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20 July 2018, Volume 16 Issue 4 Previous Issue    Next Issue

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Study on miR-181a inhibiting epithelial-mesenchymal transition and drug-resistance by targeting Twist1 in tongue squamous cell carcinoma LIU Mo, LI Jin-song, RUAN Yi, HUANG Hong-zhang 2018, 16 (4):  289-295.  doi: 10.19438/j.cjoms.2018.04.001 Abstract ( 299 )   PURPOSE:The aim of this study was to investigate the mechanism of miR-181a regulating epithelial-mesenchymal transition (EMT) and enhancing the capacity of cisplatin-resistance of tongue squamous cell carcinoma cells. METHODS: TSCC CDDP resistant cell line CAL27/CDDP and its parent cell line CAL27 were transfected with miR-181a mimics and miR-181a LNA respectively. Western blot and immunofluorescence staining were used to detect the expression of E-cadherin and Vimentin; Western blot was used to detect the expression of Twist1 and Slug; Transwell assay and scratch test were used to detect the invasion and migration capabilities; MTT was used to analyze the half maximal inhibitory concentration (IC50) values. Bioinformatics analysis was performed and found that Twist1 was directly targeted by miR-181a. Luciferase reporter gene plasmids were constructed and designed obligos including miR-181a targeting site. Dual luciferase reporter gene array was performed. SPSS17.0 software package was used to analyze the results. RESULTS: miR-181a mimics transfection reversed the EMT phenotype of CAL27/CDDP. The expression of E-cadherin was up-regulated and the expression of Vimentin, Twist1 and Slug was down-regulated. The motility was significantly decreased. IC50 of CAL27/CDDP decreased by 47.57%±6.23% (P<0.05). miR-181a LNA transfection induced EMT in CAL27. The expression of E-cadherin was down-regulated and the expression of Vimentin, Twist1 and Slug was up-regulated. The motility was significantly increased. IC50 of CAL27 increased by 55.61%±7.20%(P<0.05).CONCLUSIONS: MiR-181a inhibits EMT and CDDP drug-resistance by directly targeting Twist1 in TSCC. References | Related Articles | Metrics

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Axitinib inhibits oral mucosal melanoma growth through modulating vasculogenic mimicry in a patient-derived xenograft model HONG Duo, GU Zi-yue, LI Jiang, ZHANG Zhi-yuan 2018, 16 (4):  296-301.  doi: 10.19438/j.cjoms.2018.04.002 Abstract ( 442 )   PURPOSE:To investigate the potential application of axitinib in treatment of oral mucosal melanoma (OMM). METHODS: After successful establishment of oral mucosal melanoma-bearing patient derived xenografts (PDX) model, 16 nude mice were randomly divided into control and experimental group. After oral administration of axitinib or sodium carboxymethylcellulose for 28 days, the tumors were assessed for histological and molecular features by immunochemical assay as well as growth status at least twice a week using vernier caliper. Vasculogenic mimicry was evaluated by immunochemistry and periodic acid schiff reaction (PAS) histochemical double-staining. SPSS 23.0 software package was used for statistical analysis. RESULTS: Compared to the control group, tumor volume, amount of vasculogenic mimicry and CD34-positive vessels in the axitinib group were significantly decreased after oral administration (P<0.05); meanwhile, the protein level of EphA2 and MMP-2 was significantly decreased in the axitinib group, and the expression of HIF-1a was significantly higher than the control group(P<0.05). CONCLUSIONS: Axitinib could be applied in target treatment of OMM. References | Related Articles | Metrics

