口腔鳞状细胞癌时辰化疗中国专家共识

doi:10.19438/j.cjoms.2019.01.002

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (1): 7-12.doi: 10.19438/j.cjoms.2019.01.002

口腔鳞状细胞癌时辰化疗中国专家共识

杨凯^1#, 郭伟^2#, 孙沫逸³, 郑家伟², 李龙江⁴, 唐瞻贵⁵, 任国欣², 陈丹¹, 吕晓强¹, 张杰⁶, 韩正学⁷, 席庆⁸, 孙志军⁹, 陈晓品¹⁰, 张涛¹⁰, 车宗刚¹¹, 冉炜¹², 孟箭¹³, 黄桂林¹⁴, 唐洪¹, 肖灿¹⁵

1.重庆医科大学附属第一医院口腔颌面外科,重庆 400016;
2.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011;;
3.空军军医大学第三附属医院（第四军医大学口腔医学院）口腔颌面外科,陕西西安 710032;
4.四川大学华西口腔医学院头颈肿瘤外科,四川成都 610041;
5.中南大学湘雅口腔医学院口腔颌面外科,湖南长沙 410013;
6.北京大学口腔医学院口腔颌面外科,北京 100081;
7.首都医科大学附属北京口腔医院口腔颌面-头颈肿瘤外科,北京 100050;
8.中国人民解放军总医院第一医学中心口腔科,北京 100853;
9.武汉大学口腔医学院口腔颌面-头颈肿瘤外科,湖北武汉 430079;
10.重庆医科大学附属第一医院肿瘤科,重庆 400016;
11.淄博市中心医院口腔颌面外科,山东淄博 255036;
12.中山大学附属第一医院口腔颌面外科,广东广州 510080;
13.徐州市中心医院口腔颌面外科,江苏徐州 221009;
14.遵义医科大学附属口腔医院口腔颌面外科,贵州遵义 563000;
15.苏州大学附属第一医院口腔科,江苏苏州 215006

收稿日期:2018-11-10 修回日期:2018-12-16 出版日期:2019-01-20 发布日期:2019-02-21
通讯作者: 郭伟,E-mail:guoweicn@yahoo.com;杨凯,E-mail:cqfyyk@aliyun.com。^#共同通信作者
作者简介:杨凯（1965-）,男,教授,主任医师,博士研究生（博士后）导师

Chinese expert consensus on chrono-chemotherapy for oral squamous cell carcinoma

YANG Kai¹, GUO Wei², SUN Mo-yi³, ZHENG Jia-wei², LI Long-jiang⁴, TANG Zhan-gui⁵, REN Guo-xin², CHEN Dan¹, LV Xiao-qiang¹, ZHANG Jie⁶, HAN Zheng-xue⁷, XI Qing⁸, SUN Zhi-jun⁹, CHEN Xiao-pin¹⁰, ZHANG Tao¹⁰, CHE Zong-gang¹¹, RAN Wei¹², MENG Jian¹³, HUANG Gui-lin¹⁴, TANG Hong¹, XIAO Can¹⁵

1.Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing 400016;
2.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
3. Department of Oral and Maxillofacial Surgery, The Third Affiliated Hospital, Air Force Medical University School of Stomatology, Fourth Military Medical University. Xi'an 710032, Shaanxi Province;
4.Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University. Chengdu 610041, Sichuan Province;
5. Department of Oral and Maxillofacial Surgery, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
6.Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University. Beijing 100081;
7.Department of Oromaxillofacial Head and Neck Oncology Surgery, Beijing Stomatological Hospital, Capital Medical University. Beijing 100050;
8. Stomatological Department of 1st Medical Center, Chinese PLA General Hospital. Beijing 100853;
9.Department of Oromaxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University. Wuhan 430079, Hubei Province;
10.Department of Oncology, The First Affiliated Hospital of Chongqing Medical University. Chongqing 400016;
11.Department of Oral and Maxillofacial Surgery, Zibo Central Hospital. Zibo 255036, Shandong Province;
12. Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Sun Yat-sen University. Guangzhou 510080, Guangdong Province;
13. Department of Oral and Maxillofacial Surgery, Xuzhou Central Hospital. Xuzhou 221009, Jiangsu Province;
14.Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Zunyi Medical University. Zunyi 563000, Guizhou Province;
15.Department of Stomatology, The First Affiliated Hospital of Soochow University. Suzhou 215006, Jiangsu Province, China

Received:2018-11-10 Revised:2018-12-16 Online:2019-01-20 Published:2019-02-21

摘要/Abstract

摘要： 化疗是口腔鳞癌的主要治疗方法之一,也是口腔鳞癌综合治疗的重要组成部分。然而,化疗药物在体内既杀伤癌细胞又杀伤正常细胞的“双刃剑”作用,使其临床应用受到一定限制。基于人体昼夜节律变化规律进行的时辰化疗比常规化疗更安全和更有效已被大量研究所证实,为了推广和规范该技术的临床应用,我们组织相关专家讨论并制定了专家共识。该共识对口腔鳞癌时辰化疗的原则、药物选择、给药时间和方法等给出了规范化建议,可供临床实践参考。

关键词: 口腔鳞癌, 时辰化疗, 昼夜节律, 生物钟, 专家共识

Abstract: Chemotherapy is one of the main methods for treatment of oral squamous cell carcinoma, and it is also an important part of comprehensive treatment of oral squamous cell carcinoma. However, the "double-edged sword" effect of chemotherapeutic drugs in killing both cancer cells and normal cells in vivo has restricted its clinical application to a certain extent. Chrono-chemotherapy based on human circadian rhythm is safer and more effective than traditional chemotherapy, which has been confirmed by a large number of studies. In order to promote and standardize the clinical application of this technology, we organized relevant experts to discuss and formulate the chinese expert consensus. The consensus provides standardized suggestions on the principles, drug selection, administration time and methods of chrono-chemotherapy for oral squamous cell carcinoma, which can provide reference for clinical practice.

Key words: Oral squamous cell carcinoma, Chrono-chemotherapy, Circadian rhythm, Circadian clock, Expert consensus

中图分类号:

R739.8

杨凯, 郭伟, 孙沫逸, 郑家伟, 李龙江, 唐瞻贵, 任国欣, 陈丹, 吕晓强, 张杰, 韩正学, 席庆, 孙志军, 陈晓品, 张涛, 车宗刚, 冉炜, 孟箭, 黄桂林, 唐洪, 肖灿. 口腔鳞状细胞癌时辰化疗中国专家共识[J]. 中国口腔颌面外科杂志, 2019, 17(1): 7-12.

YANG Kai, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, LI Long-jiang, TANG Zhan-gui, REN Guo-xin, CHEN Dan, LV Xiao-qiang, ZHANG Jie, HAN Zheng-xue, XI Qing, SUN Zhi-jun, CHEN Xiao-pin, ZHANG Tao, CHE Zong-gang, RAN Wei, MENG Jian, HUANG Gui-lin, TANG Hong, XIAO Can. Chinese expert consensus on chrono-chemotherapy for oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2019, 17(1): 7-12.

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口腔鳞状细胞癌时辰化疗中国专家共识

Chinese expert consensus on chrono-chemotherapy for oral squamous cell carcinoma

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