口服普萘洛尔治疗婴幼儿血管瘤中国专家共识（2022版）

doi:10.19438/j.cjoms.2022.04.001

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (4): 313-319.doi: 10.19438/j.cjoms.2022.04.001

口服普萘洛尔治疗婴幼儿血管瘤中国专家共识（2022版）

郑家伟^1,*, 王绪凯^2,*, 秦中平³, 范新东⁴, 李凯⁵, 杨耀武⁶, 霍然⁷, 刘少华⁸, 赵吉宏⁹, 汪小勇¹⁰, 周德凯¹¹, 刘学键¹²

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011;
2.中国医科大学口腔医学院口腔颌面外科, 辽宁沈阳 110001;
3.山东省临沂市肿瘤医院省A级血管瘤特色专科,山东临沂 276001;
4.上海交通大学医学院附属第九人民医院介入科,上海 200011;
5.复旦大学附属儿科医院外科,上海 201102;
6.空军军医大学口腔医学院头颈肿瘤外科,陕西西安 710032;
7.山东第一医科大学附属省立医院（山东省立医院）烧伤整形美容外科,山东济南 250021;
8.山东大学齐鲁医院口腔颌面外科,山东济南 250012;
9.武汉大学口腔医学院口腔外科,湖北武汉 430079;
10.上海曹安医院血管瘤科,上海 201804;
11.重庆医科大学附属儿童医院胃肠新生儿外科血管瘤专科,重庆 400014;
12.山东省立第三医院两腺与血管瘤科,山东济南 250012

收稿日期:2022-06-01 修回日期:2022-06-15 出版日期:2022-07-20 发布日期:2022-07-20
通讯作者: 王绪凯,E-mail: wangxukai757892@sina.com;郑家伟,E-mail:davidzhengjw@hotmail.com。^*共同通信作者
作者简介:郑家伟(1964-) ,男,博士,教授,博士研究生导师
基金资助:
国家自然科学基金（82071130）

Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022)

ZHENG Jia-wei¹, WANG Xu-kai², QIN Zhong-ping³, FAN Xin-dong⁴, LI Kai⁵, YANG Yao-wu⁶, HUO Ran⁷, LIU Shao-hua⁸, ZHAO Ji-hong⁹, WANG Xiao-yong¹⁰, ZHOU De-kai¹¹, LIU Xue-jian¹²

1. Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
2. Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University; Liaoning Institute of Dental Research. Shenyang 110001, Liaoning Province;
3. Special Department of Hemangioma, Tumor Hospital of Linyi City. Linyi 276001, Shandong Province;
4. Department of Intervention Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
5. Department of Pediatric Surgery, Children's Hospital of Fudan University. Shanghai 201102;
6. Department of Head and Neck Tumor Surgery, School of Stomatology, Air Force Military Medical University. Xi'an 710032, Shaanxi Province;
7. Department of Aesthetic Plastic and Burn Surgery, Shandong Provincial Hospital, Shandong First Medical University. Jinan 250021,Shandong Province;
8. Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University. Jinan 250012,Shandong Province;
9. Department of Oral Surgery, School of Stomatology, Wuhan University. Wuhan 430079, Hubei Province;
10. Department of Infantile Hemangioma, Shanghai Cao'an Hospital. Shanghai 201804;
11. Department of Infantile Hemangioma, Gastrointestinal and Neonatal Surgery, Children's Hospital of Chongqing Medical University. Chongqing 400014;
12. Department of Thyroid Gland, Mammary Gland and Hemangiomas, Shandong Provincial Third Hospital. Jinan 250031, Shandong Province,China

Received:2022-06-01 Revised:2022-06-15 Online:2022-07-20 Published:2022-07-20

摘要/Abstract

摘要： 自2008年以来,普萘洛尔已经成为婴幼儿血管瘤的一线治疗药物。国内外对其治疗机制进行了大量研究,并制定和发布了多个专家共识或临床实践指南。近年来,随着临床经验的不断积累,基础研究工作的逐步深入,对血管瘤发病机制、普萘洛尔作用机制认识的不断加深,有必要对专家共识进行更新,以更加符合临床实际,指导用药和管理,为临床上使用普萘洛尔治疗婴幼儿血管瘤提供科学规范。本更新主要是简化了临床检查、用药、监测流程,使之更具有便利性和可操作性。

关键词: 普萘洛尔, 婴幼儿血管瘤, 专家共识

Abstract: Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable.

Key words: Propranolol, Infantile hemangioma, Experts consensus

中图分类号:

R739.8

郑家伟, 王绪凯, 秦中平, 范新东, 李凯, 杨耀武, 霍然, 刘少华, 赵吉宏, 汪小勇, 周德凯, 刘学键. 口服普萘洛尔治疗婴幼儿血管瘤中国专家共识（2022版）[J]. 中国口腔颌面外科杂志, 2022, 20(4): 313-319.

ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian. Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022)[J]. China J Oral Maxillofac Surg, 2022, 20(4): 313-319.

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口服普萘洛尔治疗婴幼儿血管瘤中国专家共识（2022版）

Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022)

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