Research advances of microRNA in osteogenesis regulation

Abstract

Abstract: The differentiation and function regulation of osteoblast rely on the co-operation between various hormones and cytokines which are locally produced. micro-RNAs (miRNAs) are single strand and non-coding RNAs which comprise 20 to 24 nucleotides in length. They are involved in the regulation of post-transcriptional events through combination of specific sequence on target RNA gene. Current literatures indicate that miRNAs can regulate the differentiation and proliferation of osteoblast, osteoclast and cartilage, and maintain the balance between bone formation and bone absorption. They also regulate the ossification of cartilage. Therefore, miRNAs are powerful regulators for biological organ development and some metabolic bone diseases. The discovery of miRNAs shows an important function containing in the noncoding region of genome. They are expected to provide potential gene therapy targets for clinical treatment of metabolic bone diseases and recovery of bone defect. This review summarized the current understanding and progress of microRNAs in osteogenesis regulation.

Key words: miRNA, Regulation, Osteogenesis

CLC Number:

WANG Feng, ZOU Duo-hong, WU Yi-qun. Research advances of microRNA in osteogenesis regulation[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(1): 85-89.

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