Abstract: PURPOSE: To investigate the short-term clinical effect and safety of hematoporphyrine injection combined with LED-IB compound narrow spectrum photodynamic therapy in the treatment of venular malformation. METHODS: A consecutive 280 patients with venular malformation were treated from December 2011 to November 2015.Among them, 116 cases were male and 164 cases were female. Lesions of 162 patients were located at head and face, 63 cases at neck, 30 cases at limbs and 25 cases at the trunk. The size of the lesion was from 6.3 cm² to 92.0 cm², with an average size of 30.7 cm². Slow intravenous injection of hematoporphyrin (3-5 mg/kg) was performed. Immediately after the injection, LED-IB compound narrow spectrum photodynamic therapy was given for 20-35 min. The irradiation dose for children was 80 mW/cm² and 100 mW/cm² for adults. The extinctive degree of erythema and adverse reactions after treatment were recorded and analyzed. RESULTS: Two-hundred and eighty patients were treated for 504 times totally, with an average of 1.8 times. Follow-up time was 1-4 years with an average of 2.1 years. The efficacy was excellent in 204 cases, good in 62 cases and poor in 14 cases. The overall effective rate was 95%. No recurrence was found during the follow-up period. Most of the patients developed edema for 3-5 days and scab for 5-7 days. The edema in 2 cases continued for 20 days. Five cases had pigmentation, one case suffered from temporary skin photosensitivity reaction and the time of avoiding light rays exposure was for 3 months. Scars were left in 2 patients because of the thick scab and improper care. CONCLUSIONS: LED-IB compound narrow spectral photodynamic therapy for venular malformation is simple and effective. The use of photosensitizer is safe and the adverse reactions after treatment and during follow-up are rare.

Key words: LED-IB compound narrow spectrum photodynamic therapy, Hematoporphyrine injection, Venular malformations