TPF诱导化疗联合术后放疗治疗口腔鳞癌的疗效及对ING4、Annexin A1的影响

doi:10.19438/j.cjoms.2018.05.010

摘要/Abstract

摘要： 目的: 观察TPF诱导化疗联合术后放疗治疗口腔鳞癌的临床疗效,及其对ING4、Annexin A1的影响。方法: 选择2013年6月—2015年6月收治的口腔鳞癌患者146例,按照随机数字表法分为观察组和对照组,每组各73例。观察组给予TPF诱导化疗+手术切除+术后放疗,对照组给予手术切除加术后放疗。比较2组患者的临床疗效,检测治疗前、后2组患者ING4和Annexin A1的表达水平,记录2组患者不良反应的发生率和1年、2年生存率。采用SPSS 19.0软件包对数据进行统计学分析。结果: 观察组和对照组的总缓解率分别为88.41%和58.57%,观察组的总缓解率显著高于对照组（χ²=23.690,P=0.000）。治疗前,2组患者ING4的阳性表达率和Annexin A1相对表达水平相当（P>0.05）。治疗后,2组患者的ING4的阳性表达率均显著升高,Annexin A1相对表达水平均下降,但观察组的改变幅度显著高于对照组（P<0.05）。观察组的1年及2年生存率均显著高于对照组（P<0.05）。观察组的恶心、呕吐、口腔黏膜受损、白细胞降低及放射性皮疹等不良反应发生率均显著高于对照组（P<0.05）。结论: TPF诱导化疗联合术后放疗治疗口腔鳞癌能够有效提高临床疗效和短期生存率,其作用通过升高ING4表达水平、降低Annexin A1表达水平,促进细胞凋亡而实现。

关键词: 口腔鳞癌, TPF诱导化疗, 术后放疗, ING4, Annexin A1

Abstract: PURPOSE: To observe the clinical effect of TPF induced chemotherapy combined with postoperative radiotherapy on oral squamous cell carcinoma (OSCC) and its impact on expression of ING4 and Annexin A1. METHODS: A total of 146 patients with oral squamous cell carcinoma (OSCC) treated from June 2013 to June 2015 in our hospital were selected. According to random digital table, the patients were divided into observation group and control group with 73 cases in each group. Patients in observation group were treated with TPF induced chemotherapy and postoperative radiotherapy; while patients in the control group were treated with surgical resection plus postoperative radiotherapy. The clinical efficacy of the two groups was observed and compared. The expression of ING4 and Annexin A1 in the two groups before and after treatment was detected. The incidence of adverse reactions, 1- and 2-year survival rates were recorded and compared between the two groups. SPSS19.0 software package was used for statistical analysis. RESULTS: The total remission rates of the observation group and the control group were 88.41% and 58.57%, respectively. The total remission rate of the observation group was significantly higher than that of the control group (χ²=23.690, P=0.000). Before treatment, the positive expression rate of ING4 and the relative expression level of Annexin A1 were similar between the two groups (P>0.05). After treatment, the positive expression rate of ING4 in the observation group was significantly higher than that of the control group (P<0.05), and the relative expression level of Annexin A1 in the observation group was significantly lower than that of the control group (P<0.05). The 1- and 2-year survival rates in the observation group were significantly higher than those in the control group (P<0.05). The incidence of nausea, vomiting, oral mucosa damage, leucopenia and radionuclide rash in the observation group were significantly higher than those in the control group (P<0.05). CONCLUSIONS: TPF induced chemotherapy combined with postoperative radiotherapy can effectively improve the clinical efficacy and short-term survival rate of patients with oral squamous cell carcinoma. The possible mechanisms involved increasing the expression of ING4, reducing the expression of Annexin A1 and promoting apoptosis.

Key words: Oral squamous cell carcinoma, TPF induced chemotherapy, Postoperative radiotherapy, ING4, Annexin A1

中图分类号:

R739.8

李怀奇, 武和明, 丁旭, 叶金海, 吴煜农. TPF诱导化疗联合术后放疗治疗口腔鳞癌的疗效及对ING4、Annexin A1的影响[J]. 中国口腔颌面外科杂志, 2018, 16(5): 436-440.

LI Huai-qi, WU He-ming, DING Xu, YE Jin-hai, WU Yu-nong. Effect of TPF induced chemotherapy combined with postoperative radiotherapy on oral squamous cell carcinoma and its impact on expression of ING4 and Annexin A1[J]. China J Oral Maxillofac Surg, 2018, 16(5): 436-440.

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