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Impact of MicroRNA-103-3p on osteogenic differentiation of MC3T3-E1 at an early stage LU Chen-pei, LI Hong-liang, OUYANG Ning-juan, LIN Yu-heng, SI Jia-wen, SHEN Guo-fang 2018, 16 (4):  302-309.  doi: 10.19438/j.cjoms.2018.04.003 Abstract ( 353 )   PURPOSE:To investigate the effect of miR-103-3p on osteogenic differentiation of MC3T3-E1 cells at an early stage. METHODS: Osteogenic differentiation of MC3T3-E1 was induced in osteoblast induction medium. Runx2, Osx, ALP, miR-103-3p mRNA expression was detected by real-time PCR at day 0, 3, 5 and 7 following induction; Western blotting was conducted to show Runx2, Osx protein expression. Osteoblastic phenotype was estimated by alkaline phosphatase (ALP) staining. miR-103-3p mimics and mimics negative control were separately transiently transfected to MC3T3-E1 cells with lipofectamine 2000. The expression of miR-103-3p was determined by real-time PCR. Cell proliferation was detected by CCK-8 kit. The transfected MC3T3-E1 cells were induced into osteogenic differentiation. Real-time PCR was conducted to detect the levels of osteogenesis-related genes, such as Runx2, Osx and ALP. Western blotting was performed to confirm their expression on protein level at day 0, 3 and 7 following induction. ALP activity was shown by ALP staining. The data were analyzed by SPSS 19.0 software package. RESULTS: mRNA expression levels of Runx2, Osx and ALP were increasingly up-regulated in MC3T3-E1 with osteogenic induction. Protein expression levels of Runx2 and Osx were consistent with mRNA expression trends. miR-103-3p was suppressed during osteogenic differentiation of MC3T3-E1. After transient transfection of miR-103-3p mimics, the expression of miR-103-3p in the experimental group was significantly up-regulated (P<0.05). Cell proliferation was decreased. mRNA expression of Runx2 and ALP was markedly down-regulated (P<0.05). Runx2 protein expression was suppressed. After osteogenic induction for 3 and 7 days, the expression of Runx2, Osx and ALP on mRNA level was markedly down-regulated in the experimental group and so was the expression on protein level. CONCLUSIONS: miR-103-3p might suppress osteogenic differentiation of MC3T3-E1 cell at an early stage. References | Related Articles | Metrics

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Effect of HER2 gene on cell proliferation, cell cycle and apoptosis in salivary malignant pleomorphic adenoma XIA Liang, WANG Yang, HU Yu-hua, WANG Li-zhen, GU Ting, LI Jiang, TIAN Zhen 2018, 16 (4):  310-316.  doi: 10.19438/j.cjoms.2018.04.004 Abstract ( 281 )   PURPOSE:To inhibit HER2 in salivary malignant pleomorphic adenoma, investigate the effect on tumor cell proliferation, cell cycle and apoptosis, and assess the possibility of blocking HER2 to improve MPA malignant biological behavior. METHODS: HER2 expression and proliferation were detected in MPA cell lines. The effect on tumor cell proliferation, cell cycle, apoptosis and down-stream pathway were verified after use of HER2 blockade. SPSS 16.0 software package was used for statistical analysis. RESULTS: HER2 overexpressed/proliferated in SM-AP1 and SM-AP4 cells. By blocking HER2, tumor proliferation and cell cycle were significantly induced, and apoptosis process was activated. In addition, the downstream pathway PI3K/Akt and MAPK/ERK were significantly inhibited. CONCLUSIONS: HER2 overexpressed/proliferated in MPA cell line, which might play an important role in tumor genesis. Inhibiting HER2 might be a novel therapy for poor biological behavior on MPA. References | Related Articles | Metrics

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Osteogenesis effect of maxillary sinus floor lift in Beagle dogs ZHANG Yao-sheng, ZHOU Zhi-hang, WANG Ye-xin, ZHANG Shan-yong, ZHENG Ji-si, YANG Chi, WANG Yong, ZHU Ying-chao, HUANG Hui, ZHANG Yong-ya 2018, 16 (4):  317-321.  doi: 10.19438/j.cjoms.2018.04.005 Abstract ( 617 )   PURPOSE:To evaluate the osteogenesis effect of maxillary sinus floor lift in Beagle dogs with bone grafting and without bone grafting. METHODS: Twelve operations (bilateral and randomly chosen) were done in 6 Beagle dogs in group A and group B (implanted Bio-Oss 0.8 mL), in which the operation was performed using maxillary sinus floor lift and immediate implant(3.5 mm×8 mm) placement. Postoperative CT scans, Micro-CT and histological analysis for all animals were conducted to evaluate the osteogenesis in the maxillary sinus floor and around the implants. SAS 9.0 software package was used for statistical analysis. RESULTS: The animals' incision healed well and without any complication such as infection. The osteogenic volume and bone density in group A was significantly lower than in group B on postoperative CT and 3 months after surgery's data. Micro-CT and histological analysis demonstrated that the osteogenesis in group A only surrounded the lower part of the implants, but surrounded all of the implants in group B. There was significant difference in new bone volume of the top and middle part of the implants between group A and B, but there was no significant difference in the lower part of the implants. CONCLUSIONS: There is certain amount of new bone formation at the lower part of the implants after maxillary sinus floor lift without bone implanting. To achieve better postoperative and long-term results, it is recommended to implant appropriate bone materials during maxillary sinus floor lift. References | Related Articles | Metrics

