Abstract: PURPOSE：To monitor fibrinogen and D-dimer between venous malformation and no-venous malformation during perioperative period, and to explore the differences between various positions, area, depth and treatment modalities, which will contribute to diagnosis and therapy of venous malformation. METHODS：Fibrinogen and D-dimer level was detected in 82 cases preoperatively, two, five and 7 days after operations, which included 52 cases with venous malformations (group B) and 30 cases without venous malformation (group A). Venous malformation in Group B located in lower limbs (group L2, n=18),upper limbs (group L1, n=14), head and neck area (group L3, n=8), trunks (group L4, n=7), and more than two anatomic sites (group L5, n=5), respectively. There were 36 cases whose muscles were involved in group M1, and 16 cases without muscle involvement in group M2. There were 44 cases who received partial resection in group M1, and 8 cases received total resection in group M2. All body surface areas of group B were recorded. SPSS18.0 software package was used for data analysis. RESULTS: The results showed that there were significant differences between group A and B in D-dimer and fibrinogen levels around perioperative period, while differences were also seen between group M1 and M2 in D-dimer around perioperative period, but significant differences in fibrinogen level only lasted 7 days after surgery. ANOVA showed that there were significant differences in D-dimer from group L1 to group L5 preoperatively or 2 and 7 days after surgery. Fibrinogen level varied in different sites of group A. There were significant differences between group S1 and S2 in D-dimer during perioperative period, while differences were showed 5 and 7 days after surgery in fibrinogen level .Correlation analysis displayed showed that there was negative correlation between D-dimer and fibrinogen levels, while positive correlation was observed between D-dimer and body surface areas of lesions, negative correlation was found between fibrinogen level and lesion surface areas. CONCLUSIONS: Elevated level of D-dimer can be considered as an auxiliary diagnostic index of venous malformation. Postoperative elevation of D-dimer is seen more often in patients with venous malformations located in more than two anatomic sites or deep muscle involvement, which can lead to functional disorder of blood coagulation because of secondary decrease in fibrinogen, so that operation should be chosen carefully in these patients.

Key words: D-dimer, Venous malformation, Fibrinogen