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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （636）      PDF （2051KB）（898）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022) ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian China Journal of Oral and Maxillofacial Surgery    2022, 20 (4): 313-319.   DOI: 10.19438/j.cjoms.2022.04.001 Abstract （867）      PDF （1061KB）（725）       Knowledge map    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable. Reference | Related Articles | Metrics

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Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst LIU Bing, HE Yue, PENG Xin, SUN Chang-fu, HAN Zheng-xue, WU Yu-nong, PENG Li-wei, ZHAO Yi, TAO Qian, HAN Xin-guang, LI Jin-song, SU Tong, LI Bo, ZHANG Lei, HU Yan-ping, CHEN Chuan-jun, LI Yi, LI Tie-jun, ZHAO Yi-fang China Journal of Oral and Maxillofacial Surgery    2022, 20 (3): 209-218.   DOI: 10.19438/j.cjoms.2022.03.001 Abstract （1597）      PDF （1176KB）（678）       Knowledge map    Odontogenic keratocyst (OKC) is a common cystic lesion of the jaw. The nomenclature and nature of OKC remain controversial as a result of its local invasive behavior and high tendency of recurrence, which is evidently different from other types of jaw cysts. With the in-depth study of OKC pathogenesis and the advance of treatment concept and surgical techniques, it becomes possible to reduce the rate of postoperative recurrence and simultaneous functional reconstruction of the jaw. To establish standard diagnosis and treatment algorithms or guidelines of OKC, we organized peer experts in China to reach a consensus on pathogenesis, clinical manifestations, imaging characteristics, histopathological features, surgery and postoperative follow-up strategies of OKC for the references of clinicians. Reference | Related Articles | Metrics

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Expert consensus on clinical diagnosis and treatment for Chinese oral mucosal melanoma GUO Wei, REN Guo-xin, SUN Mo-yi, KONG Yun-yi, WANG Li-zhen, BU Rong-fa, RAN Wei, TANG Zhan-gui, LI Long-jiang, MENG Jian, SUN Zhi-jun, SHANG Wei, LV Jiong, WU He-ming, ZHANG Chen-ping, HE Yue, MA Xu-hui, SONG Hao, JU Hou-yu, ZHENG Jia-wei, GONG Zhong-cheng, YANG Kai, ZHANG Jie, WU Yun-teng China Journal of Oral and Maxillofacial Surgery    2021, 19 (6): 481-488.   DOI: 10.19438/j.cjoms.2021.06.001 Abstract （540）      PDF （1408KB）（535）       Knowledge map    [Summary] Head and neck mucosal melanoma (HNMM) is a kind of highly malignant solid tumor. The 5-year survival rate of HNMM is about 20% for a long time. Its pathogenic factors, driving genes, clinical manifestations and treatment methods are quite different from skin melanoma. In 2015, the first Chinese expert consensus on the diagnosis and treatment of head and neck mucosal malignant melanoma was established. After more than six years of application, the clinical diagnosis and treatment of HNMM has been greatly improved. With the deepening of clinical and basic research on mucosal melanoma, the diagnosis, treatment and prognosis of HNMM have changed greatly in recent years, especially with the vigorous development of various branches of head and neck. Oral, nasal, sinus, eye and other mucosal melanoma have developed their own unique diagnosis and treatment model. This consensus can’t meet the actual needs of the current clinical practice. In this regard, the expert group believes that head and neck mucosa contains a wide range of anatomy, involving more clinical departments, and the diagnosis and treatment mode of melanoma varies significantly between different disciplines. It is urgent to meet the clinical consensus of more specialized diagnosis and treatment of individualized treatment and precise treatment. In order to further improve the long-term survival rate and quality of life of oral mucosal melanoma (OMM) and make the consensus to better guide clinical work, this expert group will focus on OMM and conduct in-depth discussion, and establish expert consensus based on evidence-based medicine and empirical medicine. Considering the individual differences of patients, this consensus can be used as a reference for clinical practice of OMM. Reference | Related Articles | Metrics

