Correlation of serum biochemical factors and vascular crisis of free flap for reconstruction of oral and maxillofacial defect

doi:10.19438/j.cjoms.2017.05.011

Abstract

Abstract: PURPOSE: To investigate the effects of serum biochemical factors on the vascular crisis of free flaps for reconstruction of oral and maxillofacial defects. METHODS: The medical records of patients who underwent free flap transplantation for oral and maxillofacial reconstruction between January 2002 and April 2014 at the Stomatological Hospital Affiliated to Guangxi Medical University were reviewed. Of the 799 patients who had free flap reconstruction, 64 free flaps had crisis, 43 were salvaged successfully and 21 were lost.　Ｓｉｘｔｙ－ｓｉｘ patients from 735 patients without crisis of free flap were selected as control group. Preoperative routine serum biochemical parameters including albumin, globin, prealbumin, fibrinogen and PT etc, were collected and analyzed with SPSS 16.0 software package. RESULTS: The results of student's t test showed that albumin in the vascular crisis group was significantly lower than that in the control group after receiving free flap transplantation.　However, fibrinogen in vascular crisis group was significantly higher than that in control group(P<0.05).　Logistic regression analysis showed that fibrinogen was a risk factor for flap vascular crisis (P<0.05). CONCLUSIONS: Increased fibrinogen in pre operative serum may raise the risk of vascular crisis of free flap for oral and maxillofacial reconstruction.

Key words: Free flap, Vascular crisis, Serum biochemical factors

CLC Number:

Ｒ782.2

YANG Liang-hui, MAI Hua-ming, WU Jia-xiao, LI Shuai, CHEN Guo-sheng, LIU Shi-qi.. Correlation of serum biochemical factors and vascular crisis of free flap for reconstruction of oral and maxillofacial defect[J]. China Journal of Oral and Maxillofacial Surgery, 2017, 15(5): 431-434.

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