中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (1): 28-31.doi: 10.19438/j.cjoms.2022.01.005

• 论著 • 上一篇    下一篇

口腔鳞癌腮腺淋巴结转移的临床病理特征与预后分析

李行1,*, 许飞虎2,*, 杨云博1, 韩楠男3, 阮敏3   

  1. 1.潍坊医学院 口腔医学院,山东 潍坊 261053;
    2.南通大学附属海安医院 口腔科,江苏 南通 226600;
    3.上海交通大学医学院附属第九人民医院 口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海 200011
  • 收稿日期:2021-02-19 修回日期:2021-08-03 出版日期:2022-01-20 发布日期:2022-01-20
  • 通讯作者: 阮敏,E-mail: doctorruanmin@sjtu.edu.cn
  • 作者简介:李行(1994-),男,硕士,E-mail: 1213175756@qq.com;许飞虎（1986-）,男,本科,E-mail：1072677680@qq.com。*并列第一作者
  • 基金资助:
    国家自然科学基金（82072983、81777270）; 上海市卫生健康委员会研究基金（201740186）; 上海市奉贤区临床诊疗中心建设项目[（2017）118]; 上海市奉贤区科学技术委员会科学技术发展基金（20170702）

Clinicopathological characteristics and prognostic analysis of oral squamous cell carcinoma with parotid lymph node metastasis

LI Xing1, XU Fei-hu2, YANG Yun-bo1, HAN Nan-nan3, RUAN Min3   

  1. 1. School of Stomatology, Weifang Medical University. Weifang 261053, Shandong Province;
    2. Department of Stomatology, Haian Hospital Affiliated to Nantong University. Nantong 226600, Jiangsu Province;
    3. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China
  • Received:2021-02-19 Revised:2021-08-03 Online:2022-01-20 Published:2022-01-20

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摘要： 目的: 探讨口腔鳞癌患者腮腺淋巴结转移的临床病理特征及预后影响因素。方法: 回顾性分析2003年1月—2017年12月上海交通大学医学院附属第九人民医院收治的60例伴或不伴腮腺淋巴结转移的口腔鳞癌患者的临床病理资料及影像学资料,分析其临床病理和影像学特征及其与预后的相关性。采用SPSS 23.0软件包对数据进行统计学分析。结果: 口腔鳞癌原发肿瘤T分期（P=0.022）及颈部淋巴结状况（N分期,P=0.008）与腮腺淋巴结转移密切相关;腮腺转移淋巴结多位于腮腺浅叶下极且易发生包膜外侵犯（P<0.05）。腮腺淋巴结转移与口腔鳞癌不良预后密切相关（P=0.0004）,伴有腮腺淋巴结转移的牙龈鳞癌患者的5年生存率显著高于原发于舌部的鳞癌（P=0.0427）。结论: 腮腺淋巴结转移是口腔鳞癌的不良预后因素,较高的T分期及N分期是口腔鳞癌发生腮腺淋巴结转移的重要因素。

关键词: 口腔鳞癌, 腮腺淋巴结, 转移, 预后

Abstract: PURPOSE: To investigate the clinical regularity of oral squamous cell carcinoma(OSCC) with parotid lymph node metastasis and its influence on prognosis. METHODS: A retrospective analysis of the clinicopathological data of 60 oral squamous cell carcinoma patients with or without parotid lymph node metastasis admitted to Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine from January 2003 to December 2017 was conducted. SPSS 23.0 software package was used for data analysis. RESULTS: Primary tumor T stage(P=0.022) and cervical lymph node status(N stage, P=0.008) were closely related to parotid lymph node metastasis. Parotid metastatic lymph nodes were mostly located in the lower pole of the superficial parotid gland and prone to extracellular invasion(P<0.05). Parotid gland lymph node metastasis is closely related to the prognosis of oral squamous cell carcinoma(P=0.0004), and the 5-year survival rate of gingival squamous cell carcinoma with parotid lymph node metastasis was significantly higher than that of tongue squamous cell carcinoma(P=0.0427). CONCLUSIONS: Parotid lymph node metastasis is a poor prognostic factor for oral squamous cell carcinoma. Higher T and N stages are two important factors that promote LN metastasis to parotid gland in OSCC patients.

Key words: Oral squamous cell carcinoma, Parotid lymph node, Metastasis, Prognosis

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