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Expert consensus on application of submental island flap in oromaxillofacial head and neck defect reconstruction CHEN Chuan-jun, CHEN Wei-liang, SUN Chang-fu, HE Yue, JIANG Can-hua, PENG Xin, SHANG Zheng-jun, HAN Zheng-xue, LI Jin-song, HOU Jin-song, LIN Li-song, HAN Xin-guang, WEI Jian-hua, WANG Zhi-yong, WU Yu-nong, ZHENG Jia-wei, LI Long-jiang, WANG Hui-ming, LI Zu-bing, GUO Chuan-bin, YANG Chi, SHI Bing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2021, 19 (5): 385-391.   DOI: 10.19438/j.cjoms.2021.05.001 Abstract （591）      PDF （5968KB）（459）       Knowledge map    Submental island flap (SMIF) is an axial flap that receives its blood supply from the submental artery, a branch of the facial artery. It is in close proximity with many oral and maxillofacial regions, and provides a good texture and color match. The flap is easy to prepare and suitable for repairing medium-sized defects of the oral and maxillofacial region with high survival rates. However, there are still controversies about the application of submental island flap both at home and abroad, mainly focusing on the oncological safety of submental island flap for patients with cervical lymph node metastasis and the preparation method of the flap. In order to unify and standardize the application of submental island flap in repair of oral and maxillofacial head and neck defects, this paper focuses on the collective wisdom of experts in oral and maxillofacial surgery of many medical colleges in China, and reaches an expert consensus, so as to guide the clinical application of submental island flap. Reference | Related Articles | Metrics

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Progress of multidisciplinary team practice in management of oral squamous cell carcinoma YANG Yue-yi, ZHANG Yi-yi, LI Yi-xin, JU Wu-tong, ZHONG Lai-ping China Journal of Oral and Maxillofacial Surgery    2021, 19 (5): 474-477.   DOI: 10.19438/j.cjoms.2021.05.017 Abstract （316）      PDF （3264KB）（424）       Knowledge map    Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck region. Although the diagnosis and treatment of OSCC have achieved significant improvement, the overall survival has shown little improvement in recent years. Clinical trials are encouraged to promote the diagnosis and treatment as well as update and optimize the clinical guidelines. Multidisciplinary team(MDT) is a model which has demonstrated its superiority in the treatment for intractable OSCC cases, gradually gaining wide adoption and promotion. This paper discussed the role of clinical research MDT in OSCC management. Reference | Related Articles | Metrics

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Re-reconstructions for cases with persistent post-reconstructive orocutaneous or oropharyngocutaneous fistulas after extensive reconstructive operations in head and neck region MA Chun-yue, ZHU Yun, GUO Bing, WANG Liang, SHEN Yi China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 362-367.   DOI: 10.19438/j.cjoms.2021.04.015 Abstract （378）      PDF （1166KB）（393）       Knowledge map    PURPOSE: Orocutaneous or oropharyngeal fistulas may develop after extensive surgery in the head and neck region. This paper described our experiences in applying salvage secondary or tertiary reconstructions in these situations. METHODS: A retrospective study was performed based on the 10-year experiences of secondary or tertiary reconstructions for correction of persistent post-reconstructive orocutaneous or oropharyngocutaneous fistulas in our institution. Thirty-one cases were considered as eligible. The possible causes for these fistulas were recorded. The salvage reconstructive approaches were summarized, while related complications and follow-up outcomes were reported as well. Multivariate statistical analyses for the survival-related factors were performed using SPSS 25 software package. RESULTS: Among all these cases, 19 cases(61.3%) were with post-reconstructive orocutanenous fistulas, while 12(38.7%) were with oropharyngocutaneous fistulas. Anterolateral thigh flaps(n=15, 48.4%) were the most used flaps in the failed prior operations. Most of the cases(n=19, 61.3%) were with histories of prior irradiation. As for the specific salvage reconstructive approaches, 8 cases (25.8%) were re-reconstructed with anterolateral thigh free flaps, while 18(58.1%) were with pectoralis major myocutaneous flaps and 3(9.7%) with fibular flaps, respectively. All re-reconstructive flaps survived postoperatively. Complication rate reached 38.7%(12/31),with pulmonary infections and minor wound dehiscence representing the most likely ones. The overall survival rate reached 58.1%(18/31) calculated at recent follow-ups. CONCLUSIONS: Secondary or tertiary reconstructions for these cases are challenging. Careful planning and considerable expertise in re-reconstructive surgery are both required for successful management of these serious complications. Reference | Related Articles | Metrics

