth variables(position, impacted angle) and other variables (periodontitis, intraoperative anesthetic drugs, flap, postoperative treatment, hemostatic materials, patient compliance). SAS 9.4 software package was used to analyze the data. RESULTS: The incidence of postextraction bleeding was 10.33% in 610 patients after mandibular third molars extraction, and 63 patients had postextraction bleeding. Multivariate logistic regression analysis showed that the position, impacted angle, flap, postoperative treatment, patient compliance were independent risk factors for postextraction bleeding of mandibular third molars. The results showed that the prediction model had good differential validity(AUC=0.916), high calibration degree (P=0.605), and certain clinical application value. CONCLUSIONS: The position, impacted angle, flap, postoperative treatment and patient compliance are not only risk factors for postextraction bleeding, but also predictive factors for predictive models.
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    Protein profiling analysis of oral squamous cancer derived extracellular vesicle subgroups
    WU Ruo-yi, WANG Xiao-ning, ZHAI Pei-song, ZHANG Jian-jun, CHEN Wan-tao
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 326-331.   DOI: 10.19438/j.cjoms.2023.04.002
    Abstract142)      PDF (1063KB)(101)      
    PURPOSE: To reveal the commonality and heterogeneity in protein contents of extracellular vesicles (EVs) subgroups obtained by different immunomarkers, and provide data support for researchers to select appropriate isolation protocols. METHODS: In this study, oral cancer cells CAL27, pancreatic cancer cells PANC-1 and gastric cancer cells AGS were used, and EVs derived from them were isolated by 4 EVs markers CD9, CD63, CD81 and EpCAM. Then the proteins from these 4 different EVs subgroups were detected by mass spectrometry. The commonality and heterogeneity between EVs subgroups were evaluated by funrich3.1.3 software. SPSS 19.0 software package was used for statistical analysis. RESULTS: Under the same culture conditions, AGS cells produced the highest number of EVs, followed by CAL27 cells and the least by PANC-1 cells. Among the 4 different EVs isolation methods, the EpCAM marker-based isolation method was the most efficacious. The results of principal component analysis showed that the subgroups of EVs involved in this study were heterogeneous at the level of cell origin as well as at the level of isolation markers. The results of the cellular component analysis of the protein profile showed that 86.11% of the proteins enriched by CD63+ EVs derived from CAL27 were related to exosomes, which was significantly higher than the percentage of the CD9+, CD81+ and EpCAM+ EVs subgroups(70.92%, 70.90% and 63.68%); while 37.96% of the enriched proteins in the CD63+ EVs subgroup were related with cell membrane, which was lower than the percentage of CD9+, CD81+, and EpCAM+ EVs subgroups (53.20%, 61.19% and 49.53%), indicating that EVs subgroups isolated by different immunomarkers had different origins. CONCLUSIONS: The subgroups of EVs involved in this study are heterogeneous at the cellular origin level and at the immunomarker level. Among them, CD63+ EVs may originate more from the endosomal pathway, while CD9+, CD81+ and EpCAM+ EVs originate more from the plasma membrane outgrowth pathway. The EVs subgroups obtained based on different isolation markers were differential in terms of cell biological functions.
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    Tongue squamous cell carcinoma, oropharyngeal carcinoma and gingival carcinoma secondary to nasopharyngeal carcinoma: a case report and literature review
    WANG Bo, SHEN Yue-hong, YANG Hong-yu
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 301-305.   DOI: 10.19438/j.cjoms.2023.03.016
    Abstract138)      PDF (1054KB)(40)      
    Nasopharyngeal carcinoma (NPC) is a relatively rare disease in the world, with a unique geographical distribution, but high incidence in Southeast Asia. Nasopharyngeal carcinoma is mostly poorly differentiated squamous cell carcinoma (98%) and radiotherapy is the first choice of treatment. Radiotherapy and chemotherapy have been considered to have a duality, which can treat cancer and cause cancer. The probability of radionecrosis of the jaw after radiotherapy for head and neck cancer is 1%-3%, mainly occurring in the mandible. This paper reported a case of left tongue squamous cell carcinoma, left oropharyngeal carcinoma and left lower gingival carcinoma after radiotherapy and chemotherapy for nasopharyngeal carcinoma, and the occurrence of radiation osteomyelitis of the jaw. The history, clinical manifestations, treatment and prognosis of this case were discussed based on reviewing the literature.
