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Expert consensus on surgical treatment of hemangiomas and vascular malformations in the head and neck WANG Yan-an, QIN Zhong-ping, ZHENG Jia-wei, LI Chun-jie, LIU Shao-hua, YANG Yao-wu, CHEN Gang, CHEN Wei-liang, LIU Xue-jian, DU Zhong, ZHANG Lei, WANG Ye-fei, WANG De-ming, SU Li-xin, XIE Feng, DONG Chang-xian, GUO Lei, LI Kai, GU Song, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 105-117.   DOI: 10.19438/j.cjoms.2024.02.001 Abstract （219）      PDF （2515KB）（270）       Knowledge map    Hemangiomas and vascular malformations are common benign vascular diseases in the head and neck region. The evolution and extensive implementation of non-surgical therapeutic modalities have resulted in considerable improvement or even total remission in a significant number of patients in minimally invasive or non-invasive procedures. Nonetheless, under certain circumstances, surgical treatment remains an irreplaceable treatment modality within the comprehensive treatment sequence for hemangiomas and vascular malformations in the head and neck. However, there is no established standard or consensus in the academic community on how to choose and apply surgical treatment. Therefore, to enhance the treatment efficacy of hemangiomas and vascular malformations amongst domestic peers, and to standardize surgical treatment protocols, this consensus brings together the discussion opinions of relevant experts from many medical schools and affiliated hospitals nationwide. Based on the latest domestic and international research results and diagnosis and treatment experience, we formulated this expert consensus from the aspects of preoperative diagnosis and preparation, surgical treatment indications and strategies, postoperative care and observation, common complications and treatment after surgery, follow-up and social psychological support. It is expected to be used in clinical practice and to guide relevant professional doctors carrying out treatment. Reference | Related Articles | Metrics

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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （637）      PDF （2051KB）（898）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022) ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian China Journal of Oral and Maxillofacial Surgery    2022, 20 (4): 313-319.   DOI: 10.19438/j.cjoms.2022.04.001 Abstract （867）      PDF （1061KB）（725）       Knowledge map    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2013, 11 (1): 39-43.   Abstract （284）      PDF （904KB）（581）       Knowledge map    Related Articles | Metrics

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Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst LIU Bing, HE Yue, PENG Xin, SUN Chang-fu, HAN Zheng-xue, WU Yu-nong, PENG Li-wei, ZHAO Yi, TAO Qian, HAN Xin-guang, LI Jin-song, SU Tong, LI Bo, ZHANG Lei, HU Yan-ping, CHEN Chuan-jun, LI Yi, LI Tie-jun, ZHAO Yi-fang China Journal of Oral and Maxillofacial Surgery    2022, 20 (3): 209-218.   DOI: 10.19438/j.cjoms.2022.03.001 Abstract （1598）      PDF （1176KB）（678）       Knowledge map    Odontogenic keratocyst (OKC) is a common cystic lesion of the jaw. The nomenclature and nature of OKC remain controversial as a result of its local invasive behavior and high tendency of recurrence, which is evidently different from other types of jaw cysts. With the in-depth study of OKC pathogenesis and the advance of treatment concept and surgical techniques, it becomes possible to reduce the rate of postoperative recurrence and simultaneous functional reconstruction of the jaw. To establish standard diagnosis and treatment algorithms or guidelines of OKC, we organized peer experts in China to reach a consensus on pathogenesis, clinical manifestations, imaging characteristics, histopathological features, surgery and postoperative follow-up strategies of OKC for the references of clinicians. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2007, 5 (2): 83-90.   Abstract （1956）      PDF （1354KB）（3993）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2006, 4 (6): 467-470.   Abstract （1880）      PDF （747KB）（1062）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 185-188.   DOI: 10.19438/j.cjoms.2017.02.018 Abstract （359）      PDF （2529KB）（960）       Knowledge map    Reference | Related Articles | Metrics