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Evaluation of treatment results of 75 patients with comminuted mandibular fractures XU Xiao-feng, ZHU Fang-xing, LIAO Qian, XU Bing, SHEN Guo-fang, ZHANG Wen-bin, SHI Jun China Journal of Oral and Maxillofacial Surgery    2021, 19 (5): 456-459.   DOI: 10.19438/j.cjoms.2021.05.013 Abstract （324）      PDF （3414KB）（389）       Knowledge map    PURPOSE: This study aimed at proposing a new treatment-oriented classification and treatment algorithm of comminuted mandibular fractures based on analysis of 75 consecutive cases. METHODS: Seventy-five patients with comminuted mandibular fractures were retrospectively reviewed in this study. The classification was based on whether a stable occlusal relationship could be regained, morphology of mandible after trauma, degree of comminution and whether segmental mandibular bone defect happened. Based on traumatic condition, five classes were categorized and conservative treatment, miniplates fixation, reconstruction plates fixation, staged operations fixation with titanium meshes and bone flap transplantation were used for the management of the fracture. Forty-four patients in the experimental group were treated according to the classification while other thirty-one in the control group were not. RESULTS: After surgery, three patients developed infection, one patient presented malocclusion in the experimental group. Four patients developed infection, two patients had bone un-union, two patients presented malocclusion and one patient had mandibular asymmetry in the control group. CONCLUSIONS: The treatment-oriented classification and algorithm for comminuted mandibular fractures provide guidance for the choice of treatment methods and can decrease complication rate but further clinical research is needed. Reference | Related Articles | Metrics

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Research progress of inflammatory microenvironment in NF1 related neurofibroma YOU Yuan-he, WANG Yan-an China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 376-379.   DOI: 10.19438/j.cjoms.2021.04.018 Abstract （286）      PDF （441KB）（352）       Knowledge map    Neurofibroma is one of the characteristic lesions of neurofibromatosis type 1. However, the pathogenesis of neurofibromas is still not completely known. The highly active RAS-GTP signal transduction of Schwann cells with biallelic inactivation can produce a large number of cytokines, which provides a cytokine-rich microenvironment for immune cell recruitment. In normal peripheral nerves, the proportion of immune inflammatory cells is not high. In NF1-related neurofibromas, 30% of the cells are monocytes/macrophages. Mast cells, T cells and dendritic cells (DC) also present. Increased evidences indicate that there is a correlation between inflammation and tumorigenesis. This review summarized the research progress of inflammatory cells in the microenvironment of NF1-related neurofibroma. Reference | Related Articles | Metrics

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The effect of nasal tube stabilization on pressure between tube and nose HU Wen-yue, LYU Xiang, SUN Yu China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 345-349.   DOI: 10.19438/j.cjoms.2021.04.011 Abstract （284）      PDF （733KB）（333）       Knowledge map    PURPOSE: This clinical trial was performed to evaluate the effect of nasal tube stabilization (NTS) on pressure between tube and nose(PTN) in both supine and neck extension position. METHODS: Twenty-four ASAⅠorⅡ adult patients scheduled for oral and maxillofacial surgeries requiring naso tracheal intubation(NTI) were randomly assigned to intubate with either wire-reinforced or Ring-Adair-Elwyn tube. Thin film pressure sensor was used to measure PTN before and after NTS in both supine and neck extension position. Statistical analysis was performed with Graphpad Prism 9.0 software package. RESULTS: The PTN of wire-reinforced tubes were 51 mmHg higher than that of RAE tubes in supine position before NTS (P=0.005), and 68 mmHg higher than that in extension position before NTS (P=0.0007). In wire-reinforced tube group before NTS, the PTN of neck extension position increased by 24 mmHg compared with supine position (P=0.0005). After NTS, the PTN in supine and neck extension position was comparable (P=0.1514). NTS significantly reduced PTN in both supine (P=0.0005) and neck extension position (P=0.0005); while in RAE tube group before NTS, the PTN in supine and neck extension position was comparable (P=0.3394). After NTS, the pressure in supine and neck extension position was comparable(P=0.7910). NTS also significantly reduced PTN in both supine (P=0.0005) and neck extension position (P=0.0005). CONCLUSIONS: NTS effectively reduced PTN of both wire-reinforced and RAE tubes regardless of supine or neck extension position. RAE tube also significantly reduced PTN compared with wire-reinforced tube. Reference | Related Articles | Metrics

