外涂盐酸倍他洛尔滴眼液治疗7例表浅型婴幼儿血管瘤疗效观察

doi:10.19438/j.cjoms.2017.05.013

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (5): 438-441.doi: 10.19438/j.cjoms.2017.05.013

外涂盐酸倍他洛尔滴眼液治疗7例表浅型婴幼儿血管瘤疗效观察

周昱川，凌彬，龚忠诚，许颖捷，陈青立

新疆医科大学第一附属医院口腔医学中心颌面肿瘤外科，新疆乌鲁木齐 830054

收稿日期:2017-01-04 出版日期:2017-08-30 发布日期:2017-10-27
通讯作者: 龚忠诚，E-mail：565249755@qq.com
作者简介:周昱川（1989-），女，在读硕士研究生，E-mail：843806258@qq.com

Treatment of 7 superficial infantile hemangiomas with betaxolol hydrochloride eye drops

ZHOU Yu-chuan, LING Bin, GONG Zhong-cheng, XU Ying-jie, CHEN Qing-li.

Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University. Urumqi 830054, Xinjiang Autonomous Region, China

Received:2017-01-04 Online:2017-08-30 Published:2017-10-27

摘要/Abstract

摘要： 目的：探讨局部外用盐酸倍他洛尔滴眼液治疗表浅型婴幼儿血管瘤的临床疗效及安全性。方法：选择7 例表浅型婴幼儿血管瘤患者，其中男3例，女4例，年龄30~156 d，平均年龄97 d。在瘤体表面外涂盐酸倍他洛尔滴眼液，年龄大于2个月的患儿每天外涂5次，年龄不足2个月的患儿每天外涂3次。分别记录用药前、后的瘤体颜色、大小、张力、厚度等变化，同时观察用药后不良反应，评估用药安全性。结果：治疗后，7例患儿的瘤体均不同程度地面积缩小、质地变软及颜色消退，所有患儿均未出现可检测到的不良反应。结论：外涂盐酸倍他洛尔滴眼液能有效促进血管瘤消退，且未发现不良反应，有望作为治疗婴幼儿血管瘤一种有效的辅助治疗方法。

关键词: 婴幼儿血管瘤, 盐酸倍他洛尔滴眼液, β受体阻滞剂

Abstract: PURPOSE: To explore the clinical efficacy and safety of betaxolol hydrochloride eye drops treatment for superficial infantile hemangiomas. METHODS: Among 31 cases with superficial infantile hemangiomas, 7 patients (3 males and 4 females) with superficial infantile hemangiomas were selected　according to inclusion criteria, their age ranged from 30 days to 156 days, with an average age of 97 days. Betaxolol hydrochloride eye drops were applied on the tumor surface, 5 times per day in children older than 2 months, and 3 times per day in children less than 2 months. The changes of color, size, tension and thickness were recorded before and after treatment, and adverse reactions were observed in order to evaluate the safety of the treatment. RESULTS: After treatment, 7 patients had varying degrees of reduction and softened texture, the lesion color faded, no adverse reactions were noted. CONCLUSIONS: Betaxolol hydrochloride eye drops might be one of the effective ways to treat superficial infantile hemangiomas with less adverse reaction.

Key words: Infantile ｈemangiomas, Betaxolol hydrochloride eye drops, β-adrenergic receptor blocker

中图分类号:

R782.2

周昱川，凌彬，龚忠诚，许颖捷，陈青立. 外涂盐酸倍他洛尔滴眼液治疗7例表浅型婴幼儿血管瘤疗效观察[J]. 中国口腔颌面外科杂志, 2017, 15(5): 438-441.

ZHOU Yu-chuan, LING Bin, GONG Zhong-cheng, XU Ying-jie, CHEN Qing-li.. Treatment of 7 superficial infantile hemangiomas with betaxolol hydrochloride eye drops[J]. China J Oral Maxillofac Surg, 2017, 15(5): 438-441.

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外涂盐酸倍他洛尔滴眼液治疗7例表浅型婴幼儿血管瘤疗效观察

Treatment of 7 superficial infantile hemangiomas with betaxolol hydrochloride eye drops

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