口腔疣状癌临床诊治专家共识

doi:10.19438/j.cjoms.2018.04.014

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (4): 362-370.doi: 10.19438/j.cjoms.2018.04.014

口腔疣状癌临床诊治专家共识

唐瞻贵^1#, 步荣发², 刘彦普³, 郭伟⁴, 孙沫逸³, 郑家伟⁴, 何悦⁴, 尚政军⁵, 吴煜农⁶, 李劲松⁷, 韩正学⁸, 田臻⁹, 张陈平⁴, 李铁军¹⁰, 钟鸣¹¹, 廖贵清¹², 沈子华¹, 黄俊辉¹³, 喻建军¹⁴, 苏彤¹⁵, 姚志刚¹³, 胡延佳¹

1.中南大学湘雅口腔医（学）院口腔颌面外科,湖南长沙 410013;
2.中国人民解放军总医院口腔颌面外科,北京 100853;
3.空军军医大学（第四军医大学）口腔医学院口腔颌面外科,陕西西安 710032;
4.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科, 上海 200011;
5.武汉大学口腔医学院口腔颌面外科,湖北武汉 430072;
6.南京医科大学附属口腔医院（江苏省口腔医院）口腔颌面外科,江苏南京 210029;
7.中山大学孙逸仙纪念医院口腔颌面外科,广东广州 510120;
8.首都医科大学附属北京口腔医院口腔颌面外科,北京 100050;
9.上海交通大学医学院附属第九人民医院·口腔医学院口腔病理科,上海 200011;
10.北京大学口腔医学院口腔病理科,北京 100081;
11.中国医科大学口腔医学院口腔病理科,辽宁沈阳 110122;
12.广州中山大学附属口腔医院口腔颌面外科,广东广州 510055;
13.中南大学湘雅口腔医（学）院口腔病理科,湖南长沙 410013;
14.湖南省肿瘤医院头颈外科,湖南长沙 410006;
15.中南大学湘雅医院口腔颌面外科,湖南长沙 410008

收稿日期:2018-03-09 修回日期:2018-03-28 出版日期:2018-07-20 发布日期:2018-08-09
通讯作者: 唐瞻贵,E-mail: tangzhangui@aliyun.com
作者简介:唐瞻贵（1964-）,男,博士,教授,主任医师,博士研究生导师
基金资助:
国家自然科学基金（81671003）; 湖南省科技计划（2014SK4006）

Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma

TANG Zhan-gui¹, BU Rong-fa², LIU Yan-pu³, GUO Wei⁴, SUN Mo-yi³, ZHENG Jia-wei⁴, HE Yue⁴, SHANG Zheng-jun⁵, WU Yu-nong⁶, LI Jin-song⁷, HAN Zheng-xue⁸, TIAN Zhen⁹, ZHANG Chen-ping⁴, LI Tie-jun¹⁰, ZHONG Ming¹¹, LIAO Gui-qing¹², SHEN Zi-hua¹, HUANG Jun-hui¹³, YU Jian-jun¹⁴, SU Tong¹⁵, YAO Zhi-gang¹³, HU Yan-jia¹

1.Department of Oral and Maxillofacial Surgery, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
2.Department of Oral and Maxillofacial Surgery, China PLA General Hospital. Beijing 100853;
3.Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University. Xi'an 710032, Shaanxi Province;
4. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
5.Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University. Wuhan 430072, Hubei Province;
6. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Nanjing Medical University. Nanjing 210029, Jiangsu Province;
7. Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province;
8. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Capital Medical University. Beijing 100050;
9.Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
10. Department of Oral Pathology, School of Stomatology, Peking University. Beijing 100081;
11. Department of Oral Pathology, School of Stomatology, China Medical University. Shenyang 110122, Liaoning Province;
12. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sun Yat sen University. Guangzhou 510055, Guangdong Province;
13. Department of Oral Pathology, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
14. Department of Head and Neck Surgery, Hunan Provincial Tumor Hospital. Changsha 410006, Hunan Province;
15. Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University. Changsha 410008, Hunan Province, China

Received:2018-03-09 Revised:2018-03-28 Online:2018-07-20 Published:2018-08-09

摘要/Abstract

摘要： 口腔疣状癌(oral verrucous carcinoma, OVC)是一种具有独特组织学改变和生物学行为,有别于口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)的恶性肿瘤,发病原因目前尚不明确。研究发现,其首次临床诊断符合率仅为35%,常被误诊为疣状增生、牙源性角化囊肿、侵袭性牙周炎和慢性颌骨骨髓炎等疾病。OVC的治疗手段和预后与OSCC不尽相同,误诊和误治严重影响患者的生存质量。制定OVC临床诊治专家共识的目的,是希望减少OVC误诊误治,提高早期诊断率、患者生存率和生活质量。

关键词: 口腔疣状癌, 临床诊治, 专家共识

Abstract: Oral verrucous carcinoma (OVC) is a malignant tumor with independent histological changes and biological behaviors different from those of oral squamous cell carcinomas (OSCC). Its etiology is still unclear. It has the first clinical diagnosis coincidence rate of only 35% and is often misdiagnosed as other oral diseases such as verrucous hyperplasia, odontogenic keratocyst, aggressive periodontitis and chronic osteomyelitis. The treatment and prognosis of OVC are different from those of OSCC. Its misdiagnosis and mistreatment seriously affect patients' quality of life. In order to reduce misdiagnosis and mistreatment of OVC and to improve its early diagnostic rate, patients' survival rate and quality of life, it is necessary to establish an expert consensus on this tumor according to the national clinical conditions.

Key words: Oral verrucous carcinoma, OVC, Clinical diagnosis and management, Expert consensus

中图分类号:

R739.8

唐瞻贵, 步荣发, 刘彦普, 郭伟, 孙沫逸, 郑家伟, 何悦, 尚政军, 吴煜农, 李劲松, 韩正学, 田臻, 张陈平, 李铁军, 钟鸣, 廖贵清, 沈子华, 黄俊辉, 喻建军, 苏彤, 姚志刚, 胡延佳. 口腔疣状癌临床诊治专家共识[J]. 中国口腔颌面外科杂志, 2018, 16(4): 362-370.

TANG Zhan-gui, BU Rong-fa, LIU Yan-pu, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, HE Yue, SHANG Zheng-jun, WU Yu-nong, LI Jin-song, HAN Zheng-xue, TIAN Zhen, ZHANG Chen-ping, LI Tie-jun, ZHONG Ming, LIAO Gui-qing, SHEN Zi-hua, HUANG Jun-hui, YU Jian-jun, SU Tong, YAO Zhi-gang, HU Yan-jia. Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma[J]. China J Oral Maxillofac Surg, 2018, 16(4): 362-370.

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口腔疣状癌临床诊治专家共识

Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma

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