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    Current status of maxillary sinus floor augmentation technology
    CHEN Jun, XU Guang-zhou
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 291-300.   DOI: 10.19438/j.cjoms.2023.03.015
    Abstract137)      PDF (843KB)(59)      
    Tooth loss in the maxillary posterior region often leads to the lack of vertical bone mass between the maxillary sinus floor and the alveolar crest in the missing region. Maxillary sinus floor augmentation is the mainstream method to solve vertical bone mass deficiency in the posterior maxillary region. Since the 1960s, from origin to develop until maturity, the research of maxillary sinus floor augmentation has been continuously innovated. This article reviewed the evolution, common complications and management of maxillary sinus floor augmentation, bone grafting, pathological changes and management of maxillary sinus, and the influence of anatomic factors of maxillary sinus on osteogenesis.
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    Accuracy of MRI to measure and evaluate clinical staging of oral squamous cell carcinoma
    SI Cheng-yun, LIU Meng-qiu, WENG Hai-yan, ZHANG Li-yu, AN Xing-fei, ZHOU Yu
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 390-396.   DOI: 10.19438/j.cjoms.2023.04.012
    Abstract136)      PDF (1445KB)(55)      
    PURPOSE: To investigate the accuracy of magnetic resonance imaging (MRI) for measuring and assessing the clinical staging of oral squamous cell carcinoma (OSCC). METHODS: A total of 71 patients with OSCC in The First Affiliated Hospital of University of Science and Technology of China from February 2020 to September 2022 were enrolled. The MRI measurements of maximum tumor diameter(MTD), depth of invasion(DOI), and maximum cut sections were recorded, pathological sections were made on the sections, the pathological MTD and DOI were measured and statistically analyzed, and the cervical lymph node status assessed by MRI was compared with the postoperative pathological lymph node status to analyze the accuracy of preoperative MRI measurements and clinical staging. SPSS 26.0 software package was used for data analysis. RESULTS: The mean DOI measured on the MRI was 2.54 mm(95%CI: 3.56-1.53, P<0.05), higher for Gd-T1WI sequence, with correlation coefficient r=0.984; the mean DOI measured on T2WI sequence was 3.09 mm(95%CI: 4.88-1.29, P<0.05) higher, with correlation coefficient r=0.953. Bland-Altman dot plots showed that the measurements of Gd-T1WI sequence were more consistent with pathological DOI values. At the same time, the clinical measurements of MTD were 0.85 cm (95%CI: 0.78-0.91, P<0.05), higher than the histologic findings, with correlation coefficient r of 0.958; the MRI measurements of MTD were 0.21 cm(95%CI: 0.10-0.32, P<0.05), higher than the histologic findings, with correlation coefficient r of 0.878. The MTD measured by MRI was significantly lower than that measured by clinical visualization. The preoperative assessment of cervical lymph node status by MRI was true-positive in 69.6% and true-negative in 89.6% of patients. CONCLUSIONS: MRI has a high accuracy in measuring clinical stage in patients with OSCC and can be used as a reliable reference method for assessing clinical stage.
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    Diagnosis and treatment of oral soft tissue infection caused by pericoronitis after bone marrow transplantation: a case report
    PANG Chao-yuan, TIAN Wen-yan
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 421-424.   DOI: 10.19438/j.cjoms.2023.04.018
    Abstract128)      PDF (1159KB)(71)      
    Hematopoietic stem cell transplantation(HSCT) is one of the important methods for the treatment of severe aplastic anemia(SAA). Some oral complications will occur during bone marrow transplantation period such as oral ulcer and infections. Prevention and treatment of these oral complications reasonably is the key to the success of bone marrow transplantation. In this paper, we reported the clinical treatment of a patient with oral soft tissue infection caused by pericoronitis after bone marrow transplantation, in order to investigate oral health management of bone marrow transplantation patients and provide some reference to improve the success rate of bone marrow transplantation.
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    Clinical data analysis of 119 supernumerary teeth in posterior teeth area
    LIU Xiao-lin, WANG Ze-chen, REN Qun, LIU Xiao, LIU Wen-jing, FENG Ying, FENG Xiao-wei
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 243-247.   DOI: 10.19438/j.cjoms.2023.03.006
    Abstract119)      PDF (1044KB)(56)      
    PURPOSE: To investigate the clinical characteristics of supernumerary teeth in posterior teeth area. METHODS: The data of 119 supernumerary teeth in the posterior teeth area of 55 patients in Stomatology Hospital of Hebei Medical University from June 2014 to May 2020 were analyzed retrospectively from the aspects of the number, position and shape of supernumerary teeth. SPSS 21.0 software package was used for data analysis. RESULTS: Among 55 patients, there were 34 males and 21 females. Twenty-nine cases(52.73%) had one tooth, followed by 11 cases(20.0%) and 8 cases(14.55%) with two and three teeth respectively. Among the 119 supernumerary teeth, 84.87% were located in the premolar region, 57.98% occurred in the mandible, 78.16% were lingual(palatal), 63.02% had a premolar-like shape, 97.48% were in an unerupted state, and 27.73% had an influence on the surrounding teeth. CONCLUSIONS: Female is more than male in the incidence of supernumerary teeth in posterior teeth area. One tooth is the most common, the lower jaw is more than the upper jaw, the lingual (palatal) side is more than the buccal side, the premolar area is more common, the main shape is premolar-like, and some supernumerary teeth will affect the eruption of the surrounding teeth.