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TP53 truncating mutation as a predictive biomarker for induction chemotherapy in patients with locally advanced oral squamous cell carcinoma FU Yong, MA Jie, LIU Ying, TAN Yi-ran, JU Wu-tong, SUN Wen-wen, ZHAO Tong-chao, WANG Min, WANG Li-zhen, LI Jiang, ZHANG Chen-ping, ZHANG Zhi-yuan, ZHONG Lai-ping 2018, 16 (4):  322-327.  doi: 10.19438/j.cjoms.2018.04.006 Abstract ( 487 )   PURPOSE:To test the status of TP53 mutations in patients with locally advanced oral squamous cell carcinoma (OSCC) and investigate whether or not TP53 truncating mutation could be used as a predictive biomarker to screen patients who would benefit from induction chemotherapy. METHODS: One hundred and one patients with locally advanced OSCC treated in our hospital from 2008 to 2014 were included in this study. Their clinicopathologic information, frozen or formalin-fixed, paraffin-embedded samples of tumor and matched normal samples were collected. Using Ion PGM system, all samples were sequenced with high-throughput technology. Bioinformatics software was used to analyze and interpret the variants. SPSS 23.0 software package was used for statistical analysis. RESULTS: Among 101 patients, there were 74 men and 27 women with a median age of 59 years. The median follow-up time was 34.9 months. There were 102 TP53 non-synonymous mutations (allele frequency ≥3%) in 73 OSCC patients, with an average sequencing depth of 2366-fold in the tumor samples and 2225-fold in the matched normal samples. Compared with 42 patients who did not receive induction chemotherapy, 59 patients who received induction chemotherapy had a seemingly better distant metastasis free survival (P=0.090) while no significant difference in overall survival. Subgroup analysis showed that patients with TP53 truncating mutations could benefit from induction chemotherapy in distant metastasis free survival (P=0.038). CONCLUSIONS: Our study does not find that the patients with locally advanced OSCC could benefit from induction chemotherapy in overall survival, but TP53 truncating mutation could be used as a candidate of predictive biomarker to screen patients who would benefit from induction chemotherapy in distant metastasis free survival. References | Related Articles | Metrics

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Selection of way of internal fixation and biomechanical analysis for edentulous mandibular fractures with different atrophy degrees in elderly population LI Ming-zhe, XU Xiao-feng, XU Bing 2018, 16 (4):  328-333.  doi: 10.19438/j.cjoms.2018.04.007 Abstract ( 280 )   PURPOSE:To compare the result of different treatment methods (way of internal fixation) for edentulous mandibular fractures with 3 different atrophy degrees. METHODS: We established a biomechanical model of atrophic edentulous mandibular fracture and analyzed the displacement of the fracture and the stress on titanium plate with different treatment via finite element analysis. RESULTS: For atrophic mandibular fracture of class III, the displacement of using 1 miniplate in superior border of mandible was larger than other 6 conditions; For the same degree of atrophic mandibular fracture, the displacement of using reconstruction plate was smaller than other kinds of internal fixation; For atrophic mandibular fracture of class III, the stress on the titanium plate was near or above the yield limit for using 1 miniplate. CONCLUSIONS: For atrophic mandibular fracture of class I, both 2 miniplates and 1 reconstruction plate can achieve satisfactory results. For atrophic mandibular fracture of class II and III, 1 reconstruction plate can achieve more satisfactory results. References | Related Articles | Metrics

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Effect of immediate implantation combined with tissue cleaning on the morphology of soft tissue around the implant in dogs OUYANG Qian, HUANG Yan-fei, YANG Xiang-hong, LI De-hong, ZHOU Jing 2018, 16 (4):  334-337.  doi: 10.19438/j.cjoms.2018.04.008 Abstract ( 303 )   PURPOSE:To study the effect of immediate implantation combined with tissue cleaning on the morphology of soft tissue around the implant in dogs. METHODS: Totally 21 adult healthy hybrid dogs were selected for the experiment, which were divided into 3 groups based on different modes of operation: slipping mucoperiosteum flaps, free gingival flaps and allogeneic dermal matrix. Porcelain crown restoration was applied 3 months later. After 1-month of observation, all dogs were sacrificed in order to evaluate the morphological changes of the soft tissue around the implants. SPSS20.0 software package was used to analyze the data obtained. RESULTS: The healing of soft tissue around the implants in 3 groups were all good. Compared with the other two groups, the repairing outcome of the slipping mucoperiosteum flaps was worse. Free gingival flaps and allogeneic dermal matrix had the advantages on less negative effect of recovery and the morphology of soft tissue around the implant. The depth of sulcus in 3 groups had no significant difference. Nevertheless, the gingival index in the slipping mucoperiosteum flaps increased significantly after operation（P<0.05）. CONCLUSIONS: Immediate implantation combined with tissue cleaning has a positive effect on the morphology of soft tissue around the implant. References | Related Articles | Metrics