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Chinese expert consensus statement on the application of of indocyanine green(ICG) fluorescence imaging in the treatment of oral squamous cell carcinoma WANG Yu-xin, WANG Zhi-yong, WANG Yong-gong, WANG Hui-ming, WANG Li-zhen, TIAN Hao, YE Jin-hai, FU Kun, RUAN Min, SUN Chang-fu, SUN Guo-wen, LIU Fa-yu, XU Bi-yun, HOU Jun, LIU Bing, LIU Liang, CHEN Yong-feng, CHEN Zhan-wei, XIAO Can, LI Si-yi, LI Zhi-yong, LI Yong, LI Nan, ZHANG Chen-ping, ZHANG Dong-sheng, ZHANG Sheng, ZHANG Kai, YANG Xi, HE Wei, SU Tong, JI Tong, LIN Li-song, LUO Rui-hua, ZHAO Zhi-li, HU Qin-gang, TANG Zhan-gui, XU Wei-jia, HUANG Zhi-quan, HUANG Xiao-feng, LIANG Yu-jie, HAN Zheng-xue, HAN Wei, JIANG Can-hua, YU Jian-jun, CAI Zhi-gang, LIAO Gui-qing, LIAO Sheng-kai, CAI Hui-ming, WEI Jian-hua China Journal of Oral and Maxillofacial Surgery    2022, 20 (1): 1-6.   DOI: 10.19438/j.cjoms.2022.01.001 Abstract （601）      PDF （847KB）（331）       Knowledge map    Indocyanine green (ICG) is a near-infrared fluorescent dye. Based on the enhanced permeability and retention (EPR) effect, the ICG fluorescence imaging was applied extensively in biomedical fields. The technique could sensitively detect imaging difference between the tumor and surrounding tissue, and define the tumor border to assist in tumor resection. Nevertheless, the application in the treatment of oral squamous cell carcinoma (OSCC) is still at the neonate stage. Thereby, its indication, standard operation procedure and caution required normalization. On the Evidence-based approaches including multi-center study, systemic reviews of related scientific publications,the Chinese experts reach a consensus of ICG fluorescence imaging technique to instruct the clinical practice of OSCC surgery. Reference | Related Articles | Metrics

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Preoperative finite element analysis of fibula myocutaneous flap for segmental mandibular reconstruction WANG Yi-zhou, CAI Man, SUN Li-fan, ZHU Qing-hai, HOU Chen-xing, HAN Wei, TANG Yu-ting, SUN Nan-nan, WANG Chen-xing, LI Huai-qi, YE Jin-hai China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 325-331.   DOI: 10.19438/j.cjoms.2021.04.007 Abstract （338）      PDF （1665KB）（328）       Knowledge map    PURPOSE: To explore the biomechanical reasons of mandible deviation after vascularized fibular myocutaneous flap repair and reconstruction of large-area segmental defect of mandible by using finite element static analysis method, and to verify the effectiveness of the analysis through postoperative follow-up, so as to obtain a research method that can provide reference for the design of operation plan before operation. METHODS: Ten cases of traditional surgery and 10 cases of digital technology for mandibular segmental resection and vascularized fibula reconstruction were included in this study. Based on a case of digital preoperative three-dimensional surgery, the three-dimensional finite element analysis model of mandible reconstruction was established to analyze the strain trend. Then cone-beam CT (CBCT) data of postoperative follow-up and preoperative CBCT data were compared. GraphPad Prism 8 software package was used for statistical analysis. RESULTS: There was no significant difference between the two groups before and after operation; but compared with the traditional group, the change of joint space of the affected side in the digital group was significantly reduced(P<0.05). Based on the preoperative operation plan of a case using digital technology, the finite element analysis model was successfully established, and the results showed that the condyle of the affected side (right side) rotated clockwise in the transverse position; the epicondyle rotated inward in the coronal position; the coronal process shifted outward and downward in the sagittal position. The CBCT images before and 6 months after operation were compared, and the jaw displacement trend was consistent with the findings of finite element analysis. CONCLUSIONS: Finite element analysis can qualitatively analyze the deviation of mandible after reconstruction of mandible defect with vascularized fibula flap using improved digital guide plate technology, and provide reference for the design of operation plan before operation. Reference | Related Articles | Metrics

