基于3D打印水凝胶技术的显微外科仿真训练教具的研制与应用效果评价

doi:10.19438/j.cjoms.2021.06.014

中国口腔颌面外科杂志 ›› 2021, Vol. 19 ›› Issue (6): 557-561.doi: 10.19438/j.cjoms.2021.06.014

基于3D打印水凝胶技术的显微外科仿真训练教具的研制与应用效果评价

杨勇¹, 丁明超¹, 杨涛², 刘义闻¹, 陆金标¹, 田磊¹

1. 空军军医大学口腔医院颌面创伤与正颌外科,军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病国际联合研究中心,空军军医大学口腔医学院,陕西西安 710032;
2. 空军军医大学口腔医院头颈肿瘤外科,陕西西安 710032

出版日期:2021-12-25 发布日期:2022-03-02
通讯作者: 田磊,E-mail：tianleison@163.com
作者简介:杨勇（1984-），男，硕士，主治医师，E-mail:383988859@qq.com
基金资助:
国家重点研发计划（NO.2018YFB1107100）; 第四军医大学口腔医院教学科研项目（2019KQJYYJ-TIANLEI）

Development and application of a novel microsurgery training tool based on 3D printed hydrogel

YANG Yong¹, DING Ming-chao¹, YANG Tao², LIU Yi-wen¹, LU Jin-biao¹, TIAN Lei¹

1. Department of Maxillofacial Trauma, Orthognathic Surgery, State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, School of Stomatology, Air Force Military Medical University. Xi'an710032;
2. Department of Head, Neck Tumor Surgery, School of Stomatology, Air Force Military Medical University. Xi’an71003, Shaanxi Province, China

Online:2021-12-25 Published:2022-03-02

摘要/Abstract

摘要： 目的采用3D打印水凝胶技术制作微小仿真血管,以此为基础,研发一种显微外科训练教具,并评估其教学效果和适用性。方法利用3D打印水凝胶技术制作微小血管,设计管路连接系统、血液循环泵等部件,研制出显微外科仿真训练教具。从空军军医大学口腔医院口腔颌面外科选择10名具有丰富显微外科经验的教师,试用新教具,通过问卷打分形式评价其与传统显微外科训练教具之间的差别。选择24名口腔医学专业第五年实习学生,随机分为对照组和实验组,每组12人,对照组学员用传统的橡皮片、软质胶管为教具进行训练,实验组学员用新教具进行训练,共训练10 d,2 h/d;训练结束后,2组学员均以吻合小鼠颈动脉进行考核打分。通过问卷调查、考核成绩评估教具使用的实用性与教学效果。采用SPSS 19.0软件包对数据进行统计学处理。结果成功研发出一套以3D打印水凝胶血管为核心,带有液体循环系统的新型显微外科训练教具。对10名教师的问卷结果显示,新教具在实用性、科学性方面优于传统教具,实验组学员的考核成绩显著高于对照组（P<0.05）。结论基于3D打印水凝胶血管技术研发的仿真显微外科训练教具实用性强、成本低,教学效果优于传统教学模式,值得推广应用。

关键词: 3D打印, 水凝胶血管, 显微外科, 临床教学

Abstract: PURPOSE: To develop a novel microsurgical training tool based on 3D printed hydrogel and evaluate its practicality and teaching effectiveness. METHODS: A series of micro-vessels were designed and produced with hydrogel by 3D printing technology and were loaded into a piping connection system with pump and other components to compose a set of microsurgical training tool; then 10 senior microsurgeons who had rich clinical teaching experience in microsurgery were selected to evaluate the differences between this new teaching aid and the traditional teaching instruments by questionnaire. Another 24 interns who were in the 5th year program of stomatology were randomly divided into the control group and the experimental group. The interns in the control group were trained for anastomosis skill twice a day by traditional instrument for 10 days, while the interns in experimental group were trained by the novel teaching tool. Then the two groups of students were given a test of microsurgery skill by doing anastomosis with rat carotid artery. Each intern's capacity of microsurgery was scored to compare the effectiveness of this novel teaching tool with the traditional one. The data were analyzed with SPSS 19.0 software package. RESULTS: A set of novel microsurgery training aid with 3D printed hydrogel blood vessels as the core was developed. The questionnaire results of 10 senior microsurgeons showed that this new teaching aid was more practical, scientific and effective than the traditional one. The score of the interns in the experimental group was significantly higher than that of the control group (P< 0.05). CONCLUSIONS: This set of teaching aid for microsurgery based on 3D printing hydrogel vascular technology is highly practical, scientific in design, convenient in use and economic in cost. Its effect in actual clinical teaching practice of microsurgery is obviously better than the traditional teaching model, indicating that this novel teaching aid is convenient for standardized training and worthy of wide application.