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Effects and mechanism of quercetin on proliferation and apoptosis of human adenoid cystic carcinoma cell line ACC-M MI Jing, ZHANG Ming-bin, WAN Guang-yong China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 121-126.   DOI: 10.19438/j.cjoms.2017.02.005 Abstract （366）      PDF （3998KB）（484）       Knowledge map    PURPOSE : To observe the effect of quercetin on human adenoid cystic carcinoma cells (ACC-M) proliferation and apoptosis. METHODS : CCK-8 staining was used to detect different concentrations of quercetin on ACC-M cell proliferation inhibition, the inhibition rate and IC50 were calculated; flow cytometry was used to detect ACC-M cell apoptosis rate and cell cycle distribution; Survivin mRNA of ACC-M cells was detected by RT-PCR. The difference between each group was analyzed with SPSS20.0 software package. RESULTS : Quercetin inhibited ACC-M cell growth obviously in a concentration dependent manner. The IC50 was 151.12 μmol/L (P<0.05); annexin V/PI double staining assay showed that quercetin can induce apoptosis of ACC-M cells in a dose and time dependent manner (P<0.05); PI staining assay showed that quercetin played an important role in G2/M cells, which were specifically arrested in G2/M phase. RT-PCR showed the quercetin concentration was negatively related with survivin mRNA in ACC-M cells and 200 μmol/L quercetin could inhibit the expression of Survivin mRNA significantly. CONCLUSION S: Quercetin can inhibit the proliferation of ACC-M cells and induce its apoptosis in a time and dose dependent manner by down-regulating the level of Survivin. Reference | Related Articles | Metrics

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Research progress of the effect of osteoporosis on dental implant restoration JIN Xia-yue, GU Yin-xin China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 81-86.   DOI: 10.19438/j.cjoms.2023.01.014 Abstract （197）      PDF （700KB）（222）       Knowledge map    Osteoporosis is a systemic bone metabolism disease that occurs in middle-aged and elderly people. The incidence of osteoporosis is increasing year by year with the increase of the elderly population. Meanwhile, with the progress of dental implant technology, more and more elderly people undergo implant restoration. Osteoporosis was once considered to be one of the risk factors for dental implant restoration, which may influence the initial stability and survival rate of implants, and drugs for osteoporosis treatment also inevitably affect the osseointegration of implants. This article reviewed relevant studies to summarize the impact of osteoporosis on dental implant restoration. Reference | Related Articles | Metrics

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Interpretation of the new TNM classification and the NCCN guidelines for cancers of the oral cavity and oropharynx SHANG Wei, ZHENG Jia-wei China Journal of Oral and Maxillofacial Surgery    2018, 16 (6): 533-546.   DOI: 10.19438/j.cjoms.2018.06.010 Abstract （1764）      PDF （9751KB）（507）       Knowledge map    The AJCC Cancer Staging Manual and the NCCN Clinical Practice Guidelines in Oncology are widely used in clinical practice. NCCN diagnosis and treatment guidelines are closely related to TNM staging, and the guidelines provide more detailed diagnostic and therapeutic criteria for cancers with different TNM staging as a basis for guiding clinical application. The 8th edition TNM staging system for cancers of the oral cavity and oropharynx introduced a number of significant changes, such as depth of invasion(DOI), extranodal extension (ENE), human papillomavirus(HPV) and other indicators were used in the new stage, and a new chapter describing the staging of HPV-associated oropharyngeal cancers had been added. The 2018 NCCN guidelines for cancers of the oral cavity and oropharynx timely reflected the new changes in the 8th edition TNM staging, and the panel also created separate algorithms for HPV-associated (p16-positive) oropharyngeal cancer. The new TNM staging and NCCN guidelines are of great guiding significance in the treatment strategies and plans for patients with cancers of the oral cavity and oropharynx. The treatment recommendations were provided and the interpretation was made for the needs of clinical practice in this paper. Reference | Related Articles | Metrics

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Familial gigantiform cementoma: analysis of a large Chinese pedigree WANG Hong-wei, YU Miao, QIN Xing-jun, WANG Li-zhen, XU Li-qun, ZHANG Chen-ping China Journal of Oral and Maxillofacial Surgery    2014, 12 (4): 360-364.   Abstract （458）   HTML （2）    PDF （1571KB）（1076）       Knowledge map    PURPOSE: Familial gigantiform cementoma (FGC) is a rare autosomal dominant benign odontogenic tumor. The purpose of this study is to describe the clinical characteristics of FGC in a Chinese family with multiple-affected members. METHODS: Detail screening was conducted on family members of a 13-year-old Chinese male with recent diagnosis of FGC. All family members of the patient were interviewed. Demographic, past medical and surgical histories were collected from family members with history of FGC diagnosis. Clinical information related to the lesions (symptom, age of onset, history of treatment, histological and radiological findings) was obtained. Literature review was also presented in this study. RESULTS: In this study, we found a four-generation Han Chinese family with thirteen affected members with diagnosis of FGC. Eight male patients and five female patients were appreciated in the study. All 13 patients experienced the onset of symptoms at 11-13 years old followed by a rapid and expansive growth phrase at the age of 14-16, and growth suppression phase around age 18 to 20 years old. Eight patients in our series had sustained multiple pathological long bone fractures (average 3-4 x/person) between the age of 13 and 16 years. CONCLUSIONS: The familial history of this case helps to demonstrate that the inheritance pattern of FGC was autosomal dominant. FGC usually presented with three distinctive growth phrases: ①Initial onset; ②Rapid expansion; ③Growth suppression phase. Reference | Related Articles | Metrics

