China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (3): 278-284.doi: 10.19438/j.cjoms.2020.03.018

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Advances in the relationship between oral microbe and oral squamous cell carcinoma

LIU Yuan, ZHANG Ling   

  1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology& Shanghai Research Institute of Stomatology. Shanghai 200011, China
  • Received:2019-07-01 Revised:2019-09-10 Published:2020-06-18

Abstract: Oral microflora plays an important role in human microflora and human health, the imbalance between microbes and their hosts leads to oral and systemic diseases. Some tumors have been considered to be related to the existence of bacteria and other microorganisms, and the relationship between oral tumors and microorganisms has been gradually recognized. This paper reviewed the relationship between oral squamous cell carcinoma and oral microorganisms, and expounded the possible pathway of oral squamous cell carcinoma caused by oral microorganisms and the influence of oral squamous cell carcinoma microenvironment on microorganisms, in order to provide reference for further research on the relationship between oral microbe and tumor, so as to realize the purpose of early diagnosis of oral squamous cell carcinoma and even adjuvant therapy.;

Key words: Oral cavity, Squamous cell carcinoma, Microorganisms, Porphyromonas gingivalis, Candida albicans

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