Abstract: [Summary] Based on the rationale of 3D printing, 3D bio-printing serves as a sort of tissue engineering technology, utilizing computer aided design technology to build virtual three-dimensional structure of tissues and organs, and then creates the desired entity step by step with the use of corresponding biological materials. 3D bio-printing has made several remarkable achievements in the field of regenerative medicine, with a promising prospect for clinical application. With regard to the repair of oral and maxillofacial defects, 3D bio-printing technology reconstructs the anatomical structure of defects accurately by making use of various biological composite materials to build personalized implants layer by layer. This technology increases the stability of implants and the binding rate of implants and normal tissues. As a result, both the morphology and functions of tissues are restored. Based upon the research data both at home and abroad, the history and category of 3D bio-printing technology as well as the progress and dynamic of biological materials, cells and bioactive factors applied in oral and maxillofacial bone defect repair were introduced in this review.

Key words: 3D bio-printing, Tissue engineering, Biomaterials, Oral and maxillofacial bone repair