A novel staging system and corresponding therapeutic strategies for medication-related osteonecrosis of the jaw

doi:10.19438/j.cjoms.2020.06.006

China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (6): 501-507.doi: 10.19438/j.cjoms.2020.06.006

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A novel staging system and corresponding therapeutic strategies for medication-related osteonecrosis of the jaw

LIU Zhong-long, JIANG Jun-jian, LI Xiao-guang, ZHU Feng-shuo, TANG Xiao, ZHU Ling, HE Yue

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2020-03-09 Revised:2020-07-25 Published:2020-12-31

Abstract

Abstract: PURPOSE: To propose a new clinical staging method that can be performed to guide the diagnosis and treatment of MRONJ through a retrospective study of patients with medication-related osteonecrosis of the jaw (MRONJ). METHODS: The clinical data of 74 MRONJ patients admitted to Shanghai Ninth People's Hospital between 2008 and 2018 were enrolled. A novel staging method and corresponding treatments were proposed on the basis of anatomic structures (inferior alveolar canal and floor of maxillary sinus) and boundary of bone lesions. RESULTS: A new staging system with four different stages (stage 0: 7 cases; stageⅠa: 18 cases; stageⅠb: 14 cases; stage Ⅱa: 12 cases; stage Ⅱb: 15 cases; and stage Ⅲ: 8 cases) was proposed. Outcome of these samples demonstrated that only 12 cases hold progressed state. CONCLUSIONS: This new staging system is suitable for clinical diagnosis and therapeutic selection for MRONJ.

Key words: Medication-related osteonecrosis of the jaw, Clinical staging, Therapeutic strategy

CLC Number:

R739.8

LIU Zhong-long, JIANG Jun-jian, LI Xiao-guang, ZHU Feng-shuo, TANG Xiao, ZHU Ling, HE Yue. A novel staging system and corresponding therapeutic strategies for medication-related osteonecrosis of the jaw[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(6): 501-507.

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A novel staging system and corresponding therapeutic strategies for medication-related osteonecrosis of the jaw

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