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Long term survival of mature autotransplanted teeth in 41 consecutive cases LU Li-rong, DING Xu, LIU Yu-chan China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 354-357.   DOI: 10.19438/j.cjoms.2021.04.013 Abstract （1637）      PDF （658KB）（318）       Knowledge map    PURPOSE: To investigate the long term survival of mature autotransplanted teeth, so as to provide reference for clinical application. METHODS: The clinical data of 41 patients (46 teeth) who underwent mature autotransplanted teeth were retrospectively analyzed. All patients were followed up regularly for clinical examination and X-ray examination. The 5-year cumulative survival rate and cumulative success rate of all implantations were analyzed. Digital X-ray film was used to detect the lesions, then the effects of gender, age and root canal therapy on the cumulative survival rate and success rate of implantations were analyzed with SPSS 19.0 software package. RESULTS: During the 5-year follow-up period, the cumulative survival rate was 84.78% (39/46), and the cumulative success rate was 71.74% (33/39). The lesions were detected in 10 of the 46 mature autotransplanted teeth, with a detection rate of 21.74%. The effect of root canal treatment showed significant impact on the cumulative success rate of mature autotransplanted teeth(P<0.05). CONCLUSIONS: The 5-year cumulative survival rate and cumulative success rate of mature autotransplanted teeth are relatively high, so it can be used in restoration of dentition defect; moreover, root canal therapy after implantation can effectively improve the success rate. Reference | Related Articles | Metrics

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Application of lineage tracing technique based on Cre/Loxp recombinase system in the study of osteogenic remodeling XU Ning-wei, WANG Jing, GONG Jia-jing, ZHANG Jin, JIN An-ting, JIANG Ling-yong China Journal of Oral and Maxillofacial Surgery    2021, 19 (6): 562-567.   DOI: 10.19438/j.cjoms.2021.06.015 Abstract （234）      PDF （735KB）（298）       Knowledge map    [Summary] Cell lineage tracing technology is an important tool to study the characteristics of stem cells, among which, the one based on Cre/Loxp recombinase system is a great breakthrough. General recombinase system realizes the tissue specificity of reporter gene, based on which, inducible recombinase system makes controlling the expression time of reporter gene possible. The study of the mechanism of osteogenic remodeling is related to the fate of osteoblast lines, which is of great significance to the study of bone remodeling and the application of tissue engineering. This paper reviewed the application of lineage tracing technique based on Cre/Loxp recombinase system in the study of the origin, differentiation, lineage and hierarchy of osteoblast lines and their function in development and repair, and discussed its scope of application, advantages and disadvantages. Reference | Related Articles | Metrics

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Application of atelo-collagen for distal bone defect restoration of the second molar after mandibular third molar extraction: a split-mouth clinical trial GUO Ya-rong, LU Xu-guang, WANG Xing, CHENG Yong-feng, HE Dong-ning China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 332-336.   DOI: 10.19438/j.cjoms.2021.04.008 Abstract （364）      PDF （1023KB）（295）       Knowledge map    PURPOSE: To evaluate the clinical effect of atelo-collagen grafting on reconstruction of intrabony defects of the second molar after mandibular third molar extraction. METHODS: Thirty-two patients who had their mandibular third molars extracted at Shanxi Medical University Hospital of Stomatology from January 2019 to July 2019 were included in this study. Bilateral mandibular third molars were in horizontal position in all patients. After extraction, the same person's tooth sockets were divided into two groups: the control group and the atelo-collagen group. The tooth sockets in the control group received colloidal silver gelatin sponge, while in the atelo-collagen group atelo-collagen was used to fill the sockets. The patients were followed up for 3, 6 months. Assessments of distal buccal probing depth of the second molar and X-ray examination were performed 3, 6 months postoperatively. The data were analyzed with SPSS 24.0 software package. RESULTS: Probing depths were improved after operation in both groups. There was no significant difference between the two groups. The height and bone density of the new bone in the atelo-collagen group were significantly higher than those in the control group(P<0.001). Three months after operation, the volume of new bone in the atelo-collagen group was significantly larger than the control group. CONCLUSIONS: Atelo-collagen can promote bone regeneration and reconstruction in the intrabony defect of second molar caused by extraction of mandibular third molar. Reference | Related Articles | Metrics

