Meta-analysis on risk factors for postoperative pulmonary infection in patients with oral cancers

doi:10.19438/j.cjoms.2023.05.015

Abstract

Abstract: PURPOSE: To systematically review the influencing factors of postoperative pulmonary infection in patients with oral cancers. METHODS: The database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, Wanfang, VIP, China Biomedical Literature Database were searched through computer for studies on the influencing factors of postoperative pulmonary infection in oral cancer patients, including case-control studies and cohort research, the search time limit was from the establishment of the database to November 1, 2022. RESULTS: Finally, 11 articles were included, with a total of 3 458 patients. Meta-analysis results showed that smoking history[OR=5.88, 95%CI(1.49,23.26), P=0.011], diabetes history[OR=2.64, 95%CI(1.20,17.54), P=0.023], previous radiotherapy history[OR=8.21, 95%CI(1.45,46.468), P=0.017], poor preoperative oral hygiene [OR=10.17, 95%CI(2.14,48.32), P=0.004], operation time[OR=1.34, 95%CI(1.12,1.61), P=0.001], anesthesia time[OR=2.04, 95%CI(1.262,3.298), P=0.004], flap size [OR=1.02, 95%CI(1.008,1.034), P=0.001],flap type[OR=17.71, 95%CI(4.15,75.56), P=0.0001], delayed activity (>4 days)[OR=4.20, 95%CI(1.057,17.074), P=0.04], and postoperative hospital stay[OR=1.14, 95%CI(1.05,1.24), P=0.002] were independent risk factors for postoperative pulmonary infection in patients with oral cancer; age tracheotomy, intraoperative blood loss, mandibular resection, tracheal tube indwelling time, and flap repair were influencing factors for postoperative pulmonary infection in patients with oral cancers. Preoperative serum albumin level[OR=0.79, 95%CI(0.67,0.94), P=0.005] was protective factor for postoperative pulmonary infection in patients with oral cancers. CONCLUSIONS: There are many factors that affect postoperative pulmonary infection in patients with oral cancers. Targeted and individualized intervention should be carried out to prevent the occurrence of pulmonary infection, which is of great significance to promote postoperative rehabilitation of patients with oral cancers.

Key words: Oral cancer, Lung infection, Tract infection, Risk factors, Meta-analysis

CLC Number:

R739.8

CHEN Yu, TAO Ming, LEI Yin-fu, WU He-mei, PENG Xiao-feng, GOU Deng-qun. Meta-analysis on risk factors for postoperative pulmonary infection in patients with oral cancers[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(5): 511-517.

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