The role of glial cell line-derived neurotrophic factor (GDNF) in repair of demyelination in SD rat model with trigeminal neuralgia

Abstract

Abstract: PURPOSE: To discuss the role of glial cell line-derived neurotrophic factor (GDNF) in repair of demyelination in SD rat model with trigeminal neuralgia. METHODS: Thirty SD rat model with trigeminal neuralgia had been successfully established and were divided into the treatment group, control group and blank group. The rats were fixed on the rat brain locator after anesthesia. 10 μL 2% GDNF was injected in the left trigeminal nerve root in the treatment group. 10 μL normal saline solution was injected at the same area in the control group. Planetary astrocyte GFAP immunofluorescence staining was performed to observe the changes of astrocytes in the treatment group 、control group and bland group. SPSS 13.0 software package was used for statistical analyzed. RESULTS: 3,7,14,21,28 days after operation, rats in the treatment group was not sensitive to pain stimulus than the control group and the blank group. Keratinocyte in the treatment group was significantly reduced compared with those in control and blank group. CONCLUSIONS: Trigeminal neuralgia is associated with nerve degeneration and demyelination. GDNF can effectively participate in the regulation of pain, and may be involved in the regulation of trigeminal neuralgia by promoting repair and regeneration of nerve fibers.

Key words: Trigeminal Neuralgia, GDNF, Remyelination

CLC Number:

R745.1.1

ZHU Bing-jie, GUO Yong-feng, LI Ming-zi, ZHOU Qing. The role of glial cell line-derived neurotrophic factor (GDNF) in repair of demyelination in SD rat model with trigeminal neuralgia[J]. China Journal of Oral and Maxillofacial Surgery, 2016, 14(6): 495-498.

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