China Journal of Oral and Maxillofacial Surgery ›› 2023, Vol. 21 ›› Issue (2): 206-208.doi: 10.19438/j.cjoms.2023.02.019

• Case Reports • Previous Articles    

Adenoid cystic carcinoma with high grade transformation and sialolithiasis of the right submandibular gland: a rare case report

HU Yong1, WANG Qiong1, ZHAO Da-yong2, YE Jin-hai3   

  1. 1. Department of Stomatology, Suzhou Science & Technology Town Hospital. Suzhou 215153;
    2. Department of Stomatology, Suzhou Kowloon Hospital, School of Medicine, Shanghai Jiao Tong University. Suzhou 215028;
    3. Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University. Nanjing 210029, Jiangsu Province, China
  • Received:2022-07-16 Revised:2022-08-11 Online:2023-03-20 Published:2023-06-12

Abstract: Adenoid cystic carcinoma(ACC) with high grade transformation(HGT) is rare, with the coexistence of a sialolith to be considered an extremely infrequent case. This article presented a case of ACC-HGT with sialolithiasis in the right submandibular gland, the poorly differentiated adenocarcinoma component of the tumor invaded the lung, spinal and brain after tumor resection, selective neck dissection and adjuvant radiotherapy and chemotherapy. The patient died twenty months after surgery due to metastases.

Key words: Adenoid cystic carcinoma, High grade transformation, Submandibular gland, Sialolithiasis

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