Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients

doi:10.19438/j.cjoms.2017.01.016

Abstract

Abstract: PURPOSE: To evaluate the clinical curative effect of percutaneous sclerotherapy of arteriovenous malformations (AVMs) of soft tissues of the maxillofacial region using fibrin glue combined with OK-432 and bleomycin. METHODS: Thirteen patients with AVMs of the maxillofacial region (8 males and 5 females; mean age: 28.2 years, range: 16-46 years) were treated with a percutaneous injection of fibrin glue combined with OK-432 and bleomycin for 3-5 times following super-selective intra-arterial embolization (SIAE). RESULTS: All patients had significant swelling postoperatively for up to 1 week without major complications. The follow-up period ranged from 14-58 months (mean: 27.4 months). Three lesions were completely involuted, eight lesions were mostly involuted, and other two lesions were partially involuted. None of the lesions showed minimal involution or non-involution. CONCLUSIONS: Percutaneous sclerotherapy using fibrin glue combined with OK-432 and bleomycin following SIAE provides a simple, safe, and reliable alternative treatment for AVMs of soft tissues of maxillofacial region.

Key words: Arteriovenous malformation, Fibrin glue, OK-432, Bleomycin, Embolization, Maxillofacial region

CLC Number:

R782.2

QIN Ze-man, HUANG Zhi-quan, CHEN Wei-liang, ZHAO Xiao-peng, CHEN Rui. Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients[J]. China Journal of Oral and Maxillofacial Surgery, 2017, 15(1): 73-76.

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