Key words: 3D printing, Hydrogel vessels, Microsurgery, Clinical teaching

中图分类号:

G642

杨勇, 丁明超, 杨涛, 刘义闻, 陆金标, 田磊. 基于3D打印水凝胶技术的显微外科仿真训练教具的研制与应用效果评价[J]. 中国口腔颌面外科杂志, 2021, 19(6): 557-561.

YANG Yong, DING Ming-chao, YANG Tao, LIU Yi-wen, LU Jin-biao, TIAN Lei. Development and application of a novel microsurgery training tool based on 3D printed hydrogel[J]. China J Oral Maxillofac Surg, 2021, 19(6): 557-561.

参考文献

[1] Sigaux N, Pourchet L, Breton P, et al.3D bioprinting: principles, fantasies and prospects[J]. J Stomatol Oral Maxillofac Surg, 2019, 120(2): 128-132.
[2] Katkar AR, Taft MR, Grant TG.3D volume rendering and 3D printing (additive manufacturing)[J]. Dent Clin North Am, 2018, 62(3): 393-402.
[3] Wang D, Xu Y, Li Q, et al.Artificial small-diameter blood vessels: materials, fabrication, surface modification, mechanical properties, and bioactive functionalities[J]. J Mater Chem B, 2020, 8(9): 1801-1822.
[4] Sasmal P, Datta P, Wu Y, et al. 3D bioprinting for modelling vasculature[J]. Microphysiol Syst, 2018, 2: 9.e1-9.e9.
[5] Papaioannou GT, Manolesou D, Dimakakos E, et al.3D bioprinting methods and techniques: applications on artificial blood vessel fabrication[J]. Acta Cardiol Sin, 2019, 35(3): 284-289.
[6] Yen MD, Arroyo R, Berezniak R, et al.New model for microsurgical training and skills maintenance[J]. Microsurgery, 1995, 16(11): 760-762.
[7] Chan YW, Matteucci P, Southern JS.Validation of microsurgical models in microsurgery training and competence: a review[J]. Microsurgery, 2007, 27(5): 494-499.
[8] Oltean M, Sassu P, Hellström M, et al.The microsurgical training programme in Gothenburg, Sweden: early experiences[J]. J Plast Surg Hand Surg, 2017, 51(3): 193-198.
[9] Evgeniou E, Walker H, Gujral S.The role of simulation in microsurgical training[J]. J Surg Educ, 2018, 75(1): 171-181.
[10] Altunrende EM, Hamamcioglu KM, Hicdonmez T, et al.Microsurgical training model for residents to approach to the orbit and the optic nerve in fresh cadaveric sheep cranium[J]. J Neurosci Rural Pract, 2014, 5(2): 151-154.
[11] Chua KC, Yeong YW, An J.3D printing and bioprinting in MEMS technology[J]. Micromachines(Basel), 2017, 8(7): 229-231.
[12] Gungor-Ozkerim SP, Inci I, Zhang SY, et al.Bioinks for 3D bioprinting: an overview[J]. Biomater Sci, 2018, 6(5): 915-946.
[13] Li S, Tian X, Fan J, et al.Chitosans for tissue repair and organ three-dimensional (3D) bioprinting[J]. Micromachines (Basel), 2019, 10(11): 765-794.
[14] Hangge P, Pershad Y, Witting AA, et al.Three-dimensional (3D) printing and its applications for aortic diseases[J]. Cardiovasc Diagn Ther, 2018, 8(Suppl 1): S19-S25.

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基于3D打印水凝胶技术的显微外科仿真训练教具的研制与应用效果评价

Development and application of a novel microsurgery training tool based on 3D printed hydrogel

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