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    Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw
    HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan
    China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001
    Abstract637)      PDF (2051KB)(898)      
    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references.
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    China Journal of Oral and Maxillofacial Surgery    2007, 5 (2): 83-90.  
    Abstract1956)      PDF (1354KB)(3993)      
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    Clinical application of Tent-Peg technique in the reparation and regeneration of alveolar bone-standard operational practice
    ZOU Duo-hong, LIU Chang-kui, XUE Yang, HU Kai-jin, YANG Chi, ZHNAG Zhi-yuan
    China Journal of Oral and Maxillofacial Surgery    2021, 19 (1): 1-5.   DOI: 10.19438/j.cjoms.2021.01.001
    Abstract2052)      PDF (3998KB)(1374)      
    ] Alveolar bone is the foundation of dentology. The reparation and regeneration of alveolar bone defects have strong relationship with sub-disciplines including implant dentistry, orthodontics, periodontology and prosthodontics. Therefore, the effective methods of repairing and reconstructing alveolar bone have important clinical significance and great social benefits. With the development of guide bone regeneration (GBR) technique and advent of alveolar bone regeneration based on stability centered concept, an entirely new bone augmentation approach based on Tent-Peg technique developed rapidly and was validated in clinical practices. The technique is characterized by low technique sensitivity, simple operation procedure, short operation time and low costs. Furthermore, alveolar bone regeneration based on this technique can be achieved with just artificial biomaterials instead of autogenous bone grafts. In conjunction with its advantages, Tent-Peg technique is increasingly favored and valued by patients and clinicians. However, clinicians still face many difficulties achieving effectively clinical application of this technique, including standard operation practice, right position of the Tent-Peg, proper orientation of the pegs and right order of placing GBR membrane and Tent-Peg. Our team established standard operation practice of Tent-Peg technique for alveolar bone regeneration based on clinical practice. We hope that this article will provide a reference and basis for clinicians when applying this technique for alveolar bone regeneration, popularize the clinical application of this technique and finally offer practical help to patients suffering from alveolar bone defects.
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    Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022)
    ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian
    China Journal of Oral and Maxillofacial Surgery    2022, 20 (4): 313-319.   DOI: 10.19438/j.cjoms.2022.04.001
    Abstract867)      PDF (1061KB)(725)      
    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable.
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    China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 185-188.   DOI: 10.19438/j.cjoms.2017.02.018
    Abstract359)      PDF (2529KB)(960)      
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    China Journal of Oral and Maxillofacial Surgery    2006, 4 (6): 467-470.  
    Abstract1880)      PDF (747KB)(1062)      
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    China Journal of Oral and Maxillofacial Surgery    2012, 10 (6): 516-521.  
    Abstract507)      PDF (783KB)(1375)      
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    China Journal of Oral and Maxillofacial Surgery    2009, 7 (2): 168-175.  
    Abstract513)      PDF (1607KB)(1740)      
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    Familial gigantiform cementoma: analysis of a large Chinese pedigree
    WANG Hong-wei, YU Miao, QIN Xing-jun, WANG Li-zhen, XU Li-qun, ZHANG Chen-ping
    China Journal of Oral and Maxillofacial Surgery    2014, 12 (4): 360-364.  
    Abstract458)   HTML2)    PDF (1571KB)(1076)      
    PURPOSE: Familial gigantiform cementoma (FGC) is a rare autosomal dominant benign odontogenic tumor. The purpose of this study is to describe the clinical characteristics of FGC in a Chinese family with multiple-affected members. METHODS: Detail screening was conducted on family members of a 13-year-old Chinese male with recent diagnosis of FGC. All family members of the patient were interviewed. Demographic, past medical and surgical histories were collected from family members with history of FGC diagnosis. Clinical information related to the lesions (symptom, age of onset, history of treatment, histological and radiological findings) was obtained. Literature review was also presented in this study. RESULTS: In this study, we found a four-generation Han Chinese family with thirteen affected members with diagnosis of FGC. Eight male patients and five female patients were appreciated in the study. All 13 patients experienced the onset of symptoms at 11-13 years old followed by a rapid and expansive growth phrase at the age of 14-16, and growth suppression phase around age 18 to 20 years old. Eight patients in our series had sustained multiple pathological long bone fractures (average 3-4 x/person) between the age of 13 and 16 years. CONCLUSIONS: The familial history of this case helps to demonstrate that the inheritance pattern of FGC was autosomal dominant. FGC usually presented with three distinctive growth phrases: ①Initial onset; ②Rapid expansion; ③Growth suppression phase.
