Association of ABO blood groups with cleft palate in 274 patients in the northeast China

doi:10.19438/j.cjoms.2018.02.010

Abstract

Abstract: PURPOSE: To evaluate the relation between blood grouping and the presence of cleft palate. METHODS: From October 2012 to January 2017,the clinical records of 274 patients (age range 0-61 years) with congenital cleft palate who were treated at the Stomatological Hospital of China Medical University were selected as case group. There were 113 males and 161 females(male:female=1:1.42); the control group was consisted of 978 patients without cleft lip and/or palate who visited the hospital due to other problems. Statistical analysis was performed on the blood group distribution of patients with cleft palate and the control group using SPSS 22.0 software package. RESULTS: Blood type frequency of patients with cleft palate and controls was B>O>A>AB. Chi-square test showed that association of blood groups with cleft palate was not statistically significant(P>0.05).Congenital incomplete cleft palate and unilateral complete cleft palate(75.55%) were the most common types, followed by submucosal cleft palate(22.26%) and bilateral complete cleft palate(2.19%) was the least one. Women with cleft palate (58.76%) were more than men (41.24%) and the rural patients(54.74%) were more than the urban ones(45.26%). CONCLUSIONS: Congenital incomplete cleft palate and unilateral complete cleft palate are the most common types, followed by submucosal cleft palate and bilateral complete cleft palate is the least one. The occurrence of cleft palate is unrelated to ABO blood groups, it is possibly related to gender and urban and rural areas.

Key words: Cleft palate, ABO blood groups, Genetic analysis

CLC Number:

R783.5

SHI Chun-ling, LI Duo, LIU Yi. Association of ABO blood groups with cleft palate in 274 patients in the northeast China[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(2): 149-152.

References

[1] Dixon MJ, Marazita ML, Beaty TH, et al.Cleft lip and palate: synthesizing genetic and environmental influences[J]. Nat Rev Genet, 2011, 12(3): 167-178.
[2] Burg ML, Chai Y, Yao CA, et al.Epidemiology, etiology, and treatment of isolated cleft palate[J]. Front Physiol, 2016, 7: 67.
[3] Prescott NJ, Winter RM, Malcolm S.Nonsyndromic cleft lip and palate: complex genetics and environmental effects[J]. Ann Hum Genet, 2001, 65(6): 505-515.
[4] Molina-Solana R, Yáñez-Vico RM, Iglesias-Linares A, et al.Current concepts on the effect of environmental factors on cleft lip and palate[J]. Int J Oral Maxillofac Surg, 2013, 42(2):177-184.
[5] Cooling L.Blood groups in infection and host susceptibility[J]. Clin Microbiol Rev, 2015, 28(3): 801-870.
[6] Chen Q, Zheng Q, Shi B, et al.Study of relationship between clinical factors and velopharyngeal closure in cleft palate patients[J]. J Res Med Sci, 2011, 16(7): 945-950.
[7] 彭德仁. 中国汉族人ABO血型的分布[J]. 中国输血杂志, 1991, 4(1): 20-23.
[8] 张艳萍, 李逸松, 梁娜, 等. 1253例唇腭裂患者的临床资料分析[J]. 现代口腔医学杂志, 2005, 19(6): 642-643.
[9] Calzolari E, Bianchi F, Rubini M, et al.Epidemiology of cleft palate in Europe: implications for genetic research[J]. Cleft Palate Craniofac J, 2004, 41(3):244-249.
[10] Bicknell S, Mcfadden LR, Curran JB.Frequency of pharyngoplasty after primary repair of cleft palate[J]. J Can Dent Assoc, 2002, 68(11): 688-692.
[11] 吴楠, 秦晓飞. 唇腭裂的序列治疗及相关问题探讨[J]. 中国实用口腔科杂志, 2008, 1(12): 761-762.
[12] Tomasz R, Kosowski, William M, et al.Cleft palate[J]. Semin Plast Surg, 2012, 26(4): 164-169.
[13] Rummel SK, Ellsworth RE. The role of the histoblood ABO group in cancer [J]. Future Sci OA, 2016, 2(2): FSO107.
[14] Zhang H, Mooney CJ, Reilly MP.ABO blood groups and cardiovascular diseases[J]. Int J Vasc Med, 2012, 2012: 641917.
[15] Mortazavi H, Hajian S, Fadavi E, et al.ABO blood groups in oral cancer: first case-control study in a defined group of Iranian patients[J]. Asian Pac J Cancer Prev, 2014, 15(3): 1415-1418.
[16] Sharma R, Preethi PN, Nagarathna C, et al.Association of ABO blood groups with malocclusion in population of jaipur, India: a prospective study[J].Int J Sci Stud, 2015, 2(11): 45-51.
[17] Koregol A, Raghavendra M, Nainegali S, et al.ABO blood groups and Rhesus factor: An exploring link to periodontal diseases[J].Indian J Dent Res, 2010, 21(3): 364-368.
[18] Demir T, Tezel A, Orbak R, et al.The effect of ABO blood types on periodontal status[J]. Eur J Dent, 2007, 1(3): 139-143.
[19] Ghaib NH, Alhuwaizi AF.Cleft lip and/or cleft palate in relation to blood grouping[J]. Iraqi Dent J, 2002, 30(1): 67-76.
[20] Al-Janabi MF.Distribution of ABO blood group and Rh factor in relation to different types of cleft lip and/or palate[J]. J Bagh Coll Dentistry, 2017, 19(1): 112-114.
[21] Cerny M, Fára M, Hrivnáková J.Contrary characteristics of A and B blood groups in cleft lip and palate[J]. Acta Chir Plast, 1988, 30(4): 222-233.
[22] 李小丹, 邓末宏, 傅豫川. 湖北地区唇腭裂患者的ABO血型研究[J]. 口腔医学研究, 2004, 20(4): 430-431.
[23] Letra A, Menezes R, Govil M, et al.Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate[J]. Am J Med Genet A, 2010, 152A(7): 1701-1710.
[24] Bachtrog D, Mank JE, Peichel CL, et al.Sex determination: why so many ways of doing it?[J]. PLoS Biol, 2014, 12(7): e1001899.
[25] 彭莉, 牛振民, 陈振琦. 非综合征型唇腭裂候选基因研究进展[J]. 中国口腔颌面外科杂志, 2015, 13(4): 377-381.