Relationship between expression of hypoxia-inducible factor 1α and clinical characteristic of recurrent ameloblastoma

doi:10.19438/j.cjoms.2018.04.010

China Journal of Oral and Maxillofacial Surgery ›› 2018, Vol. 16 ›› Issue (4): 343-347.doi: 10.19438/j.cjoms.2018.04.010

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Relationship between expression of hypoxia-inducible factor 1α and clinical characteristic of recurrent ameloblastoma

TANG Yu, CAO Wei, PENG Can-bang, LIU Zhe-qi, LIN Cheng-zhong, JI Tong

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2018-03-01 Revised:2018-04-07 Online:2018-07-20 Published:2018-08-09

Abstract

Abstract: PURPOSE:To detect the expression of hypoxia-inducible factor 1α in ameloblastoma and to determine if it was involved in the recurrence of ameloblastoma. METHODS: Five pairs of ameloblastoma and normal para-tissue were used for transcriptional group sequence; 120 formalin-fixed, paraffin-embeded tissue blocks of ameloblastoma specimens were compared at protein level using immunohistochemistry for HIF-1α staining. The data were analyzed with SAS 9.3 software package. RESULTS: The transcriptional level of HIF-1α and its related molecules in 3/5 specimens were changing consistently and obviously after sequencing; the HIF-1α and slug expression levels were significantly higher in recurrent ameloblastoma. About 40% of recurrent ameloblastoma had higher HIF-1α staining than primary ameloblastoma and 48.33% of recurrent ameloblastoma had higher slug staining than primary ameloblastoma (P<0.05). CONCLUSIONS: Higher expression of HIF-1α plays an important role in the recurrence of ameloblastoma.

Key words: HIF-1α, Ameloblastoma, Slug

CLC Number:

R739.8

TANG Yu, CAO Wei, PENG Can-bang, LIU Zhe-qi, LIN Cheng-zhong, JI Tong. Relationship between expression of hypoxia-inducible factor 1α and clinical characteristic of recurrent ameloblastoma[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(4): 343-347.

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Relationship between expression of hypoxia-inducible factor 1α and clinical characteristic of recurrent ameloblastoma

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