Expression and significance of D-dimer and fibrinogen in patients with oral and maxillofacial space infection

doi:10.19438/j.cjoms.2020.05.007

Abstract

Abstract: PURPOSE: To analyze the expressions and diagnostic efficacy of plasma D-dimer (DD) and fibrinogen (FIB) in patients with oral and maxillofacial space infection(OMSI). METHODS: This was a retrospective cohort study that enrolled a sample of patients from January 2019 to September 2019. Seventy-two cases with OMSI were included in the experimental group, while 77 cases with benign neoplasm of the parotid gland were as the control group. SPSS 20.0 software package was used to analyze the levels of plasma DD, FIB, CRP and WBC before treatment in all subjects. RESULTS: Plasma DD and FIB levels in OMSI patients were significantly higher than those with non-space infections (P<0.05). Elevated DD and FIB levels were associated with prolonged hospitalizations in OMSI patients (t=4.104, P=0.002; t=2.825, P=0.006) ,and correlated with postoperative ICU (t=2.305, P=0.024; t=5.675, P=0.000), both of which were risk factors for prolonged hospitalization (P=0.006, P=0.015) and ICU monitoring (P=0.002, P=0.000). Plasma DD and FIB levels can be combined with CRP and WBC as diagnostic indicators for OMSI (DD: AUC=0.929, FIB: AUC=0.999). CONCLUSIONS: Plasma DD and FIB can be used to effectively and accurately diagnose OMSI in combination with CRP and WBC. Plasma DD and FIB levels are important indicators of prolonged hospitalizations and postoperative ICU in OMSI patients.

Key words: D-dimer, Fibrinogen, Oral and maxillofacial region, Space infection

CLC Number:

R782.3

XU Fei-fei, HUANG Lin-jian, CHU Han-wen, XU Xin. Expression and significance of D-dimer and fibrinogen in patients with oral and maxillofacial space infection[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(5): 417-420.

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