3D生物打印技术在口腔颌面部骨组织缺损修复的研究进展

doi:10.19438/j.cjoms.2018.03.018

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (3): 279-283.doi: 10.19438/j.cjoms.2018.03.018

3D生物打印技术在口腔颌面部骨组织缺损修复的研究进展

陈旭卓，周知航，郑吉驷，张善勇，杨驰

上海交通大学医学院附属第九人民医院·口腔医学院口腔外科，国家口腔疾病临床研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，上海200011

收稿日期:2017-05-24 修回日期:2017-07-20 出版日期:2018-05-20 发布日期:2018-06-12
通讯作者: 张善勇，E-mail：zhangshanyong@126.com；杨驰，E-mail：yangchi63@hotmail.com。
作者简介:陈旭卓（1994-），男，硕士研究生，E-mail：cxzzxcaa@126.com
基金资助:
国家自然科学基金（81371168，81671010）；上海市科学技术委员会科技创新行动计划生物医药领域
科技支撑项目（16441908800）；上海市教育委员会高峰高原学科建设计划（20152226）

Research progress of 3D bio-printing technology in treatment of oral and maxillofacial bone defects

CHEN Xu-zhuo, ZHOU Zhi-hang, ZHENG Ji-si, ZHANG Shan-yong, Yang Chi.

Department of Oral Surgery, Shanghai Ninth People's Hospital, Collage of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center of Stomatology; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2017-05-24 Revised:2017-07-20 Online:2018-05-20 Published:2018-06-12

摘要/Abstract

摘要： [提要] 3D生物打印是基于3D打印技术的基本原理，应用计算机辅助设计技术虚拟出待构建组织器官的三维立体结构，再利用相应的生物材料，逐层构建出实体的一种组织工程学技术。3D生物打印已在再生医学领域取得了一定成果，临床应用前景广阔。在口腔颌面部缺损修复中，3D生物打印技术可通过重建缺损部位的解剖结构，应用生物材料精确堆积出个性化植入物，使组织形态和功能得以恢复。本文对3D生物打印技术的发展及类别，3D生物打印应用于口腔颌面部骨缺损修复中的生物支架材料、细胞、生物活性因子等的研究进展进行简要综述。

关键词: 3D生物打印, 组织工程, 生物支架材料, 口腔颌面部骨缺损修复

Abstract: [Summary] Based on the rationale of 3D printing, 3D bio-printing serves as a sort of tissue engineering technology, utilizing computer aided design technology to build virtual three-dimensional structure of tissues and organs, and then creates the desired entity step by step with the use of corresponding biological materials. 3D bio-printing has made several remarkable achievements in the field of regenerative medicine, with a promising prospect for clinical application. With regard to the repair of oral and maxillofacial defects, 3D bio-printing technology reconstructs the anatomical structure of defects accurately by making use of various biological composite materials to build personalized implants layer by layer. This technology increases the stability of implants and the binding rate of implants and normal tissues. As a result, both the morphology and functions of tissues are restored. Based upon the research data both at home and abroad, the history and category of 3D bio-printing technology as well as the progress and dynamic of biological materials, cells and bioactive factors applied in oral and maxillofacial bone defect repair were introduced in this review.

Key words: 3D bio-printing, Tissue engineering, Biomaterials, Oral and maxillofacial bone repair

中图分类号:

R782

陈旭卓，周知航，郑吉驷，张善勇，杨驰. 3D生物打印技术在口腔颌面部骨组织缺损修复的研究进展[J]. 中国口腔颌面外科杂志, 2018, 16(3): 279-283.

CHEN Xu-zhuo, ZHOU Zhi-hang, ZHENG Ji-si, ZHANG Shan-yong, Yang Chi.. Research progress of 3D bio-printing technology in treatment of oral and maxillofacial bone defects[J]. China J Oral Maxillofac Surg, 2018, 16(3): 279-283.

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3D生物打印技术在口腔颌面部骨组织缺损修复的研究进展

Research progress of 3D bio-printing technology in treatment of oral and maxillofacial bone defects

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