去端肽胶原修复下颌第三磨牙拔除后邻牙远中骨缺损的自身对照研究

doi:10.19438/j.cjoms.2021.04.008

中国口腔颌面外科杂志 ›› 2021, Vol. 19 ›› Issue (4): 332-336.doi: 10.19438/j.cjoms.2021.04.008

去端肽胶原修复下颌第三磨牙拔除后邻牙远中骨缺损的自身对照研究

郭亚荣, 卢旭光, 王兴, 程永峰, 何东宁

山西医科大学口腔医学院·口腔医院,山西太原 030001

收稿日期:2021-01-22 修回日期:2021-03-10 出版日期:2021-07-20 发布日期:2021-08-05
通讯作者: 何东宁,E-mail：hdn00@163.com
作者简介:郭亚荣（1992-）,女,医师,在读硕士研究生,E-mail：qimiaog@163.com
基金资助:
山西省卫生计生委科研项目计划（2017119）

Application of atelo-collagen for distal bone defect restoration of the second molar after mandibular third molar extraction: a split-mouth clinical trial

GUO Ya-rong, LU Xu-guang, WANG Xing, CHENG Yong-feng, HE Dong-ning

Shanxi Medical University School and Hospital of Stomatology. Taiyuan 030001, Shanxi Province, China

Received:2021-01-22 Revised:2021-03-10 Online:2021-07-20 Published:2021-08-05

摘要/Abstract

摘要： 目的： 评价去端肽胶原对下颌第三磨牙拔除后邻牙远中骨缺损再生的临床效果。方法： 选择2019年1月—2019年7月就诊于山西医科大学口腔医院颌面外科的双侧下颌第三磨牙均为水平中位阻生的患者32例,采用第二磨牙颊侧龈沟内结合远中颊侧切口、不去骨的方法拔除双侧下颌第三磨牙后,随机选择一侧作为实验组,拔牙窝植入去端肽胶原;另一侧作为对照组,常规植入胶质银明胶海绵。拔牙术前、术后3个月和6个月,测量第二磨牙远中颊侧探诊深度,术后3个月、6个月拍摄锥形束CT（cone-beam CT,CBCT）,测量第二磨牙远中成骨情况。数据采用SPSS 24.0软件包进行统计学分析。结果： 去端肽胶原组和自然愈合组术后3个月和6个月第二磨牙远中牙周探诊深度较术前均有所降低,但是组间差异无统计学意义（P>0.05）;术后3个月和6个月,去端肽胶原组第二磨牙远中新生骨高度和骨密度均显著大于自然愈合组（P<0.001）;术后3个月,去端肽胶原组新生骨的体积显著大于自然愈合组（P<0.05）,但术后6个月,2组间新生骨的体积差异无统计学意义（P>0.05）。结论： 去端肽胶原有利于下颌第三磨牙拔除后第二磨牙远中骨缺损的重建和修复。

关键词: 去端肽胶原蛋白, 下颌第三磨牙, 第二磨牙, 骨缺损修复

Abstract: PURPOSE: To evaluate the clinical effect of atelo-collagen grafting on reconstruction of intrabony defects of the second molar after mandibular third molar extraction. METHODS: Thirty-two patients who had their mandibular third molars extracted at Shanxi Medical University Hospital of Stomatology from January 2019 to July 2019 were included in this study. Bilateral mandibular third molars were in horizontal position in all patients. After extraction, the same person's tooth sockets were divided into two groups: the control group and the atelo-collagen group. The tooth sockets in the control group received colloidal silver gelatin sponge, while in the atelo-collagen group atelo-collagen was used to fill the sockets. The patients were followed up for 3, 6 months. Assessments of distal buccal probing depth of the second molar and X-ray examination were performed 3, 6 months postoperatively. The data were analyzed with SPSS 24.0 software package. RESULTS: Probing depths were improved after operation in both groups. There was no significant difference between the two groups. The height and bone density of the new bone in the atelo-collagen group were significantly higher than those in the control group(P<0.001). Three months after operation, the volume of new bone in the atelo-collagen group was significantly larger than the control group. CONCLUSIONS: Atelo-collagen can promote bone regeneration and reconstruction in the intrabony defect of second molar caused by extraction of mandibular third molar.

Key words: Atelo-collagen, Mandibular third molar, Second molar, Bone defect repair

中图分类号:

R782.1

郭亚荣, 卢旭光, 王兴, 程永峰, 何东宁. 去端肽胶原修复下颌第三磨牙拔除后邻牙远中骨缺损的自身对照研究[J]. 中国口腔颌面外科杂志, 2021, 19(4): 332-336.

GUO Ya-rong, LU Xu-guang, WANG Xing, CHENG Yong-feng, HE Dong-ning. Application of atelo-collagen for distal bone defect restoration of the second molar after mandibular third molar extraction: a split-mouth clinical trial[J]. China J Oral Maxillofac Surg, 2021, 19(4): 332-336.

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去端肽胶原修复下颌第三磨牙拔除后邻牙远中骨缺损的自身对照研究

Application of atelo-collagen for distal bone defect restoration of the second molar after mandibular third molar extraction: a split-mouth clinical trial

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