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The influence of functional splint therapy on post-surgical stability in patients with idiopathic condylar resorption: a pilot study HA Na-young, HONG Yue-yang, Yang Xiao, FANG Bing, JIANG Ling-yong 2018, 16 (4):  338-342.  doi: 10.19438/j.cjoms.2018.04.009 Abstract ( 409 )   PURPOSE:To investigate the influence of functional splint therapy, a conservative treatment which stabilizes the relationship between the condylar head and glenoid fossa, on post-surgical relapse in patients with idiopathic condylar resorption (ICR). METHODS: Thirteen patients treated between 2008—2012, who underwent orthognathic surgery for mandibular advancement were included in this retrospective study. Patients were treated with conventional functional splint therapy for 7.5±1.5 months followed by orthognathic surgery. Cephalometric analysis and temporomandibular joint spaces on serial magnetic resonance images were measured prior to orthognathic surgery(T0), immediately post-surgery(T1), and at least 12 months follow-up(T2) for evaluation of the long-term stability. The differences of data between the two periods were compared using SPSS 22.0 software package. RESULTS: All patients obtained an aesthetic facial profile after orthognathic surgery and a normal occlusion after treatment. Normal protrusive and lateral excursion were presented. The mean advancement of the mandible immediately following surgery (Y axis-B, T1-T0) was (5.05±3.54)mm. No significant difference in temporomandibular joint space was found between T1 and T2(0.17±1.93). Y Axis - B was the only measurement changed, which showed sagittal positional change of the mandible, the mean backward movement of (T2-T1) was (-1.64±2.48)mm. Eleven out of 13 patients presented no post-surgical relapse or less than 2 mm of mandibular backward movement(84.6%), 2 out of 13 patients showed more than 2 mm of mandibular backward movement(15.4%). CONCLUSIONS: Patients who underwent functional splint therapy showed stable condylar position in condylar fossa. Functional splint therapy reduces post-surgical relapse in patients with ICR. Functional splint therapy may be of value in patients with ICR treated with orthognathic surgery combined orthodontics. References | Related Articles | Metrics

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Relationship between expression of hypoxia-inducible factor 1α and clinical characteristic of recurrent ameloblastoma TANG Yu, CAO Wei, PENG Can-bang, LIU Zhe-qi, LIN Cheng-zhong, JI Tong 2018, 16 (4):  343-347.  doi: 10.19438/j.cjoms.2018.04.010 Abstract ( 299 )   PURPOSE:To detect the expression of hypoxia-inducible factor 1α in ameloblastoma and to determine if it was involved in the recurrence of ameloblastoma. METHODS: Five pairs of ameloblastoma and normal para-tissue were used for transcriptional group sequence; 120 formalin-fixed, paraffin-embeded tissue blocks of ameloblastoma specimens were compared at protein level using immunohistochemistry for HIF-1α staining. The data were analyzed with SAS 9.3 software package. RESULTS: The transcriptional level of HIF-1α and its related molecules in 3/5 specimens were changing consistently and obviously after sequencing; the HIF-1α and slug expression levels were significantly higher in recurrent ameloblastoma. About 40% of recurrent ameloblastoma had higher HIF-1α staining than primary ameloblastoma and 48.33% of recurrent ameloblastoma had higher slug staining than primary ameloblastoma (P<0.05). CONCLUSIONS: Higher expression of HIF-1α plays an important role in the recurrence of ameloblastoma. References | Related Articles | Metrics