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Current evidence-based treatment of infantile hemangiomas ZHENG Jia-wei, ZHAO Ze-liang, CHEN Qi-ming China Journal of Oral and Maxillofacial Surgery    2022, 20 (1): 7-14.   DOI: 10.19438/j.cjoms.2022.01.002 Abstract （262）      PDF （1222KB）（290）       Knowledge map    Infantile hemangioma is the most common benign tumor in childhood. Early intervention is currently advocated so as to minimize complications and negative effects on mental development. With the successful application of various β-blockers, the treatment methods have undergone revolutionary changes, and the treatment effect has also been improved. Based on literature review and evidence-based medicine, this article summarized the indications, advantages and disadvantages and selection of various treatment methods for infantile hemangioma, in order to provide guidance for clinical application. Reference | Related Articles | Metrics

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Effect of POLD1 on proliferation and invasion of oral squamous cell carcinoma and its regulatory mechanism ZHANG Ying, WU Li, CHEN Yu-ling, LIN Yun-tao, SHEN Yue-hong, YANG Hong-yu China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 302-308.   DOI: 10.19438/j.cjoms.2021.04.003 Abstract （274）      PDF （2043KB）（280）       Knowledge map    PURPOSE: To investigate the effect of POLD1 expression on cell proliferation, migration, invasion and cell cycle of oral squamous cell carcinoma (OSCC) cell lines and the relevant mechanism. METHODS: Online data were used to analyze POLD1 expression in head and neck squamous cell carcinoma (HNSCC) samples and normal tissues. POLD1 expression was evaluated in OSCC and normal tissues using immunohistochemistry. OSCC cell lines（SCC9 and CAL27) were infected with lentivirus, and the expression of POLD1 in stable cell lines was detected by Western blot. CCK-8 assay and EdU assay were used to detect cell proliferation; wound healing assay and Transwell migration and invasion assay were used to detect cell migration and invasion. The effect of POLD1 on cell cycle was detected by flow cytometry and the related pathway was studied via Western blot. SPSS 21.0 software package and GraphPad Prism were used for data analysis and plotting. RESULTS: POLD1 was abnormally upregulated in head and neck squamous cell carcinoma and OSCC tissues (P<0.001). Depletion of POLD1 in OSCC cells not only inhibited proliferation, migration, and invasion of cancer cells but also resulted in G2 arrest. The expression of P-Cdc2(Tyr15) and P-Rb(Ser807) in the experiment group were significantly increased. CONCLUSIONS: Down-regulation of POLD1 inhibits proliferation, migration and invasion of OSCC cells. Reference | Related Articles | Metrics

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Application of virtual surgical planning in transoral mandibulectomy and accurate mandible reconstruction: report of 9 consecutive cases YANG Xin, LYU Ming-ming, LI Jun, SUN Jian China Journal of Oral and Maxillofacial Surgery    2021, 19 (5): 469-473.   DOI: 10.19438/j.cjoms.2021.05.016 Abstract （277）      PDF （4007KB）（269）       Knowledge map    PURPOSE: This study was aimed to introduce the experience of mandibulectomy and vascularized bone reconstruction via intraoral approach assisted by virtual surgical plan and evaluate the effect of postoperative reconstruction. METHODS: Nine patients with benign tumor in the mandible underwent preoperative virtual surgical planning, then screw-predesignated osteotomy guide plate suitable for intraoral operation was designed and manufactured. Mandibulectomy was performed with cutting guide plate, prebent titanium plate and vascularized bone flap were implanted and fixed via intraoral approach. Intraoperative real-time navigation was used to confirm and correct the spatial location of the neo-mandible. The postoperative appearance and function of the patients were evaluated by clinical and imaging examination, and the accuracy of mandibular reconstruction was evaluated by superimposing postoperative CT on preoperative STL model after six months. SPSS 15.0 software package was used for statistical analysis. RESULTS: Aided with the virtual surgical plan, all patients in this series successfully underwent mandibulectomy and reconstruction with vascularized bone flap via intraoral approach. Intraoperative navigation confirmed the correct location of the reconstructed mandible. All patients showed facial symmetry, no facial paralysis and mouth opening limitation at 6-month postoperative visit were noted. All patients were satisfied with the results of the operation. Image fitting showed that the osteotomy line position was accurate with an error of less than 1 mm [(0.72±0.15)mm], and the reconstructed position of the mandible was highly consistent with preoperative design with an error of (1.76±1.99)mm. CONCLUSIONS: Under the guide of virtual surgical planning, intraoral mandibulectomy and vascularized bone reconstruction could be successfully performed by using screw-predesignated guide plate and prebent titanium plate, avoiding extraoral incision and significantly improving the accuracy of mandibular reconstruction. Reference | Related Articles | Metrics

