125I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤7例临床分析

doi:10.19438/j.cjoms.2023.05.012

中国口腔颌面外科杂志 ›› 2023, Vol. 21 ›› Issue (5): 497-501.doi: 10.19438/j.cjoms.2023.05.012

¹²⁵I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤7例临床分析

王守鹏^1,*, 李胜男^1,*, 陈霖^1,2, 葛良玉¹, 李梦¹, 孟箭^1,2

1.徐州市中心医院口腔科,江苏徐州 221009;
2.徐州医科大学口腔医学院,江苏徐州 221004

收稿日期:2023-02-22 修回日期:2023-03-16 出版日期:2023-09-20 发布日期:2023-10-11
通讯作者: 孟箭,E-mail: mrocket@126.com
作者简介:王守鹏（1995-）,男,硕士,住院医师,E-mail：wshoupeng@126.com;李胜男（1995-）,女,硕士,E-mail：18863661105@163.com。^*并列第一作者
基金资助:
国家口腔疾病临床医学研究中心开放课题（NCRCO-202101）; 徐州市重点研发计划（KC21187）; 徐州医科大学附属医院发展基金项目（XYFY202207）

Clinical analysis of 7 cases of ¹²⁵I radioactive seed implant for recurrent palatal minor salivary gland malignancy

WANG Shou-peng¹, LI Sheng-nan¹, CHEN Lin^1,2, GE Liang-yu¹, LI Meng¹, MENG Jian^1,2

1. Department of Stomatology, Central Hospital of Xuzhou City. Xuzhou 221009;
2. School of Stomatology, Xuzhou Medical University. Xuzhou 221004, Jiangsu Province, China

Received:2023-02-22 Revised:2023-03-16 Online:2023-09-20 Published:2023-10-11

摘要/Abstract

摘要： 目的：探讨¹²⁵I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤的临床效果。方法：对7例手术+放疗后复发且拒绝二次手术的腭部小唾液腺恶性肿瘤患者进行¹²⁵I放射性粒子植入治疗,根据患者具体情况制定治疗计划,术中将¹²⁵I放射性粒子植入设计的靶区组织间,术后视情况戴用赝复体式放射性粒子布源器。定期随访,观察治疗效果及不良反应。结果：7例患者随访17~62个月,均未见肿瘤再次复发,未出现明显3级及以上放射性损伤。随访过程中,1例高龄患者因全身疾病死亡,3例患者出现轻度暂时性不良反应。结论：对于复发的腭部小唾液腺恶性肿瘤,¹²⁵I放射性粒子植入治疗近期疗效良好,是一种安全、微创、有效的治疗方案。

关键词: 腭部恶性肿瘤, 小唾液腺肿瘤, 复发, ¹²⁵I放射性粒子, 近距离放射治疗

Abstract: PURPOSE: To explore the effect of ¹²⁵I radioactive seed implant for recurrent palatal minor salivary gland malignancy. METHODS: Seven patients with palatal minor salivary gland malignancy who relapsed after surgery and radiotherapy and refused secondary surgery were treated with iodine 125 radioactive seed implant. According to the treatment planning system, iodine 125 radioactive seeds were implanted into the target area during surgery. Prosthesis-like applicators with radioactive seeds were wore according to the patients' conditions after surgery. The patients were followed up at regular intervals after operation and the treatment efficacy and side effects were evaluated. RESULTS: Tumor recurrence was not found in any patient treated after 17 to 62 months of follow-up. All patients did not show obvious radiation-related complications of grade 3 or more. During the follow-up, 1 elderly patient died of systemic disease and temporary mild adverse effects were noted in 3 patients. CONCLUSIONS: For patients with recurrent palatal minor salivary gland malignancy, iodine 125 radioactive seed implant has achieved good short-term efficacy and is a safe, minimally invasive, and effective treatment.

Key words: Palatal malignant tumor, Minor salivary gland tumor, Relapse, Iodine 125 radioactive seed, Brachytherapy

中图分类号:

R739.8

王守鹏, 李胜男, 陈霖, 葛良玉, 李梦, 孟箭. ¹²⁵I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤7例临床分析[J]. 中国口腔颌面外科杂志, 2023, 21(5): 497-501.

WANG Shou-peng, LI Sheng-nan, CHEN Lin, GE Liang-yu, LI Meng, MENG Jian. Clinical analysis of 7 cases of ¹²⁵I radioactive seed implant for recurrent palatal minor salivary gland malignancy[J]. China J Oral Maxillofac Surg, 2023, 21(5): 497-501.

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¹²⁵I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤7例临床分析

Clinical analysis of 7 cases of ¹²⁵I radioactive seed implant for recurrent palatal minor salivary gland malignancy

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