婴幼儿血管瘤循证治疗现状

doi:10.19438/j.cjoms.2022.01.002

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (1): 7-14.doi: 10.19438/j.cjoms.2022.01.002

婴幼儿血管瘤循证治疗现状

郑家伟, 赵泽亮, 陈启铭

上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海 200011

收稿日期:2021-09-20 修回日期:2021-10-18 出版日期:2022-01-20 发布日期:2022-01-20
通讯作者: 郑家伟,E-mail: davidzhengjw@hotmail.com
作者简介:郑家伟（1964-）,男,博士,教授,博士研究生导师
基金资助:
国家自然科学基金（82071130）

Current evidence-based treatment of infantile hemangiomas

ZHENG Jia-wei, ZHAO Ze-liang, CHEN Qi-ming

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2021-09-20 Revised:2021-10-18 Online:2022-01-20 Published:2022-01-20

摘要/Abstract

摘要： 婴幼儿血管瘤是儿童期最常见的良性肿瘤,目前主张早期予以干预,以减少并发症和对心理发育的负面影响。随着β受体阻滞剂的成功应用,治疗方法发生了革命性变化,治疗效果也随之提高。本文结合文献分析,基于循证医学证据,概述了婴幼儿血管瘤各种治疗方法的适应证、优缺点和选择依据,以期为临床应用提供指导。

关键词: 婴幼儿血管瘤, 循证治疗, β受体阻滞剂

Abstract: Infantile hemangioma is the most common benign tumor in childhood. Early intervention is currently advocated so as to minimize complications and negative effects on mental development. With the successful application of various β-blockers, the treatment methods have undergone revolutionary changes, and the treatment effect has also been improved. Based on literature review and evidence-based medicine, this article summarized the indications, advantages and disadvantages and selection of various treatment methods for infantile hemangioma, in order to provide guidance for clinical application.

Key words: Infantile hemangioma, Evidence-based treatment, Beta receptor blockers

中图分类号:

R739.8

郑家伟, 赵泽亮, 陈启铭. 婴幼儿血管瘤循证治疗现状[J]. 中国口腔颌面外科杂志, 2022, 20(1): 7-14.

ZHENG Jia-wei, ZHAO Ze-liang, CHEN Qi-ming. Current evidence-based treatment of infantile hemangiomas[J]. China J Oral Maxillofac Surg, 2022, 20(1): 7-14.

