Age-related changes of mandibular condylar cartilage: A histomorphometric study in rabbit temporomandibular joint

Abstract

Abstract: PURPOSE: To study the age-related changes of the condylar cartilage in rabbit temporomandibular joint. METHODS: Three New Zealand rabbit were obtained at the ages of 1, 4, 12 and 32 weeks, respectively. Each specimen was subjected to histolgical assessment about each layer of fibrocartilage thickness. One-way ANOVA as performed using SPSS19.0 software package. RESULTS: The decrease of the total cartilage thickness (P=0.008), the mature layer (P=0.008) and the hypertrophic layer (P=0.007) occurred from 1 to 4 weeks, and there were no significant changes within 4-32 weeks. The changes of fibrous layer and proliferative layer thickness were not significant between 1-4 weeks, 4-12 weeks, 12-32 weeks. However, the thickness of fibrous layer was significantly greater at 32-week than at 1-week (P=0.024). CONCLUSIONS: The thickness of condylar cartilage, mature layer and hypertrophic layer decreased remarkably during 1-4 week. This period is the most important stage for mandibular in growth and development. The adulthood mandibular condyle might have a stronger adaptive capacity to alteration of pressure microenvironment in temporomandibular joint.

Key words: Rabbit, Mandible, Condylar cartilage, Growth

CLC Number:

R782.4

HUANG Lin-jian, CAI Xie-yi, LI Hui, SHENG Xia-han, YANG Chi. Age-related changes of mandibular condylar cartilage: A histomorphometric study in rabbit temporomandibular joint[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(3): 200-204.

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