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    Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst
    LIU Bing, HE Yue, PENG Xin, SUN Chang-fu, HAN Zheng-xue, WU Yu-nong, PENG Li-wei, ZHAO Yi, TAO Qian, HAN Xin-guang, LI Jin-song, SU Tong, LI Bo, ZHANG Lei, HU Yan-ping, CHEN Chuan-jun, LI Yi, LI Tie-jun, ZHAO Yi-fang
    China Journal of Oral and Maxillofacial Surgery    2022, 20 (3): 209-218.   DOI: 10.19438/j.cjoms.2022.03.001
    Abstract1598)      PDF (1176KB)(678)      
    Odontogenic keratocyst (OKC) is a common cystic lesion of the jaw. The nomenclature and nature of OKC remain controversial as a result of its local invasive behavior and high tendency of recurrence, which is evidently different from other types of jaw cysts. With the in-depth study of OKC pathogenesis and the advance of treatment concept and surgical techniques, it becomes possible to reduce the rate of postoperative recurrence and simultaneous functional reconstruction of the jaw. To establish standard diagnosis and treatment algorithms or guidelines of OKC, we organized peer experts in China to reach a consensus on pathogenesis, clinical manifestations, imaging characteristics, histopathological features, surgery and postoperative follow-up strategies of OKC for the references of clinicians.
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    Expert consensus on surgical treatment of hemangiomas and vascular malformations in the head and neck
    WANG Yan-an, QIN Zhong-ping, ZHENG Jia-wei, LI Chun-jie, LIU Shao-hua, YANG Yao-wu, CHEN Gang, CHEN Wei-liang, LIU Xue-jian, DU Zhong, ZHANG Lei, WANG Ye-fei, WANG De-ming, SU Li-xin, XIE Feng, DONG Chang-xian, GUO Lei, LI Kai, GU Song, HE Yue, ZHANG Zhi-yuan
    China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 105-117.   DOI: 10.19438/j.cjoms.2024.02.001
    Abstract219)      PDF (2515KB)(270)      
    Hemangiomas and vascular malformations are common benign vascular diseases in the head and neck region. The evolution and extensive implementation of non-surgical therapeutic modalities have resulted in considerable improvement or even total remission in a significant number of patients in minimally invasive or non-invasive procedures. Nonetheless, under certain circumstances, surgical treatment remains an irreplaceable treatment modality within the comprehensive treatment sequence for hemangiomas and vascular malformations in the head and neck. However, there is no established standard or consensus in the academic community on how to choose and apply surgical treatment. Therefore, to enhance the treatment efficacy of hemangiomas and vascular malformations amongst domestic peers, and to standardize surgical treatment protocols, this consensus brings together the discussion opinions of relevant experts from many medical schools and affiliated hospitals nationwide. Based on the latest domestic and international research results and diagnosis and treatment experience, we formulated this expert consensus from the aspects of preoperative diagnosis and preparation, surgical treatment indications and strategies, postoperative care and observation, common complications and treatment after surgery, follow-up and social psychological support. It is expected to be used in clinical practice and to guide relevant professional doctors carrying out treatment.
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    China Journal of Oral and Maxillofacial Surgery    2005, 3 (1): 3-9.  
    Abstract1736)      PDF (611KB)(1850)      
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    China Journal of Oral and Maxillofacial Surgery    2007, 5 (4): 243-248.  
    Abstract1465)      PDF (852KB)(1161)      
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    China Journal of Oral and Maxillofacial Surgery    2010, 8 (2): 123-129.  
    Abstract778)      PDF (1218KB)(616)      
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    Overview of current pharmacotherapy for infantile hemangiomas
    ZHENG Jia-wei, MA Kun-ning, ZHANG Ling
    China Journal of Oral and Maxillofacial Surgery    2014, 12 (1): 1-6.  
    Abstract511)   HTML3)    PDF (893KB)(725)      
    Infantile hemangiomas (IH) are the most common tumors of infancy and childhood. 60% of them are localized in the head and neck region. They may impinge on vital structures, ulcerate, bleed, cause high-output cardiac failure or significant disfigurement if left untreated. The traditional treatment methods include drug therapy, laser therapy and surgery, with drug therapy being the mainstay of treatment. The medications most commonly used to treat IH are corticosteroids, beta-adrenergic blocker, pingyangmycin, interferon alfa, imiquimod, and etc. For function- and life-threatening infantile hemangioma, some anti-cancer agents like vincristine may be used as an effective alternative option. This succinct review summarized current pharmacotherapeutic therpy of IH, especially the properties and effectiveness of various beta-adrenergic antagonists in the management of IH.
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    China Journal of Oral and Maxillofacial Surgery    2010, 8 (6): 521-524.  
    Abstract367)      PDF (726KB)(597)      
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    China Journal of Oral and Maxillofacial Surgery    2007, 5 (3): 188-194.  
