富血小板纤维蛋白（PRF）联合自体骨在拔牙同期自体牙即刻移植术中的临床疗效观察

摘要/Abstract

摘要： 目的探讨富血小板纤维蛋白（platelet-rich fibrin,PRF）联合自体骨在拔牙同期自体牙即刻移植中充填牙周骨缺损的临床可行性。方法将2014年1月—2015年12月就诊行拔牙同期自体牙即刻移植的130例患者,按患者意愿及就诊顺序随机分为A、B和C 3组,在移植牙根周骨质缺损区分别填塞不同的移植材料。A组60例采用PRF联合自体骨植入;B组35例单纯植入PRF;C组35例单纯植入自体骨,随访12 个月,对术后移植牙松动度和影像学表现进行评价。采用SPSS13.0软件包对数据进行统计学分析。结果随访 12 个月,A 组成功率为80%,有效率为 96.4%;B 组成功率为51.4%,有效率为80%; C 组成功率为57.1%,有效率为77.1%;经χ²检验,A组与B组、C组间的成功率、有效率差异均有统计学意义（P<0.05）,B组与C组的成功率、有效率差异无统计学意义（P>0. 05）。结论在自体牙移植中植入PRF联合自体骨可促进牙周成骨,有利于移植牙的稳固。

关键词: 富血小板纤维蛋白, 即刻移植, 骨缺损, 自体牙

Abstract: PURPOSE: To investigate the clinical feasibility of application of platelet-rich fibrin(PRF) combined with autogenous bone grafting in the treatment of periodontal bone defect with immediate autogenous tooth transplantation. METHODS: From January 2014 to December 2015, 130 cases of immediate autogenous tooth transplantation were randomly divided into group A, B and C according to the wishes of patients and the order of treatment. Different graft materials were filled in the bone defect. In group A, 60 patients were treated with PRF combined with autogenous bone implantation; In group B, 35 patients were implanted with PRF alone. In group C, 35 patients were treated with autogenous bone graft. The patients were followed up for 12 months, the degree of teeth loosening and imaging films after operation were taken and evaluated. SPSS 13.0 software package was used for statistical analysis. RESULTS: In group A, the success rate was 80% and the effective rate was 96.4%; In group B, the success rate was 51.4%, the effective rate was 80%; In group C, the success rate was 57.1%, the effective rate was 77.1%. χ² test showed significant difference in success rate effective rate between group A and group B, group A and group C (P<0.05), but no significant difference between group B and group C (P>0.05). CONCLUSIONS: Placement of PRF combined with autogenous bone can promote periodontal osteogenesis, which is beneficial to the stability of transplanted teeth.

Key words: Platelet-rich fibrin, PRF, Immediate transplantation, Bone defect, Autogenous teeth

中图分类号:

R782.12

刘军平, 陈富广, 邝见娉. 富血小板纤维蛋白（PRF）联合自体骨在拔牙同期自体牙即刻移植术中的临床疗效观察[J]. 中国口腔颌面外科杂志, 2016, 14(6): 527-531.

LIU Jun-ping, CHEN Fu-guang, KUANG Jian-pin. Clinical study of platelet- rich fibrin (PRF) combined autogenous bone in auto-dental immediate transplantation[J]. China J Oral Maxillofac Surg, 2016, 14(6): 527-531.

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