Abstract: PURPOSE: To investigate the effect of dental implant prosthesis and conventional prosthesis on the quality of life and the levels of aspartate aminotransferase (AST) and osteopontin (OPN) in gingival crevicular fluid of patients with dentition loss. METHODS: One hundred and six patients with dentition defect were prospectively selected from October 2016 to October 2018 in the Department of Stomatology, Hankou Branch of General Hospital of Central Theater Command. The patients were divided into two groups by random number table method. Patients in the experimental group (53 cases) were treated with dental implant prosthesis, while patients in the control group (53 cases) were treated with conventional prosthodontics. The curative effect, quality of life, AST and OPN levels in gingival crevicular fluid of the patients were observed. SPSS 25.0 software package was used to analyze the data. RESULTS: The total effective rate of the experimental group was 90.57%, which were significantly higher than that of the control group (P<0.05). After treatment, the AST and OPN levels in gingival crevicular fluid in the experimental group were significantly lower than those in the control group (P<0.05). After treatment, the OHIP-14 scores of the experimental group were significantly lower than those of the control group in terms of functional limitation, physiological pain, psychological discomfort, physiological disorder, psychological disorder, social disorder and disability (P<0.05). CONCLUSIONS: Dental implant prosthesis can significantly improve the quality of life of patients with dentition loss, and has little impact on the levels of AST and OPN in gingival crevicular fluid.

Key words: Implant restoration, Routine repair, Dentition loss, Quality of life, AST, OPN