口服普萘洛尔联合外用盐酸倍他洛尔治疗8例眶周高风险婴幼儿血管瘤的疗效和安全性评价

doi:10.19438/j.cjoms.2020.03.015

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (3): 264-268.doi: 10.19438/j.cjoms.2020.03.015

口服普萘洛尔联合外用盐酸倍他洛尔治疗8例眶周高风险婴幼儿血管瘤的疗效和安全性评价

李红, 周昱川, 龚忠诚, 孙杨, 凌彬

新疆医科大学第一附属医院·附属口腔医院颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐 830054

收稿日期:2019-10-31 修回日期:2020-01-14 发布日期:2020-06-18
通讯作者: 凌彬,E-mail:34527623@qq.com
作者简介:李红（1992-）,女,在读硕士研究生,E-mial:404950863@qq.com
基金资助:
中华口腔医学会西部口腔医学临床科研基金(CSA-W2019-01)

Oral propranolol combined with topical betaxolol for 8 children with high-risk infantile hemangiomas involving periocular region

LI Hong, ZHOU Yu-chuan, GONG Zhong-cheng, SUN Yang, LING Bin

Oncological Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Xinjiang Medical University/Hospital of Stomatology; Institute of Stomatology, Xinjiang Uygur Autonomous Region. Urumuqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2019-10-31 Revised:2020-01-14 Published:2020-06-18

摘要/Abstract

摘要： 目的评价口服普萘洛尔联合外用盐酸倍他洛尔滴眼液治疗眶周婴幼儿血管瘤的临床疗效和安全性。方法对2014年8月—2019年1月就诊于新疆医科大学第一附属医院·附属口腔医院的8例高风险眶周婴幼儿血管瘤,给予口服普萘洛尔,剂量为0.5~2 mg/（kg·d）;结合外敷盐酸倍他洛尔滴眼液,2次/d,10 min/次,联合用药6个月~1年或瘤体完全治愈。比较用药前、后瘤体面积、厚度、颜色、局部血流峰值,结合患儿用药期间的不良反应,评估临床疗效及安全性。采用SPSS 23.0软件包对数据进行统计学分析。结果 8例患儿平均疗程为9.4个月,停药时平均效果评分为77分,疗效评价为4例Ⅳ级,4例Ⅲ级。用药期间无严重不良反应发生。结论口服普萘洛尔联合外用盐酸倍他洛尔滴眼液治疗眶周高风险婴幼儿血管瘤安全有效。

关键词: 婴幼儿血管瘤, 普萘洛尔, 盐酸倍他洛尔, 眶周

Abstract: PURPOSE: To assess the efficacy and safety of oral propranolol combined with betaxolol for high-risk infantile hemangiomas involving periocular region. METHODS: From August 2014 to January 2019 in 8 pediatric patients with high-risk hemangiomas, propranolol was administered orally at a daily dose of 0.5-2 mg/kg, betaxolol was applied to the tumor surface for ten minutes twice a day. The treatment lasted for half to one year or until a full recovery was achieved. The efficiency and safety of this treatment was assessed based on the changes of size, thickness, color, local peak systolic velocity before and after treatment and side effects during the therapy. SPSS 23.0 software package was used for statistical analysis. RESELTS: The mean treatment duration was 9.4 months and the mean score of efficacy was 77 points of 8 patients. The clinical response were evaluated as four patients for grade Ⅳ and another four for grade Ⅲ. No severe complications were observed. CONCLUSIONS: Oral propranolol combined with topical betaxolol is an effective and safe treatment for high-risk infantile hemangiomas involving periocular region.

Key words: Infantile hemangiomas, Propranolol, Betaxolol, Periocular region

中图分类号:

R739.8

李红, 周昱川, 龚忠诚, 孙杨, 凌彬. 口服普萘洛尔联合外用盐酸倍他洛尔治疗8例眶周高风险婴幼儿血管瘤的疗效和安全性评价[J]. 中国口腔颌面外科杂志, 2020, 18(3): 264-268.

LI Hong, ZHOU Yu-chuan, GONG Zhong-cheng, SUN Yang, LING Bin. Oral propranolol combined with topical betaxolol for 8 children with high-risk infantile hemangiomas involving periocular region[J]. China J Oral Maxillofac Surg, 2020, 18(3): 264-268.

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口服普萘洛尔联合外用盐酸倍他洛尔治疗8例眶周高风险婴幼儿血管瘤的疗效和安全性评价

Oral propranolol combined with topical betaxolol for 8 children with high-risk infantile hemangiomas involving periocular region

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