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Synthesis of carbon dots with dual roles of osteogenic and antibacterial effects for infected bone defects treatment LIU Yi-ge, WANG Zi-lin, GUO Zhi-yong, WU Hao, WANG Wen-ying, HAN Jing, LIU Jian-nan, ZHANG Chen-ping China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 11-18.   DOI: 10.19438/j.cjoms.2023.01.002 Abstract （212）      PDF （2337KB）（188）       Knowledge map    PURPOSE: To investigate the effects of a new kind of carbon dots (CDots) made from gentamicin and folic acid on osteogenic differentiation and autophagy of rat bone marrow stromal cells (BMSCs), as well as the inhibition of common oral pathogenic bacteria. METHODS: CDots were prepared by hydrothermal method using gentamicin and folic acid as raw materials, and characterized by transmission electron microscopy and UV spectrophotometer. Biocompatibility was evaluated by CCK-8 assay and apoptosis assay, and uptake by cells was observed by laser confocal microscopy. Alkaline phosphatase staining and alizarin red staining were used to detect the effect on osteogenic differentiation of BMSCs. Real-time quantitative PCR was performed to detect the mRNA expression levels of osteogenic and autophagy-related genes. Scanning electron microscopy and plate colony assay were performed to observe the ability of CDots to inhibit Porphyromonas gingivalis and Fusobacterium nucleatum. Graph Pad Prism 9 software was used for statistical analysis. RESULTS: The CDots solution emitted blue fluorescence under UV light irradiation with a UV absorption peak at 330 nm; the PL emission peak of CDots was concentrated at 440 nm under the excitation of 405 nm laser. Transmission electron microscopy showed that the average diameter of CDots was about 12 nm. CCK-8 assay and apoptosis assay showed that CDots were biocompatible. Laser confocal microscopy results showed that CDots could be taken up by BMSCs. The results of alkaline phosphatase staining and alizarin red staining showed that CDots increased staining. mRNA expression of the osteogenic genes OPN, OCN, BMP-2, and autophagy-related genes LC3, Beclin1, ATG-12 was increased by CDots compared to the control group(P<0.05). In vitro antibacterial assays indicated that CDots could inhibit the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. CONCLUSIONS: CDots prepared with gentamicin and folic acid are biocompatible, have dual osteogenic and antibacterial effects, promote osteogenic differentiation of BMSCs, promote elevated autophagy levels, and have inhibitory effects on the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. Reference | Related Articles | Metrics

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Expert consensus on clinical diagnosis and treatment for Chinese oral mucosal melanoma GUO Wei, REN Guo-xin, SUN Mo-yi, KONG Yun-yi, WANG Li-zhen, BU Rong-fa, RAN Wei, TANG Zhan-gui, LI Long-jiang, MENG Jian, SUN Zhi-jun, SHANG Wei, LV Jiong, WU He-ming, ZHANG Chen-ping, HE Yue, MA Xu-hui, SONG Hao, JU Hou-yu, ZHENG Jia-wei, GONG Zhong-cheng, YANG Kai, ZHANG Jie, WU Yun-teng China Journal of Oral and Maxillofacial Surgery    2021, 19 (6): 481-488.   DOI: 10.19438/j.cjoms.2021.06.001 Abstract （540）      PDF （1408KB）（535）       Knowledge map    [Summary] Head and neck mucosal melanoma (HNMM) is a kind of highly malignant solid tumor. The 5-year survival rate of HNMM is about 20% for a long time. Its pathogenic factors, driving genes, clinical manifestations and treatment methods are quite different from skin melanoma. In 2015, the first Chinese expert consensus on the diagnosis and treatment of head and neck mucosal malignant melanoma was established. After more than six years of application, the clinical diagnosis and treatment of HNMM has been greatly improved. With the deepening of clinical and basic research on mucosal melanoma, the diagnosis, treatment and prognosis of HNMM have changed greatly in recent years, especially with the vigorous development of various branches of head and neck. Oral, nasal, sinus, eye and other mucosal melanoma have developed their own unique diagnosis and treatment model. This consensus can’t meet the actual needs of the current clinical practice. In this regard, the expert group believes that head and neck mucosa contains a wide range of anatomy, involving more clinical departments, and the diagnosis and treatment mode of melanoma varies significantly between different disciplines. It is urgent to meet the clinical consensus of more specialized diagnosis and treatment of individualized treatment and precise treatment. In order to further improve the long-term survival rate and quality of life of oral mucosal melanoma (OMM) and make the consensus to better guide clinical work, this expert group will focus on OMM and conduct in-depth discussion, and establish expert consensus based on evidence-based medicine and empirical medicine. Considering the individual differences of patients, this consensus can be used as a reference for clinical practice of OMM. Reference | Related Articles | Metrics

