Abstract: PURPOSE: To evaluate the effect of preoperative antibiotic application on the effect of dental implantation in patients with good controlled blood glucose and mild poor controlled type 2 diabetes mellitus (T2DM), and to study the necessity of preoperative prophylactic use of antibiotics. METHODS: According to the inclusion criteria of this study, we reviewed T2DM patients with good controlled and mildly poor controlled T2DM, who received dental implant from May 2014 to May 2016. The patients were followed regularlly, then clinical examination and radiographic evaluation were carried out. The differences between groups were analyzed by t test and Chi-square test respectively with SPSS 20.0 software package. Kaplan-Meier method was used to calculate survival rate. RESULTS: A total of 57 T2DM patients were included in this retrospect study, including 30 patients in the group with good blood glucose control (13 patients with medication, 17 patients without medication), 27 patients in the group with mild poorly blood glucose control(15 patients with medication, 12 patients without medication). The wounds healed well and no infection was found in all patients. During the follow-up period, there was no significant difference in implant survival rate, bleeding on probing%, modified plaque index, periimplant probing depth and marginal bone loss. CONCLUSIONS: Prophylactic use of antibiotics before dental implantation surgery can not improve wound healing, long-term survival rate and marginal bone loss. There is a lack of evidence to support the necessity of systemic antibiotic prophylaxis in T2DM patients with good and mild poorly controlled blood glucose.

Key words: Dental implants, Type 2 diabetes mellitus, Antibiotics