China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (6): 521-525.doi: 10.19438/j.cjoms.2020.06.010

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Effect of chemohyperthermia on nitric oxide and T lymphocyte in patients with oral and maxillofacial cancers

LIU Ying1, LI Chen-xi2, WANG Bing1, GONG Zhong-cheng1   

  1. 1. Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Autonomous Region. Urumqi 830054, Xinjiang Autonomous Region, China;
    2. Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, The Head and Neurocenter, University Medical Center Hamburg-Eppendorf UKE. Hamburg 20246, Germany
  • Received:2020-02-11 Revised:2020-05-24 Online:2020-11-20 Published:2020-12-31

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Abstract: PURPOSE: To study the effects of chemohyperthermia on nitric oxide (NO) and T lymphocyte in patients with oral and maxillofacial cancers. METHODS: Sixty patients with oral and maxillofacial cancers admitted to University Cancer Center Hamburg (UCCH) from December 2017 to December 2019 were randomly divided into thermochemotherapy group(n=30) and conventional chemotherapy group(n=30) according to a random number table method. Patients in the conventional chemotherapy group were given intravenous chemotherapy alone, while patients in the thermochemotherapy group were given thermochemotherapy on the basis of intravenous chemotherapy. The therapeutic effect, NO, T lymphocyte, quality of life along with toxic and side effects of the two groups were compared. Statistical analysis of all data was performed using SPSS 22.0 software package. RESULTS: The effective rate of treatment and disease control rate in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. After treatment, the content of NO in the conventional chemotherapy group was significantly lower than that in the thermochemotherapy group. CD4+,CD4+/CD8+ in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. The functional indexes such as physical function, emotional function, social function and comprehensive quality of life scores in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. The symptom indexes such as fatigue, pain and constipation in the thermochemotherapy group were significantly lower than those in the conventional chemotherapy group (P<0.05). There was no significant difference in toxic and side effects between the two groups (P>0.05). CONCLUSIONS: Chemohyperthermia can improve the therapeutic effect and NO content of patients with oral and maxillofacial cancer, improve the immune function of patients, enhance the quality of life of patients, and has higher safety.

Key words: Chemohyperthermia, Nitric oxide, T lymphocyte, Oral and maxillofacial cancer, Immunologic function

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