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A retrospective study of 1264 cases of maxillofacial fractures ZHOU Yun-feng, LIU Qi, LI Zhi, LI Zu-bing 2018, 16 (4):  348-351.  doi: 10.19438/j.cjoms.2018.04.011 Abstract ( 346 )   PURPOSE:To analyze the epidemiological characteristics and treatment of maxillofacial fractures. METHODS: A retrospective clinical study was performed to assess 1264 patients' data, including age, gender, cause of fracture, site of fracture, associated systemic injuries and complications. RESULTS: There were 942(74.53%) males and 322(25.47%) females. The majority of fractures were found between 20 and 50 years old (59.10%). Nine hundred and sixty-five(76.35%) had accidental fall injuries, 276(21.84%) had systemic injuries, 120(37.62%) had brain and skull injuries. 1107(87.58%) were treated with rigid internal fixation. CONCLUSIONS: Males constitute the majority of maxillofacial fractures. The main cause of maxillofacial fractures is accidental fall injury, brain and skull injury are the most common complication. References | Related Articles | Metrics

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Application of vacuum sealing drainage assisted washing technology in 38 patients with severe multiple space infections in oral maxillofacial and neck region JIANG Jian-ping, GAO Bing-ju, QIU Yu, LI Jun, LIAO Yun-yang, YE Zhuo, LIN Yang, LIN Li-song 2018, 16 (4):  352-356.  doi: 10.19438/j.cjoms.2018.04.012 Abstract ( 295 )   PURPOSE:To evaluate the clinical efficacy of vacuum sealing drainage assisted washing technology and traditional incision and drainage in the treatment of severe multiple infection in oral maxillofacial and neck region. METHODS: The date of 73 patients from June 2014 to May 2017 in our hospital, who had severe multiple space infections in oral maxillofacial and neck region were analyzed retrospectively. Among 73 patients, 38 were treated with vacuum sealing drainage assisted washing technology, while 35 were treated with traditional incision drainage. Healing time, surgical scar length, work intensity (the time of dressing change), the costs of treatment of 2 groups were compared with SPSS 22.0 software package. RESULTS: All patients were cured. Compared with traditional incision drainage, the healing time, surgical scar length and work intensity in cases with vacuum sealing drainage assisted washing were shorter or lesser, the difference was statistically significant (P<0.05), but there was no significant difference in the cost of treatment between the two groups(P>0.05). CONCLUSIONS: Compared with traditional incision drainage group, vacuum sealing drainage assisted washing technology for severe multiple space infection in oral maxillofacial and neck region can achieve better clinical outcome, which makes faster healing, shorter scar, higher effectiveness, and thus is worthy of wide application. References | Related Articles | Metrics

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Radiographic evaluation of the correlation between the status of mandibular third molars and the lesion of the mandibular second molars LI Chen-lin, XU Guang-zhou, YANG Chi, WANG Yong 2018, 16 (4):  357-361.  doi: 10.19438/j.cjoms.2018.041.013 Abstract ( 463 )   PURPOSE:To evaluate the correlation between the eruption status of the mandibular third molars (M3Ms) and distal caries, periodontal defects, external root resorption in the mandibular second molars (M2Ms) and provide references for early removal of the high risk M3Ms to prevent damage of M2Ms. METHODS: 3000 patients (4028 mandibular third molars) were involved in this study. Panoramic radiography images were used to analyze the location of the mandibular third molars (Winter's classification) and distal caries, periodontal defects, external root resorption in the mandibular second molars. Chi-square test (R programming language, Version 3.4.5) was used to analyze the relation between pathology of M2Ms and classification of M3Ms. RESULTS: Different Winter's classification of mandibular third molars were related to the lesion of the mandibular second molars (P<0.001). Distal caries in the mandibular second molars were most prevalent when the mandibular third molars were mesioangular (P<0.001). Periodontal defects in the mandibular second molars were most prevalent when the mandibular third molars were vertical or distoangular (P<0.001). External root resorption in the mandibular second molars were most prevalent when the mandibular third molars were inverted (P<0.001). CONCLUSIONS: Distal caries, periodontal defects, external root resorption in the mandibular second molars were closely related to the classification of mandibular third molars. Impacted mandibular third molars should be extracted as early as possible. References | Related Articles | Metrics