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    Osteogenic role of bone substitute in maxillary sinus augmentation and simultaneous implantation
    WANG He-jing, ZHANG Cai-xin, XUN Xing-xiang, HAN Lin-zi, YAN Ting-ting, XU Xiao, YUAN Rong-tao
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 218-224.   DOI: 10.19438/j.cjoms.2023.03.002
    Abstract118)      PDF (1749KB)(47)      
    PURPOSE: To explore whether it is necessary to implant bone substitute materials for maxillary sinus augmentation and simultaneous implantation, and to compare the osteogenic role of different bone substitutes. METHODS: Twelve New Zealand white rabbits (3-month, male) were used for maxillary sinus augmentation and simultaneous implantation, and 24 maxillary sinuses in 12 rabbits were randomly divided into 4 groups(n=6): blood clot group, blank liposome-hydrogel group, medicine-loaded liposome-hydrogel group, and bone allograft group. At 3 months, all samples were entirely taken and the effects of different bone substitutes on promoting bone regeneration were evaluated by micro-CT, H-E staining, Masson staining, immunohistochemistry (IHC), and H-E staining of bone tissue grinding slices. RESULTS: Micro-CT, H-E staining and Masson staining displayed that there were different degrees of new bone formation around the implants in 4 groups. Compared to blood clot group, more new bone formation was observed in blank liposome-hydrogel group. Compared with blood clot group and blank liposome-hydrogel group, more new bone formation was observed in medicine-loaded liposome-hydrogel group and bone allograft group. Moreover, compared to bone allograft group, more new blood vessels were observed in bone matrix in medicine-loaded liposome-hydrogel group. IHC showed the expression of angiogenesis indexes in medicine-loaded liposome-hydrogel group was highest in 4 groups. The expression of osteogenic indexes in medicine-loaded liposome-hydrogel group and bone allograft group was higher than other groups. H-E staining of bone tissue grinding slices showed that the osseointegration of the implants was good. The medicine-loaded liposome-hydrogel group had more bone surrounding the implants. CONCLUSIONS: Using bone substitute in maxillary sinus augmentation surgery and simultaneous implantation not only maintains the height of maxillary sinus mucosa, but also improves the efficiency of osteogenesis. Compared to bone allograft, medicine-loaded liposome-hydrogel with injectability is more suitable for irregular bone defect by minimally invasive filling. Medicine-loaded liposome-hydrogel effectively promotes angiogenic bone regeneration by steady drug release.
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    Analysis of highly cited papers in Chinese core journals of stomatology from 2016 to 2021
    LI Xue-lu, XU Ling, ZHANG Hui-hong
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 272-278.   DOI: 10.19438/j.cjoms.2023.03.012
    Abstract117)      PDF (1055KB)(68)      
    PURPOSE: To objectively evaluate the distribution characteristics of highly cited papers(HCP) in 19 core journals of stomatology, and to explore the recent research hotspots in stomatology. METHODS: HCPs in 19 core journals of stomatology from January 2016 to December 2021were retrieved from CNKI database. The years, institutions, journals, fund, key words and the citation frequencies of HCPs were recorded. The data were analyzed by bibliometrics methods and SATI was used to draw a co-occurrence knowledge map. RESULTS: A total of 187 highly cited papers was selected. “Chinese Journal of Stomatology” was the journal with the most HCPs and the highest total citations, while “Shanghai Journal of Stomatology” with the highest mean citation counts. The top 10 institutions published 99 HCPs, accounting for 52.94%. The largest number of HCPs had a collaboration among 2 authors. There were 96 papers supported by fund (51.34%) while 91 papers without fund(48.66%). Among the six highest cited papers in the years, 3 were editorials, 2 were consensus and guidelines, and 1 was clinical research. "Chronic periodontitis", "root canal treatment", "CAD/CAM" and "clear aligners" were the most common key words. CONCLUSIONS: There is a mutual relationship between establishing a good journal brand and high-quality papers. The best cooperation scale should be selected for scientific creation. Editorials, consensus and guidelines in stomatology have an obvious advantage in achieving high citations. "Digital stomatology" may be the development trend and frontier in the next few years. The research results have certain guidance value for the construction of journals, manuscript selection and talent training.
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