Adverse effects of timolol maleate 0.5% solution combined with propranolol in treating infantile hemangiomas

Abstract

Abstract: PURPOSE : To observe the adverse effects of using topical timolol maleate 0.5% solution in combination with oral propranolol and oral propranolol alone for infantile hemangiomas (IH). METHODS : A total of 60 infants with IH were included in this study, in which 30 patients were treated with topical timolol maleate 0.5% solution combined with oral propranolol and the remaining 30 cases received oral propranolol alone. All patients showed no abnormalities on physical examination before the treatment. The changes of heart rate and blood pressure were monitored before and 1h after treatment. Potential side effects such as vomiting, lethargy, diarrhea, local skin reactions, cold extremities, and hypoglycemia were observed and recorded 1-month after treatment. The data was statistically analyzed with SPSS13.0 software package. RESULTS : There was no significant difference in adverse effects between the 2 groups and the difference was not significant in heart rate and blood pressure before and 1 h after treatment. CONCLUSIONS : The adverse reactions were similar between patients receiving topical timolol maleate 0.5% solution in combination with oral propranolol and oral propranolol alone, no serious adverse events were found.

Key words: Infantile hemangioma, Timolol maleate, Propranolol, Adverse effects

CLC Number:

R739.8

WANG Jia, SHI Jing, WANG Xu-kai. Adverse effects of timolol maleate 0.5% solution combined with propranolol in treating infantile hemangiomas[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(6): 539-542.

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