参考文献

[1] Kilcline C, Frieden IJ.Infantile hemangiomas: how common are they? a systematic review of the medical literature[J]. Pediatr Dermatol,2008,25(2):168-173.
[2] 郑家伟. 婴幼儿血管瘤“等待观察”的治疗策略应予改变[J].中国口腔颌面外科杂志,2012,10(2):163-164.
[3] Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy[J]. N Engl J Med, 2008,358(24):2649-2651.
[4] Moyakine AV, Herwegen B, van der Vleuten CJM. Use of the Hemangioma Severity Scale to facilitate treatment decisions for infantile hemangiomas[J]. J Am Acad Dermatol, 2017,77(5):868-873.
[5] Janmohamed SR, de Waard-van der Spek FB, Madern GC, et al.Scoring the proliferative activity of haemangioma of infancy: the Haemangioma Activity Score (HAS)[J]. Clin Exp Dermatol, 2011,36(7):715-723.
[6] Haggstrom AN, Beaumont JL, Lai JS, et al.Measuring the severity of infantile hemangiomas: instrument development and reliability[J]. Arch Dermatol, 2012,148(2):197-202.
[7] Sebaratnam D, Rodríguez Bandera AI, Wong LF, et al.Infantile hemangioma. part 2: management[J]. Am Acad Dermatol, 2021,85(6):1395-1404.
[8] Overman J, Fontaine F, Wylie-Sears J, et al.R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma[J]. ELife, 2019,8:e43026.
[9] Solman L, Glover M, Beattie PE, et al.Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology 406 consensus guidelines[J]. Brit J Dermatol, 2018,179(3):582-589.
[10] Smithson SL, Rademaker M, Adams S, et al.Consensus statement for the treatment of infantile haemangiomas with propranolol[J]. Australas J Dermatol, 2017,58(2):155-159.
[11] Shah SD, Baselga E, McCuaig C, et al. Rebound growth of infantile hemangiomas after propranolol therapy[J]. Pediatrics, 2016,137(4):e20151754.
[12] Caussé S, Aubert H, Saint-Jean M, et al.Propranolol-resistant infantile haemangiomas[J]. Brit J Dermatol,2013,169(1):125-129.
[13] Zhao ZL, Liu C, Zheng JW, et al.Oral atenolol treatment for infantile hemangiomas: clinical analysis of 133 consecutive patients[J]. Ann Transl Med,2021,9(2):116.
[14] 王琦,向波,吉毅,等.普萘洛尔与阿替洛尔治疗婴儿血管瘤的比较研究[J].中华皮肤科杂志,2016,49(10):683-687.
[15] Laurens C, Abot A, Delarue A, et al.Central effects of beta-blockers may be due to oxide and hydrogen peroxide release independently of their ability to cross the blood-brain barrier[J]. Front Neurosci, 2019,13:33.
[16] Aly MM, Hamza AF, Abdel Kader HM, et al.Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma[J]. Eur J Pediatr, 2015,174(11):1503-1509.
[17] Liu C, Zhao Z, Wu H, et al.Effect of combined low-dose oral prednisone with beta-adrenergic receptor antagonists for refractory infantile hemangiomas: retrospective cohort study in 76 patients[J]. Ann Transl Med, 2019,7(23):750.
[18] Gnarra M, Solman L, Harper J, et al.Propranolol and prednisolone combination for the treatment of segmental haemangioma in PHACES syndrome[J]. Br J Dermatol, 2015,173(1):242-246.
[19] Davila-Osorio VL, Iznardo H, Roe E, et al.Propranolol-resistant infantile hemangioma successfully treated with sirolimus[J]. Pediatr Dermatol, 2020,37(4):684-686.
[20] Zaher H, Rasheed H, El-Komy MM, et al.Propranolol versus captopril in the treatment of infantile hemangioma (IH): a randomized controlled trial[J]. J Amer Acad Dermatol, 2016,74(3):499-505.
[21] Wu HW, Liu C, Wang X, et al.Topical application of 0.5% timolol maleate hydrogel for the treatment of superficial infantile hemangioma[J]. Front Oncol,2017,7:137.
[22] M Hill I, Stefanko N, Drolet BA. Comment on "doing the math: a simple approach to topical timolol dosing for infantile hemangiomas"[J]. Pediatr Dermatol, 35(5):698-699.
[23] Danarti R, Ariwibowo L, Radiono S, et al.Topical timolol maleate 0.5% for infantile hemangioma: its effectiveness compared to ultrapotent topical corticosteroids - a single-center experience of 278 cases[J]. Dermatology, 2016,232(5):566-571.
[24] Hartmann F, Lockmann A, Gronemeyer LL, et al.Nd:YAG and pulsed dye laser therapy in infantile haemangiomas: a retrospective analysis of 271 treated haemangiomas in 149 children[J]. J Eur Acad Dermatol Venereol, 2017,31(8):1372-1379.
[25] Jin WW, Tong Y, Wu JM, et al.Observation on the effects of 595- nm pulsed dye laser and 755- nm long-pulsed alexandrite laser on sequential therapy of infantile hemangioma[J]. J Cosmet Laser Ther, 2020,22(3):159-164.
[26] Pandey V, Tiwari P, Sharma SP, et al.Role of intralesional bleomycin and intralesional triamcinolone therapy in residual haemangioma following propranolol[J]. Int J Oral Maxillofac Surg, 2018,47(7):908-912.
[27] Waner M.The surgical management of infantile hemangiomas[J]. Otolaryngol Clin North Am, 2018,51(1):125-131.
[28] Fernández Faith E, Shah S, Witman PM, et al.Clinical features, prognostic factors, and treatment interventions for ulceration in patients with infantile hemangioma[J]. JAMA Dermatol, 2021,157(5):566-572.
[29] Frieden IJ, Püttgen KB, Drolet BA, et al.Management of infantile hemangiomas during the COVID pandemic[J]. Pediatric Dermatol, 2020,37(3):412-418.

婴幼儿血管瘤循证治疗现状

Current evidence-based treatment of infantile hemangiomas

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