Current research progress of physiological functions of Foxc2

doi:10.19438/j.cjoms.2018.02.019

Abstract

Abstract: Foxc2, one of the family members of the evolutionarily highly conserved Forkhead transcription factors, possesses a classical Forkhead domain. Foxc2 has been shown to be involved in various physiological processes including embryonic development, epithelial-to-mesenchymal transition, differentiation of mesenchymal tissue and adipocyte metabolism. Mutations or abnormal regulation of Foxc2 gene could lead to a series of changes, such as developmental disorders of lymphatic system and axial bones, tumorgenesis, aberrant energetic metabolism, and etc. Thus, it seems that thorough research about Foxc2 might further unveil the pathogenesis and developmental mechanism of Foxc2-related diseases. This review mainly focused on the current research findings of physiological functions of Foxc2.

Key words: Foxc2, Physiological function, Mesenchymal tissue

CLC Number:

SHEN Hong-zhou, SI Jia-wen, SHEN Guo-fang. Current research progress of physiological functions of Foxc2[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(2): 188-192.

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