Expert Consensus

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Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma TANG Zhan-gui, BU Rong-fa, LIU Yan-pu, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, HE Yue, SHANG Zheng-jun, WU Yu-nong, LI Jin-song, HAN Zheng-xue, TIAN Zhen, ZHANG Chen-ping, LI Tie-jun, ZHONG Ming, LIAO Gui-qing, SHEN Zi-hua, HUANG Jun-hui, YU Jian-jun, SU Tong, YAO Zhi-gang, HU Yan-jia 2018, 16 (4):  362-370.  doi: 10.19438/j.cjoms.2018.04.014 Abstract ( 729 )   Oral verrucous carcinoma (OVC) is a malignant tumor with independent histological changes and biological behaviors different from those of oral squamous cell carcinomas (OSCC). Its etiology is still unclear. It has the first clinical diagnosis coincidence rate of only 35% and is often misdiagnosed as other oral diseases such as verrucous hyperplasia, odontogenic keratocyst, aggressive periodontitis and chronic osteomyelitis. The treatment and prognosis of OVC are different from those of OSCC. Its misdiagnosis and mistreatment seriously affect patients' quality of life. In order to reduce misdiagnosis and mistreatment of OVC and to improve its early diagnostic rate, patients' survival rate and quality of life, it is necessary to establish an expert consensus on this tumor according to the national clinical conditions. References | Related Articles | Metrics

Dental Education

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Application of clinical case database based on 3D-printing in clinical teaching of oral maxillofacial bone diseases HUANG Li1, LI Lu2, JIANG Can-yang1, HUANG Jian-ping1, JIANG Yan1, LIAO Yun-yang1, LIN Li-song1 HUANG Li, LI Lu, JIANG Can-yang, HUANG Jian-ping, JIANG Yan, LIAO Yun-yang, LIN Li-song 2018, 16 (4):  371-375.  doi: 10.19438/j.cjoms.2018.04.015 Abstract ( 292 )   PURPOSE:To explore the value of clinical case database based on 3D-printing in clinical teaching of oral maxillofacial bone diseases. METHODS: 3D printing models and clinical data of 80 cases with typical oral and maxillofacial bone diseases were selected to establish teaching database of typical clinical cases. Thirty-four undergraduates (grade 2013) majoring in stomatology from Fujian Medical University were randomly divided into experimental group and control group, with 17 students in each group. Students in the control class were received traditional teaching methods, whereas the new teaching model of combination with typical clinical case teaching database based on 3D printing and clinical data was employed in the experimental group. All students were examined in theory and skill with the same examination standard (a hundred marks), and the learning effect was evaluated by questionnaire after the courses ended. The data were compared with independent-samples t test using SPSS 19.0 software package. RESULTS: The overall clinical assessment score of the experimental group was(78.82±; 3.70), while the score of the control group was(72.94±; 3.70). In the experimental group, the score result of questionnaire was(22.88±; 0.70), while the score of the control group was(17.29±; 1.53), the differences were statistically significant(P<; 0.05). CONCLUSIONS: Use of teaching database of typical clinical cases based on 3D-printing in the clinical teaching of oral maxillofacial bone diseases can significantly help students to firmly grasp the teaching contents, form their clinical ideation, foster their practical capability and stimulate their learning enthusiasm and confidence, which is worth wide application. References | Related Articles | Metrics

Review Articles

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Histopathological and molecular markers in prognostic evaluation of salivary mucoepidermoid carcinoma WANG Yang, TIAN Zhen 2018, 16 (4):  376-381.  doi: 10.19438/j.cjoms.2018.04.016 Abstract ( 617 )   Mucoepidermoid carcinoma (MEC） is the most common salivary gland malignancies, which used to be classified as mucoepidermoid tumor. Although MEC is composed basically of 3 different cell types: a mucin-producing cell, an epidermoid cell, and an intermediate cell, MEC may have different biological behaviors, which can be divided into low, moderate, and high grade. It is important to distinguish the histopathologic grade, in order to make appropriate treatment plan. In recent years, several prognostic molecular markers have been discovered, which are expected to be combined with the traditional histopathological classification to form a rating system for improving prognosis assessment of MEC. References | Related Articles | Metrics

Case Report

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Burkitt lymphoma of the jaw and maxillary sinus: case report and literature review WANG Pan-pan, WANG Yu-fan, YANG Hong-yu 2018, 16 (4):  382-384.  doi: 10.19438/j.cjoms.2018.04.017 Abstract ( 490 )   Burkitt lymphoma,also known as African lymphoma, is more common in African children. This paper reported a case of Burkitt lymphoma occurring in bilateral mandible, the left maxilla and the left maxillary sinus. The pathogenesis, clinical characteristics, diagnosis, differential diagnosis, treatment and prognosis were discussed. References | Related Articles | Metrics