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Current research progress of physiological functions of Foxc2 SHEN Hong-zhou, SI Jia-wen, SHEN Guo-fang China Journal of Oral and Maxillofacial Surgery    2018, 16 (2): 188-192.   DOI: 10.19438/j.cjoms.2018.02.019 Abstract （516）      PDF （4019KB）（544）       Knowledge map    Foxc2, one of the family members of the evolutionarily highly conserved Forkhead transcription factors, possesses a classical Forkhead domain. Foxc2 has been shown to be involved in various physiological processes including embryonic development, epithelial-to-mesenchymal transition, differentiation of mesenchymal tissue and adipocyte metabolism. Mutations or abnormal regulation of Foxc2 gene could lead to a series of changes, such as developmental disorders of lymphatic system and axial bones, tumorgenesis, aberrant energetic metabolism, and etc. Thus, it seems that thorough research about Foxc2 might further unveil the pathogenesis and developmental mechanism of Foxc2-related diseases. This review mainly focused on the current research findings of physiological functions of Foxc2. Reference | Related Articles | Metrics

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The bur broken into soft palate during tooth extraction: a case report and literature review GUO Lei, LEI Rong-chang, QU Bin-bin, GUO Ge, CHAI An, LUO Ying China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 202-205.   DOI: 10.19438/j.cjoms.2024.02.016 Abstract （53）      PDF （986KB）（60）       Knowledge map    When high-speed dental handpiece combined with surgical cutting bur are used to remove impacted teeth, instrument separation is rare, and bur breaking into the soft palate is even rarer. This paper reported a rare case in which the bur broke into the soft palate during tooth extraction and was successfully removed under local anesthesia with the help of imaging and 3D visualization techniques. Combined with literature review, this paper discussed the causes of this complication and corresponding treatment methods, and explored how to reduce the occurrence of this complication. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2007, 5 (6): 465-468.   Abstract （464）      PDF （840KB）（1166）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2009, 7 (2): 168-175.   Abstract （513）      PDF （1607KB）（1740）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2010, 8 (2): 98-106.   Abstract （988）      PDF （1489KB）（7132）       Knowledge map    Related Articles | Metrics

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Chinese expert consensus on standardized operation process of autotransplantation of teeth Professional Committee of Teeth and Alveolar Surgery, Chinese Stomatological Association China Journal of Oral and Maxillofacial Surgery    2020, 18 (5): 390-394.   DOI: 10.19438/j.cjoms.2020.05.002 Abstract （855）      PDF （4112KB）（871）       Knowledge map    Autotransplantation of teeth refers to the surgical procedure of transplanting tooth from one position to another within the same individuals. This procedure usually involves transferring an impacted, embedded, dislocated or ectopically erupted tooth to an extraction site or a surgically prepared alveolar socket. As one of the most biocompatible oral rehabilitation approach, tooth autotransplantation can preserve alveolar bone volume, restore functioning periodontal tissue and its proprioception, and consequently achieve the purpose of 'turning waste into wealth'. At present, there hasn't been a universally accepted standardized operation process on tooth autotransplantation including its indications, contraindications, preoperative preparation, surgical steps, and postoperative treatment and orders. In order to standardize its clinical application to further increase success rate, in combination with Chinese experts' clinical experience, a consensus on standardized operation process of autotransplantation of teeth has been proposed in this article. Reference | Related Articles | Metrics