    Abstract811)      PDF (1128KB)(848)      
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    China Journal of Oral and Maxillofacial Surgery    2010, 8 (2): 98-106.  
    Abstract988)      PDF (1489KB)(7132)      
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    Establishment of human vascular endothelial hypoxia/reoxygeneration injury cell model
    NIU Qi-fang, LI De-long, YANG Yang, QIN Li-zheng, FENG Zhi-en, LI Jin-zhong, HAN Zheng-xue
    China Journal of Oral and Maxillofacial Surgery    2019, 17 (4): 295-299.   DOI: 10.19438/j.cjoms.2019.04.002
    Abstract694)      PDF (4116KB)(726)      
    PURPOSE: To establish a cell model of human vascular endothelial hypoxia/reoxygenation injury, as an in vitro model of tissue flap ischemia-reperfusion injury (IRI). Methods: Primary human umbilical vein endothelial cells (HUVECs) were cultured to the 5th generation, then divided into 4 groups randomly according to the time of exposing in hypoxia condition as 3h/2h group, 6h/2h group, 9h/2h group and control group. The cells of hypoxia groups were placed in low-glucose and serum-free DMEM and submitted to hypoxia condition for 3, 6 and 9 h respectively,then cultured in normoxia condition with original complete medium for 2 h as reoxygenation. After reoxygenation, morphological features, structures and numbers were observed, the rate of surviving cells was determined by Trypan blue assay, and the cell viability was measured by CCK-8 assay, the rate of apoptotic cells was detected by flow cytometry with Annexin V-PI assay. The data were analyzed with SPSS 19.0 software package. Results: Compared with the control group,the morphology of HUVECs were obviously damaged in HRI groups,with increasing time of hypoxia,the damage of cells gradually aggravated. In Trypan blue and CCK - 8 assays, the rate of surviving cells and the cell viability decreased in HRI groups, with the increase of hypoxia time, the rate of surviving cells and the cell viability decreased significantly (P<0.05). Annexin V-PI assay showed that the early and late apoptotic rate of cells in HRI groups were significantly higher compared with the control group; and with the increase of hypoxia time,the early and late apoptotic rate increased gradually(P<0.05). Conclusions: The reliable cell model of human vascular endothelial hypoxia/reoxygenation injury was established successfully with cultured HUVECs, which provides a basis for in vitro studies of tissue flap ischemia-reperfusion injury.
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    Expert consensus on clinical diagnosis and treatment for Chinese oral mucosal melanoma
    GUO Wei, REN Guo-xin, SUN Mo-yi, KONG Yun-yi, WANG Li-zhen, BU Rong-fa, RAN Wei, TANG Zhan-gui, LI Long-jiang, MENG Jian, SUN Zhi-jun, SHANG Wei, LV Jiong, WU He-ming, ZHANG Chen-ping, HE Yue, MA Xu-hui, SONG Hao, JU Hou-yu, ZHENG Jia-wei, GONG Zhong-cheng, YANG Kai, ZHANG Jie, WU Yun-teng
    China Journal of Oral and Maxillofacial Surgery    2021, 19 (6): 481-488.   DOI: 10.19438/j.cjoms.2021.06.001
    Abstract540)      PDF (1408KB)(535)      
    [Summary] Head and neck mucosal melanoma (HNMM) is a kind of highly malignant solid tumor. The 5-year survival rate of HNMM is about 20% for a long time. Its pathogenic factors, driving genes, clinical manifestations and treatment methods are quite different from skin melanoma. In 2015, the first Chinese expert consensus on the diagnosis and treatment of head and neck mucosal malignant melanoma was established. After more than six years of application, the clinical diagnosis and treatment of HNMM has been greatly improved. With the deepening of clinical and basic research on mucosal melanoma, the diagnosis, treatment and prognosis of HNMM have changed greatly in recent years, especially with the vigorous development of various branches of head and neck. Oral, nasal, sinus, eye and other mucosal melanoma have developed their own unique diagnosis and treatment model. This consensus can’t meet the actual needs of the current clinical practice. In this regard, the expert group believes that head and neck mucosa contains a wide range of anatomy, involving more clinical departments, and the diagnosis and treatment mode of melanoma varies significantly between different disciplines. It is urgent to meet the clinical consensus of more specialized diagnosis and treatment of individualized treatment and precise treatment. In order to further improve the long-term survival rate and quality of life of oral mucosal melanoma (OMM) and make the consensus to better guide clinical work, this expert group will focus on OMM and conduct in-depth discussion, and establish expert consensus based on evidence-based medicine and empirical medicine. Considering the individual differences of patients, this consensus can be used as a reference for clinical practice of OMM.
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