Abstract: PURPOSE: The clinical characteristics and relevant examinations of bisphosphonate related osteonecrosis of the jaw（BRONJ）were analyzed in order to provide a basis for clinical prevention. METHODS: Retrospective analysis of 16 patients diagnosed with BRONJ in the First Affiliated Hospital of Xinjiang Medical University and Xinjiang Uygur Autonomous Region People's Hospital from 2013 to 2019, including general data, laboratory and imaging examination was performed. SPSS 24.0 software package was used for statistical analysis of the data. RESULTS: Among 16 patients, there were 6 males (37.5%) and 10 females(62.5%). There were primary tumors in 15 patients and osteoporosis in 1 patient. Among them, 4(25%) patients used bisphosphonates (BPs) for less than twelve months, 8(50%) patients for 12-36 months, and 4(25%) patients used bisphosphonates (BPs) for more than or equal to 36 months. Sixteen patients were at stage Ⅱ or Ⅲ. There was a significant difference between the time of using BPs and BRONJ stages(P<0.05). There was no significant difference between the time to visit for clinical symptoms after using BPs and the stage of BROBJ, and the time between the use of BPs and the laboratory test results(P>0.05). Bone mineral density measurement showed that bone density of BPs group in both regions was significantly higher than suppurative jaw osteomyelitis group and the healthy controls(P<0.05). There was no significant difference in bone mineral density between healthy group and suppurative jaw osteomyelitis group (P>0.05). CONCLUSIONS: The results suggest that the longer the time of using BPs, the more severe the BRONJ infection. Bone mineral density increased significantly after the use of BPs, and osteonecrosis of jaw bone was more likely to occur.

Key words: Bisphosphonate, Oteomyelitis of jaw, Suppurative jaw osteomyelitis