口服普萘洛尔治疗婴幼儿鼻部血管瘤临床疗效评价

doi:10.19438/j.cjoms.2017.02.010

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (2): 147-152.doi: 10.19438/j.cjoms.2017.02.010

口服普萘洛尔治疗婴幼儿鼻部血管瘤临床疗效评价

赵志国, 潘遥, 杨东升, 张力平

中国医科大学附属盛京医院口腔颌面外科,辽宁沈阳 110004

收稿日期:2016-04-29 出版日期:2017-03-20 发布日期:2017-04-13
通讯作者: 张力平,E-mail:471535881@qq.com
作者简介:赵志国（1980-）,男,硕士,主治医师,E-mail: zhaozg@sj-hospital.org

Efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses

ZHAO Zhi-guo, PAN Yao, YANG Dong-sheng, ZHANG Li-ping

Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China

Received:2016-04-29 Online:2017-03-20 Published:2017-04-13
Contact: 辽宁省科学技术计划（2011225020）

摘要/Abstract

摘要： 目的评价口服普萘洛尔治疗婴幼儿鼻部血管瘤的临床疗效和安全性。方法 2013年3月—2015年3月,对确诊为婴幼儿鼻部血管瘤的29例患儿采用口服普萘洛尔2.0 mg/（kg·d）治疗,分2次口服。每3~4周复诊1次,定期拍照,动态观察血管瘤的大小、质地、颜色变化,随时处理治疗过程中的不良反应,根据Achauer 疗效判定标准进行疗效评价。结果 29例患儿平均口服普萘洛尔6个月。疗效Ⅰ级（差）0例,Ⅱ级（中）2例,Ⅲ级（好）9例,Ⅳ级（优）18例;2例患儿出现轻度腹泻,2例出现睡眠障碍,未发生严重不良反应。结论口服普萘洛尔治疗婴幼儿鼻部血管瘤起效快,疗效好,不良反应轻微,可作为首选方法。

关键词: 血管瘤, 普萘洛尔, 婴幼儿

Abstract: PURPOSE : To estimate the efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses. METHODS : From March, 2013 to March, 2015, 29 infantile hemangiomas in the noses were treated with oral propranolol at a dose of 2.0 mg/(kg·d), divided into 2 times. The changes of the tumor size, texture and color were monitored and recorded at a regular interval. The adverse reactions after medication were observed and managed accordingly. The efficacy was evaluated using Achauer's system. RESULTS : The average mediation duration was 6 months. The overall response was gradeⅡ in 2 patients, grade Ⅲ in 9 patients, grade Ⅳ in 18 patients. Adverse reactions were observed in 2 patients, including mild diarrhea and sleep disturbance. CONCLUSION S: Oral propranolol is effective and safe for the treatment of infantile hemangiomas in the noses, and the adverse reaction is minimal.

Key words: Hemangioma, Propranolol, Infant

中图分类号:

R732.2

赵志国, 潘遥, 杨东升, 张力平. 口服普萘洛尔治疗婴幼儿鼻部血管瘤临床疗效评价[J]. 中国口腔颌面外科杂志, 2017, 15(2): 147-152.

ZHAO Zhi-guo, PAN Yao, YANG Dong-sheng, ZHANG Li-ping. Efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses[J]. China J Oral Maxillofac Surg, 2017, 15(2): 147-152.

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口服普萘洛尔治疗婴幼儿鼻部血管瘤临床疗效评价

Efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses

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