Research progress on tumor neurogenesis

China Journal of Oral and Maxillofacial Surgery ›› 2015, Vol. 13 ›› Issue (1): 90-93.

• Review Article • Previous Articles Next Articles

Research progress on tumor neurogenesis

LU Wei, JI Tong

Department of Oromaxillofacial Head and Neck Oncology, Ninth People′s Hospital, College of Stomatology, Shanghai Jiao Tong University school of Medicine Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2014-05-08 Online:2015-02-10 Published:2015-03-12
About author:Supported by Medical and Engineering Cross Research Fund of Shanghai Jiao Tong University (YG2011MS58)
Supported by:
上海交通大学医工交叉研究基金（YG2011MS58）

Abstract

Abstract: The reason why few studies have been made on "neurogenesis in tumors" was based on the old-fashioned notion that tumors were not able to induce growth of fresh nerve fibers. However, it now attracts huge interests among researchers as new evidence gradually emerged in recent years. The hypothesis is presented as follows: as we all know, nerve fibers accompany blood vessels and lymphatic vessels all over the human body. Since an extensive amount of knowledge has been obtained with regard to increased angiogenesis and lymph angiogenesis within tumors, chances are that there also exists neurogenesis as well. The mutual relationships and specific functions between new nerve fibers and tumors have also been wildly contemplated by some scholars. This review was intended to discuss the current understanding of this topic and some novel findings.

Key words: Neoneurogenesis, Tumor microenvironment, Neuro-neoplastic synapse

CLC Number:

R739.8

LU Wei, JI Tong. Research progress on tumor neurogenesis[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(1): 90-93.

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Research progress on tumor neurogenesis

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