Detection and analysis of immune function in children with juvenile recurrent parotitis

doi:10.19438/j.cjoms.2019.02.005

Abstract

Abstract: PURPOSE: Juvenile recurrent parotitis(JRP) is defined as recurrent parotid inflammation occurring in children, usually associated with non-obstructive sialectasis of the parotid gland. The etiology of JRP remains unclear, probably immunologically mediated. The purpose of the present study was to investigate the relationship between JRP and immune function based on the measurement of immunoglobulins and T-lymphocyte subset of JRP patients. METHODS: We retrospectively studied the clinical data of 100 JRP children and 100 healthy controls. All the subjects underwent clinical examination of salivary glands as well as immune function detection during the intermission of JRP and necessary radiological examination. We established a database recording demographic and clinical characteristics, medical history, immune function results, etc for each subject. SPSS 23.0 software package was used for statistical analysis. Comparison of means between two groups was performed with independent samples Student's t test. RESULTS: Serum IgG and IgM levels were significantly higher in JRP children than in normal children between 2-6 years (P<0.01). Serum IgE and IgA levels were significantly higher in JRP children than in normal children in all age strata (P<0.01), and tended to increase with age. Serum IgM levers were significantly higher in JRP children than in normal children aged<6 (P<0.05). CD4+ levels were higher in normal children than in JRP children in all age strata (P<0.01). CD8+ levels were higher in JRP children than in normal children in all age strata(P<0.01). CONCLUSIONS: Immune function derangement and anaphylaxis may be involved in the process of JRP.

Key words: Juvenile recurrent parotitis, Immune function, Humoral immunity, Cellular immunity

CLC Number:

R781.7

WANG Zhi-jun, WU Shu-feng, YU Chuang-qi, XIE Li-song, SHI Huan, CAO Ning-ning, ZHENG Ling-yan. Detection and analysis of immune function in children with juvenile recurrent parotitis[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(2): 123-128.

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