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The effect of quality control circle on improving the compliance of postoperative functional exercise in patients with temporomandibular joint disease SUN Ming-yuan, YU Lei-lei, GU Ya-jie, XIA Di China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 340-344.   DOI: 10.19438/j.cjoms.2021.04.010 Abstract （279）      PDF （726KB）（269）       Knowledge map    PURPOSE: To explore the practical effect of quality control circle (QCC) movement on improving the compliance of postoperative functional exercise in patients undergoing temporomandibular joint(TMJ) anchorage surgery. METHODS: A convenience sampling method was used to select 50 cases with temporomandibular joint diseases (TMD) diagnosed in the Department of Oral Surgery as the control group from July 2019 to August 2019, and 50 cases were selected as the experimental group using the same method from December 2019 to January 2020. Patients in the control group were given routing nursing care. QCC program with the theme of "Improving postoperative functional exercise compliance of patients with temporomandibular disorder" was conducted in the experimental group, in which common quality control tools were used to analyze the causes and made strategies for those with low functional exercise compliance. The functional exercise compliance, pain score and maximum mouth opening were compared between the two groups. SPSS 20.0 software package was used for statistical analysis. RESULTS: The functional exercise compliance of TMD patients increased from 57.90% to 87.78%, maximum mouth opening at postoperative 1 month increased from (26.54±5.33)mm to (28.32±4.67)mm(P<0.05), while VAS score of pain decreased from 2.48±1.084 to 1.40±0.957(P<0.05). CONCLUSIONS: Implementation of QCC program has positive effect on improving the postoperative functional exercise compliance and the joint function recovery of TMD patients, promoting the comprehensive ability of nurses and assuring the nursing quality. Reference | Related Articles | Metrics

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Effect of SREBP2 on proliferation and migration of oral squamous cell carcinoma and its regulatory mechanism GUO Ming, CHEN Yu-ling, WU Li, ZHANG Bi-ru, SHEN Yue-hong, YANG Hong-yu China Journal of Oral and Maxillofacial Surgery    2021, 19 (4): 295-301.   DOI: 10.19438/j.cjoms.2021.04.002 Abstract （324）      PDF （1479KB）（264）       Knowledge map    PURPOSE: To investigate the effect of sterol regulatory element-binding protein 2 (SREBP2) on the malignant biological behaviors of oral squamous cell carcinoma (OSCC) cell lines. METHODS: The expression of SREBP2 in OSCC was detected by qRT-PCR. SiRNA and overexpression plasmids were constructed and transferred into CAL27. The ability of cell proliferation was detected by cell counting kit-8(CCK-8) assay and EdU cell-proliferation assay; the level of apoptosis was detected by flow cytometry; the ability of migration and invasion was detected by wound-healing assay and Transwell migration and invasion assays. Western blotting was used to detect the expression of SREBP2-related proteins. The data were plotted by Graphpad 5.0; Student's t tests were used to evaluate difference among groups. RESULTS: The expression of SREBP2 in 50 pairs of OSCC tissues and OSCC cell lines was significantly lower than that in normal controls. Knock-down and overexpression experiments showed that the change of SREBP2 expression affected the malignant biological behavior of OSCC cells and affected the development of OSCC through MVA signal pathway. CONCLUSIONS: SREBP2 inhibits proliferation, migration, invasion and promotes apoptosis of cancer cells in OSCC. Reference | Related Articles | Metrics